MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability

eLife

Volumn 2014, Issue 3, 2014, Pages

  Choi, Young Eun ^a   Pan, Yunfeng ^a   Park, Eunmi ^a   Konstantinopoulos, Panagiotis A ^a   De, Subhajyoti ^b,c   D'Andrea, Alan D ^a   Chowdhury, Dipanjan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; MICRORNA; MICRORNA 1255B; MICRORNA 148B; MICRORNA 193B; OLAPARIB; RAD51 PROTEIN; UNCLASSIFIED DRUG; VELIPARIB; ENZYME INHIBITOR; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ARTICLE; CELL CYCLE G1 PHASE; CELL SYNCHRONIZATION; CELL VIABILITY; CHROMOSOME ABERRATION; CLONOGENIC ASSAY; COLORIMETRY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MUTATION; OVARY TUMOR; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; RECOMBINATION REPAIR; TRIPLE NEGATIVE BREAST CANCER; TUMOR CELL LINE;

BASE SEQUENCE; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE LIBRARY; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMANS; LOSS OF HETEROZYGOSITY; MICRORNAS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; RECOMBINATIONAL DNA REPAIR; RNA, MESSENGER; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84899865106     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02445     Document Type: Article

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