Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development

American Journal of Pathology

Volumn 158, Issue 5, 2001, Pages 1571-1578

  Gottschalk, Detlev ^a,b   Fehn, Marita ^c   Patt, Stephan ^d   Saeger, Wolfgang ^c   Kirchner, Thomas ^a   Aigner, Thomas ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c Marienkrankenhaus ^*  (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; CELL PROTEIN; COLLAGEN TYPE 2; GENE PRODUCT; PROTEOGLYCAN;

ARTICLE; CARCINOGENESIS; CARTILAGE CELL; CELL DIFFERENTIATION; CHORDOMA; CONTROLLED STUDY; DEVELOPMENT; GENE EXPRESSION; HUMAN; HUMAN TISSUE; NOTOCHORD; NUCLEUS PULPOSUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0035016641     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64111-9     Document Type: Article

References (58)

1. Über das Vorkommen von Resten der Chorda Dorsalis bei Menschen nach der Geburt und über die Verhältnisse zu den Gallertgesschwülsten am Clivus
2. Chordomas and cartilaginous tumors at the skull base
3. Chondroid chordoma: A low-grade chondrosarcoma
4. Collagen in the ageing human intervertebral disc: An increase in covalently bound fluorophores and chromophores
5. Does chondroid chordoma exist?
6. Chondroid chordomas and low-grade chondrosarcomas of the craniospinal axis
7. Chondroid chordoma
8. Chondroid chordoma
9. Ultrastructure of the so-called "chordoid sarcoma"
10. A comparative ultrastructural study of chondrosarcoma, chordoid sarcoma, and chordoma
11. Ultrastructural observations of a chordoma arising in the clivus
12. Immunohistochemical study in chordomas
13. Keratin subsets and monoclonal antibody HBME-1 in chordoma: Immunohistochemical differential diagnosis between tumors simulating chordoma
14. Chondroid chordoma - A variant of chordoma. A morphologic and immunohistochemical study
15. Demonstration of cytokeratins and an epithelial membrane antigen in chordomas and human fetal notochord
16. Epithelial-mesenchymal differentiation and extracellular matrix gene expression in pleomorphic adenomas of the salivary glands
17. Expression of collagen types IX and XI as well as other major cartilage matrix components by human fetal chondrocytes in vivo
18. Cytogenetics and molecular genetics of bone and soft tissue tumors
19. Extracellular matrix composition and gene expression in collagenous colitis
20. Chain-specific keratin profile of epithelioid soft-tissue sarcomas
21. Immunohistochemical distinction of classic and chondroid chordomas
22. Chordoma: An immunohistologic study
23. Demonstration of cytokeratins and an epithelial membrane antigen in chondroid chordoma
24. Collagenous and basement proteins of chordoma: Immunohistochemical analysis
25. Expression of cytokeratin and vimentin in nucleus pulposus cells
26. Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age
27. Types I and II collagens in intervertebral disc
28. Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages
29. Chondroid chordoma of the sacrococcygeal region
30. Lectin histochemistry of human fetal notochord, echordosis physaliphora, and chordomas
31. Biochemical studies of the matrix of craniovertebral chordoma and a metastasis
32. Histochemical characterization of mucosubstances in bone and soft tissue tumors
33. Chondrocyte differentiation
34. Type of collagen in chordoma
35. Isolation of human type X collagen and immunolocalization in fetal cartilage
36. 2+ binding properties of type X collagen
37. Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration
38. Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasms
39. Variation with age in the pattern of type X collagen expression in normal and scoliotic human intervertebral discs
40. Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms
41. Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis
42. Near-haploidy and subsequent polyploidization characterize the progression of peripheral chondrosarcoma
43. Loss of heterozygosity and DNA ploidy point to a diverging genetic mechanism in the origin of peripheral and central chondrosarcoma
44. Cytogenetic, telomere, and telomerase studies in five surgically managed lumbosacral chordomas
45. Cytogenetic and molecular cytogenetic analysis of sacral chordoma
46. Cytogenetics of sacral chordoma
47. Clonal chromosome aberrations in three sacral chordomas
48. Clonal chromosome abnormalities in enchondromas and chondrosarcomas
49. Chromosome 9 related aberrations and deletions of the CDKN2 and MTS 2 putative tumor suppressor genes in human chondrosarcomas
50. Frequent loss of heterozygosity for markers on chromosome arm 10q in chondrosarcomas
51. Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas
52. Chondrocytic cell differentiation in clear cell chondrosarcoma
53. Clear cell tumors of bone
54. Intracranial chordomas: A clinicopathological and prognostic study of 51 cases
55. Reactivity of monoclonal anti type II collagen antibodies with cartilage and synovial tissue in rheumatoid arthritis and osteoarthritis
56. Structure of recombinant N-terminal globule of type VI collagen α3 chain and its binding to heparin and hyaluronan
57. Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies