Mechanosensory neurons, cutaneous mechanoreceptors, and putative mechanoproteins

Microscopy Research and Technique

Volumn 75, Issue 8, 2012, Pages 1033-1043

  Del Valle, M E ^a   Cobo, T ^a   Cobo, J L ^a   Vega, J A ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Acid sensing ion channels; Cutaneous mechanoreceptors; Mechanoproteins; Mechanosensory neurons; Touch; Transient receptor potential channels

Indexed keywords

IONS; MAMMALS; TRANSIENTS;

ACID-SENSING ION CHANNELS; CUTANEOUS MECHANORECEPTOR; ION CHANNEL; MECHANICAL STIMULUS; MECHANOPROTEIN; MECHANORECEPTORS; MECHANOSENSITIVITY; MECHANOSENSORY NEURON; TOUCH; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

NEURONS;

MAMMALIA; MUS;

EID: 84864305281     PISSN: 1059910X     EISSN: 10970029     Source Type: Journal    
DOI: 10.1002/jemt.22028     Document Type: Article

References (144)

1. Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M. 1996. Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following pferipheral target innervation. Neuron 16: 287-295.
2. Alenghat FJ, Ingber DE. 2002. Mechanotransduction: All signals point to cytoskeleton, matrix, and integrins. Sci STKE pe6. Doi: 10.1126/stke. 2002.119.pe6.
3. Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine JD. 2005. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 118: 70-79.
4. Alloui A, Zimmermann K, Mamet J, Duprat F, Noël J, Chemin J, Guy N, Blondeau N, Voilley N, Rubat-Coudert C, Borsotto M, Romey G, Heurteaux C, Reeh P, Eschalier A, Lazdunski M. 2006. TREK-1, a K+ channel involved in polymodal pain perception. EMBO J 25: 2368-2376.
5. Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM. 2002. Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. Proc Natl Acad Sci USA 99: 2326-2331.
6. Arnadóttir J, Chalfie M. 2010. Eukaryotic mechanosensitive channels. Annu Rev Biophys 39: 111-137.
7. Bassler EL, Ngo-Anh TJ, Geisler HS, Ruppersberg JP, Gründer S. 2001. Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b. J Biol Chem 276: 33782-33787.
8. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. 2006. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124: 1269-1282.
9. Belmonte C, Viana F. 2008. Molecular and cellular limits to somatosensory specificity. Mol Pain 4: 14. Doi: 10.1186/1744-8069-4-14.
10. Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, Puech S, Boukhaddaoui H, Baudet C, Takahashi S, Valmier J, Carroll P. 2009. Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron 64: 857-870.
11. Brown AL, Liao Z, Goodman MB. 2008. MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: Auxiliary subunits that enable channel activity. J Gen Physiol 131: 605-616.
12. Calavia MG, Montaño JA, García-Suárez O, Feito J, Guervós MA, Germanà A, Del Valle M, Pérez-Piñera P, Cobo J, Vega JA. 2010. Differential localization of Acid-sensing ion channels 1 and 2 in human cutaneus pacinian corpuscles. Cell Mol Neurobiol 30: 841-848.
13. Caterina MJ, Julius D. 2001. The vanilloid receptor: A molecular gateway to the pain pathway. Annu Rev Neurosci 24: 487-517.
14. Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ. 2009. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci USA 106: 9075-9080.
15. Chalfie M. 2009. Neurosensory mechanotransduction. Nat Rev Mol Cell Biol 10: 44-52.
16. Chemin J, Patel AJ, Duprat F, Lauritzen I, Lazdunski M, Honoré E. 2005. A phospholipid sensor controls mechanogating of the K+ channel TREK-1. EMBO J 24: 44-53.
17. Chemin J, Nargeot J, Lory P. 2007. Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels. J Biol Chem 282: 2314-2323.
18. -/- mice. Mol Pain 3: 31. doi: 10.1186/1744-8069-3-31.
19. Chen CS. 2008. Mechanotransduction-A field pulling together? JCell Sci 121(Pt 20): 3285-3292.
20. Christensen AP, Corey DP. 2007. TRP channels in mechanosensation: Direct or indirect activation? Nat Rev Neurosci 8: 510-521.
21. Clapham DE, Julius D, Montell C, Schultz G. 2005. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev 57: 427-450.
22. Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A. 2010. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330: 55-60.
23. de Carlos F, Cobo J, Germanà G, Silos-Santiago I, Laurà R, Haro JJ, Fariñas I, Vega JA. 2006. Abnormal development of Pacinian corpuscles in double trkB;trkC knockout mice. Neurosci Lett 410: 157-161.
24. Delmas P, Hao J, Rodat-Despoix L. 2011. Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci 12: 139-153.
25. + channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. J Physiol 585: 867-879.
26. Drew LJ, Wood JN, Cesare P. 2002. Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. J Neurosci 22: RC228.
27. Drew LJ, Rohrer DK, Price MP, Blaver KE, Cockayne DA, Cesare P, Wood JN. 2004. Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol (Lond) 556: 691-710.
28. Drummond HA, Abboud FM, Welsh MJ. 2000. Localization of β and γ subunits of ENaC in sensory nerve endings in the rat foot pad. Brain Res 884: 1-12.
29. Dubový P, Bednárová J. 1999. The extracellular matrix of rat pacinian corpuscles: An analysis of its fine structure. Anat Embryol 200: 615-623.
30. Dubový P, Svízenská I, Jancálek R, Klusáková I. 1999. Immunohistochemical localization of some extracellular molecules and their integrin receptors in the rat Pacinian corpuscles. Gen Physiol Biophys 18( Suppl 1): 66-68.
31. DuFort CC, Paszek MJ, Weaver VM. 2011. Balancing forces: Architectural control of mechanotransduction. Nat Rev Mol Cell Biol 12: 308-319.
32. Duggan A, Garcia-Anoveros J, Corey DP. 2002. The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J Biol Chem 277: 5203-5208.
33. Duprat F, Lauritzen I, Patel A, Honoré E. 2007. The TASK background K2P channels: Chemo- and nutrient sensors. Trends Neurosci 30: 573-580.
34. Eid SR, Cortright DN. 2009. Transient receptor potential channels on sensory nerves. Handbook Exp Pharmacol 194: 261-281.
35. Garcia-Añoveros J, Samad TA, Zuvela-Jelaska L, Woolf CJ, Corey DP. 2001. Transport and localization of the DEG/ENaC ion channel BNaC1α to peripheral mechanosensory terminals of dorsal root ganglia neurons. J Neurosci 21: 2678-2686.
36. Gillespie PG, Walker RG. 2001. Molecular basis of mechanosensory transduction. Nature 413: 194-202.
37. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S. 2005. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev 57: 527-540.
38. González-Martinez T, Germanà GP, Monjil DF, Silos-Santiago I, de Carlos F, Germanà G, Cobo J, Vega JA. 2004. Absence of Meissner corpuscles in the digital pads of mice lacking functional TrkB. Brain Res 1002: 120-128.
39. González-Martinez T, Fariñas I, del Valle ME, Feito J, Germanà G, Cobo J, Vega JA. 2005. BDNF, but not NT-4, is necessary for normal development of Meissner Pacinian corpuscles. Neurosci Lett 377: 12-15.
40. Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW. 2007. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol 578(Pt 3): 715-733.
41. Halata Z, Grim M, Bauman KI. 2003. Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: Review and new results. Anat Rec A Discov Mol Cell Evol Biol 271: 225-239.
42. Heurteaux C, Guy N, Laigle C, Blondeau N, Duprat F, Mazzuca M, Lang-Lazdunski L, Widmann C, Zanzouri M, Romey G, Lazdunski M. 2004. TREK-1, a K+ channel involved in neuroprotection and general anesthesia. EMBO J 23: 2684-2695.
43. Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thümmler S, Peng XD, Noble F, Blondeau N, Widmann C, Borsotto M, Gobbi G, Vaugeois JM, Debonnel G, Lazdunski M. 2006. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nature Neurosci 9: 1134-1141.
44. Hitomi Y, Suzuki A, Kawano Y, Nozawa-Inoue K, Inoue M, Maeda T. 2009. Immunohistochemical detections of ENaCβ in the terminal Schwann cells associated with periodontal Ruffini endings of the rat incisor. Biomed Res 30: 113-119.
45. Holzer P. 2009. Acid-sensitive ion channels and receptors. Handbook Exp Pharmacol 194: 283-332.
46. Holzer P. 2011. Acid sensing by visceral afferent neurones. Acta Physiol 201: 63-75.
47. Honma Y, Kawano M, Kohsaka S, Ogawa M. 2010. Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret. Development 137: 2319-2328.
48. Hu J, Lewin GR. 2006. Mechanosensitive currents in the neurites of cultured mouse sensory neurones. J Physiol 577(Pt 3): 815-828.
49. Hughes PA, Brierley SM, Young RL, Blackshaw LA. 2007. Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. J Comp Neurol 500: 863-875.
50. Ingber DE. 2006. Cellular mechanotransduction: Putting all the pieces together again. FASEB J 20: 811-827.
51. Johnson KO. 2002. The roles and functions of cutaneous mechanoreceptors. Curr Opin Neurobiol 11: 455-461.
52. Kang D, Kim D. 2006. TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons. Am J Physiol Cell Physiol 291: C138-C146.
53. Kang D, Choe C, Kim D. 2005. Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. J Physiol 564(Pt 1): 103-116.
54. Kawamata T, Ninomiya T, Toriyabe M, Yamamoto J, Niiyama Y, Omote K, Namiki A. 2006. Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy. Neuroscience 143: 175-187.
55. Krimm RF, Davis BM, Noel T, Albers KM. 2006. Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number. J Comp Neurol 498: 455-465.
56. Krishtal O. 2003. The ASICs: Signaling molecules? Modulators? Trends Neurosci 26: 477-483.
57. Kwan KY, Glazer JM, Corey DP, Rice FL, Stucky CL. 2009. TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci 29: 4808-4819.
58. Laitko U, Juranka PF, Morris CE. 2006. Membrane stretch slows the concerted step prior to opening in a Kv channel. J Gen Physiol 127: 687-701.
59. Lechner SG, Frenzel H, Wang R, Lewin GR. 2009. Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO J 28: 1479-1491.
60. Lecoin L, Rocques N, El-Yakoubi W, Ben Achour S, Larcher M, Pouponnot C, Eychène A. 2010. MafA transcription factor identifies the early ret-expressing sensory neurons. Dev Neurobiol 70: 485-497.
61. Lee H, Caterina MJ. 2005. TRPV channels as thermosensory receptors in epithelial cells. Pflugers Arch 451: 160-167.
62. LeMaster AM, Krimm RF, Davis BM, Noel T, Forbes ME, Johnson JE, Albers KM. 1999. Overexpression of brain-derived neurotrophic factor enhances sensory innervation and selectively increases neuron number. J Neurosci 19: 5919-5931.
63. Liedtke W. 2005. TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. J Physiol 567(Pt 1): 53-58.
64. Liedtke W, Friedman JM. 2003. Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci USA 100: 13698-13703.
65. Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S. 2000. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103: 525-535.
66. Liedtke W, Tobin DM, Bargmann CI, Friedman JM. 2003. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci USA 100( Suppl 2): 14531-14536.
67. Lin YW, Cheng CM, Leduc PR, Chen CC. 2009. Understanding sensory nerve mechanotransduction through localized elastomeric matrix control. PLoS One 4: e4293.
68. Lingueglia E. 2007. Acid-sensing ion channels in sensory perception. J Biol Chem 282: 17325-17329.
69. Lingueglia E, De Weille, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M. 1997. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem 272: 29778-29783.
70. Liu Y, Ma Q. 2011. Generation of somatic sensory neuron diversity and implications on sensory coding. Curr Opin Neurobiol 21: 52-60.
71. Lumpkin EA, Bautista DM. 2005. Feeling the pressure in mammalian somatosensation. Curr Opin Neurobiol 15: 382-388.
72. Lumpkin EA, Caterina MJ. 2007. Mechanisms of sensory transduction in the skin. Nature 445: 858-865.
73. Lumpkin EA, Marshall KL, Nelson AM. 2010. The cell biology of touch. J Cell Biol 191: 237-248.
74. Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD. 2007. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54: 739-754.
75. Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD. 2009. Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron 64: 841-856.
76. Maingret F, Fosset M, Lesage F, Lazdunski M, Honoré E. 1999a. TRAAK is a mammalian neuronal mechano-gated K+ channel. J Biol Chem 274: 1381-1387.
77. Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E. 1999b. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 274: 26691-26696.
78. Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honoré E. 2000a. TREK-1 is a heat-activated background K(+) channel. EMBO J 19: 2483-2491.
79. Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E. 2000b. Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. J Biol Chem 275: 10128-10133.
80. Mannsfeldt AG, Carroll P, Stucky CL, Lewin GR. 1999. Stomatin, a MEC-2 like protein, is expressed by mammalian sensory neurons. Mol Cell Neurosci 13: 391-404.
81. Maricich SM, Xia A, Mathes EL, Wang VY, Oghalai JS, Fritzsch B, Zoghbi HY. 2009. Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei. J Neurosci 29: 11123-11133.
82. Markin VS, Sachs F. 2004. Thermodynamics of mechanosensitivity. Phys Biol 1: 110-124.
83. Martinez-Salgado C, Benckendorff AG, Chiang LY, Wang R, Milenkovic N, Wetzel C, Hu J, Stucky CL, Parra MG, Mohandas N, Lewin GR. 2007. Stomatin and sensory neuron mechanotransduction. J Neurophysiol 98: 3802-3808.
84. Matthews BD, Overby DR, Mannix R, Ingber DE. 2006. Cellular adaptation to mechanical stress: Role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci 119: 508-518.
85. McCarter GC, Reichling DB, Levine JD. 1999. Mechanical transduction by rat dorsal root ganglion neurons in vitro. Neurosci Lett 273: 179-182.
86. McIlwrath SL, Hu J, Anirudhan G, Shin JB, Lewin GR. 2005. The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability. Neuroscience 131: 499-511.
87. McIlwrath SL, Lawson JJ, Anderson CE, Albers KM, Koerber HR. 2007. Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors. Eur J Neurosci 26: 1801-1812.
88. Medhurst AD, Rennie G, Chapman CG, Meadows H, Duckworth MD, Kelsell RE, Gloger II, Pangalos MN. 2001. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res 86: 101-114.
89. Mogil JS, Breese NM, Witty MF, Ritchie J, Rainville ML, Ase A, Abbadi N, Stucky CL, Séguéla P. 2005. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. J Neurosci 25: 9893-9901.
90. Montaño JA, Calavia MG, García-Suárez O, Suarez-Quintanilla JA, Gálvez A, Pérez-Piñera P, Cobo J, Vega JA. 2009. The expression of ENa (+) C and ASIC2 proteins in Pacinian corpuscles is differently regulated by TrkB and its ligands BDNF and NT-4. Neurosci Lett 463: 114-118.
91. Montaño JA, Pérez-Piñera P, García-Suárez O, Cobo J, Vega JA. 2010. Development and neuronal dependence of cutaneous sensory nerve formations: Lessons from neurotrophins. Microsc Res Tech 73: 513-529.
92. Morris CE, Juranka PF. 2007. Nav channel mechanosensitivity: Activation and inactivation accelerate reversibly with stretch. Biophys J 93: 822-833.
93. Morrison KM, Miesegaes GR, Lumpkin EA, Maricich SM. 2009. Mammalian Merkel cells are descended from the epidermal lineage. Dev Biol 336: 76-83.
94. Munger BL, Ide C. 1988. The structure and function of cutaneous sensory receptors. Arch Histol Cytol 51: 1-34.
95. Munger BL, Yoshida Y, Hayashi S, Osawa T, Ide C. 1988. A re-evaluation of the cytology of cat Pacinian corpuscles. I. The inner core and clefts. Cell Tissue Res 253: 83-93.
96. Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y. 2003. TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93: 829-838.
97. Nilius B, Owsianik, G. 2011. The transient receptor potential family of ion channels. Genome Biol 12: 218. Doi: 10.1186/gb-2011-12-3-218.
98. Noël J, Zimmermann K, Busserolles J, Deval E, Alloui A, Diochot S, Guy N, Borsotto M, Reeh P, Eschalier A, Lazdunski M. 2009. The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J 28: 1308-1318.
99. O'Hagan R, Chalfie M, Goodman MB. 2005. The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat Neurosci 8: 43-50.
100. Orr AW, Helmke BP, Blackman BR, Schwartz MA. 2006. Mechanisms of mechanotransduction. Dev Cell 10: 11-20.
101. Pack AK, Pawson LJ. 2010. Neuroglial modulation in peripheral sensory systems. Neuroscientist 16: 342-348.
102. Page AJ, Brierley SM, Martin CM, Martinez-Salgado C, Wemmie JA, Brennan TJ, Symonds E, Omari T, Lewin GR, Welsh MJ, Blackshaw LA. 2004. The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology 127: 1739-1747.
103. Page AJ, Brierley SM, Martin CM, Price MP, Symonds E, Butler R, Wemmie JA, Blackshaw LA. 2005. Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut 54: 1408-1415.
104. + channel. EMBO J 17: 4283-4290.
105. Patel AJ, Lazdunski M, Honoré E. 2001. Lipid and mechano-gated 2P domain K(+) channels. Curr Opin Cell Biol 13: 422-428.
106. Pawson L, Slepecky NB, Bolanowski SJ. 2000. Immunocytochemical identification of proteins within the Pacinian corpuscle. Somatosens Motil Res 17: 159-170.
107. Pawson L, Prestia LT, Mahoney GK, Güçlü B, Cox PJ, Pack AK. 2009. GABAergic/ glutamatergic-glial/neuronal interaction contributes to rapid adaptation in pacinian corpuscles. J Neurosci 29: 2695-2705.
108. Pérez-Piñera P, García-Suarez O, Germanà A, Díaz-Esnal B, de Carlos F, Silos-Santiago I, del Valle ME, Cobo J, Vega JA. 2008. Characterization of sensory deficits in TrkB knockout mice. Neurosci Lett 433: 43-47.
109. Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J, Heppenstall PA, Stucky CL, Mannsfeldt AG, Brennan TJ, Drummond HA, Qiao J, Benson CJ, Tarr DE, Hrstka RF, Yang B, Williamson RA, Welsh MJ. 2000. The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 407: 1007-1011.
110. Price MP, McIlwrath SL, Xie J, Cheng C, Qiao J, Tarr DE, Sluka KA, Brennan TJ, Lewin GR, Welsh MJ. 2001. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 32: 1071-1083.
111. Rahman F, Harada F, Saito I, Suzuki A, Kawano Y, Izumi K, Nozawa-Inoue K, Maeda T. 2011. Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors. Neurosci Lett 488: 173-177.
112. Reed-Geaghan EG, Maricich SM. 2011. Peripheral somatosensation: A touch of genetics. Curr Opin Genet Dev 21: 240-248.
113. Rice FL, Albrecht PJ. 2008. Cutaneous mechanisms of tactile perception: Morphological and chemical organization of the innervation to the skin. In: Basbaum AI, Kaneko A, Shepherd GM, Westheimer G, editors. The senses: A comprehensive reference, Vol. 6, Somatosensation (Gardner E, Kaas JH, volume editors). San Diego: Academic Press. pp. 1-32.
114. Roza C, Puel JL, Kress M, Baron A, Diochot S, Lazdunski M, Waldmann R. 2004. Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing. J Physiol 558(Pt 2): 659-669.
115. Rugiero F, Drew LJ, Wood JN. 2010. Kinetic properties of mechanically activated currents in spinal sensory neurons. J Physiol 588(Pt 2): 301-314.
116. Sabbadinia M, Yost CS. 2009. Molecular biology of background K channels: Insights from K2P knockout mice. J Mol Biol 385: 1331-1344.
117. Sachs F. 2010. Stretch-activated ion channels: What are they? Physiology (Bethesda) 25: 50-56.
118. Sames K, Halata Z, Jojovic M, van Damme EJ, Peumans WJ, Delpech B, Asmus B, Schumacher U. 2001. Lectin and proteoglycan histochemistry of feline pacinian corpuscles. J Histochem Cytochem 49: 19-28.
119. Scott A, Hasegawa H, Sakurai K, Yaron A, Cobb J, Wang F. 2011. Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. J Neurosci 31: 6741-6749.
120. Sedý J, Szeder V, Walro JM, Ren ZG, Nanka O, Tessarollo L, Sieber-Blum M, Grim M, Kucera J. 2004. Pacinian corpuscles development involves multiple Trk signaling pathways. Dev Dyn 231: 551-563.
121. Silver FH, Siperko LM. 2003. Mechanosensing and mechanochemical transduction: How is mechanical energy sensed and converted into chemical energy in an extracellular matrix? Crit Rev Biomed Eng 31: 255-331.
122. Smith ES, Lewin GR. 2009. Nociceptors: A phylogenetic view. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195: 1089-1106.
123. Staniland AA, McMahon SB. 2009. Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test. Eur J Pain 13: 554-563.
124. Sukharev S, Anishkin A. 2004. Mechanosensitive channels: What can we learn from 'simple' model systems? Trends Neurosci 27: 345-351.
125. Sukharev S, Corey DP. 2004. Mechanosensitive channels: Multiplicity of families and gating paradigms. Sci STKE 219: re4.
126. Suzuki H, Kerr R, Bianchi L, Frøkjaer-Jensen C, Slone D, Xue J, Gerstbrein B, Driscoll M, Schafer WR. 2003a. In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron 39: 1005-1017.
127. Suzuki M, Watanabe Y, Oyama Y, Mizuno A, Kusano E, Hirao A, Ookawara S. 2003b. Localization of mechanosensitive channel TRPV4 in mouse skin. Neurosci Lett 353: 189-192.
128. Tamura S, Morikawa Y, Senba E. 2005. TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience 130: 223-228.
129. Tsunozaki M, Bautista DM. 2009. Mammalian somatosensory mechanotransduction. Curr Opin Neurobiol 19: 362-369.
130. Van Keymeulen A, Mascre G, Youseff KK, Harel I, Michaux C, De Geest N, Szpalski C, Achouri Y, Bloch W, Hassan BA, Blanpain C. 2009. Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol 187: 91-100.
131. Vega JA, Esteban I, Naves FJ, del Valle ME, Malinovsky L. 1995. Immunohistochemical localization of laminin and type IV collagen in human cutaneous sensory nerve formations. Anat Embryol 191: 33-39.
132. Vega JA, Haro JJ, Del Valle ME. 1996. Immunohistochemistry of human cutaneous Meissner and pacinian corpuscles. Microsc Res Tech 34: 351-361.
133. Vega JA, García-Suárez O, Montaño JA, Pardo B, Cobo JM. 2009. The Meissner and Pacinian sensory corpuscles revisited new data from the last decade. Microsc Res Tech 72: 299-309.
134. Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M. 1997. A proton-gated cation channel involved in acid-sensing. Nature 386: 173-177.
135. Wang YY, Chang RB, Waters HN, McKemy DD, Liman ER. 2008. The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem 283: 32691-32703.
136. Welsh MJ, Price MP, Xie J. 2002. Biochemical basis of touch perception: Mechanosensory function of degenerin/epithelial Na+ channels. J Biol Chem 277: 2369-2372.
137. Wetzel C, Hu J, Riethmacher D, Benckendorff A, Harder L, Eilers A, Moshourab R, Kozlenkov A, Labuz D, Caspani O, Erdmann B, Machelska H, Heppenstall PA, Lewin GR. 2007. A stomatin-domain protein essential for touch sensation in the mouse. Nature 445: 206-209.
138. Wiggins P, Phillips R. 2005. Membrane-protein interactions in mechanosensitive channels. Biophys J 88: 880-902.
139. Yin J, Kuebler WM. 2010. Mechanotransduction by TRP channels: General concepts and specific role in the vasculature. Cell Biochem Biophys 56: 1-18.
140. Yoo S, Liu J, Sabbadini P, Au P, Xie GX, Yost CS. 2009. Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system. Neurosci Lett 465: 79-84.
141. Yost CS. 2003. Update on tandem pore (2P) domain K+ channels. Curr Drug Targets 4: 347-351.
142. Zhang XF, Chen J, Faltynek CR, Moreland RB, Neelands TR. 2008. Transient receptor potential A1 mediates an osmotically activated ion channel. Eur J Neurosci 27: 605-611.
143. Zelena J. 1994. Nerves and mechanoreceptors. London: Chapman & Hall.
144. Zylka MJ, Rice FL, Anderson DJ. 2005. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45: 17-25.