Efficient purification of active bufadienolides by a class separation method based on hydrophilic solid-phase extraction and reversed-phase high performance liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis

Volumn 97, Issue , 2014, Pages 54-64

  Li, Xiaolong ^a,b,c   Liu, Yanfang ^a   Shen, Aijin ^a   Wang, Chaoran ^a   Yan, Jingyu ^a   Zhao, Weijie ^b   Liang, Xinmiao ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Active bufadienolides; Class separation; Hydrophilic solid phase extraction; Purification; Toad skin

Indexed keywords

AMINO ACID CONJUGATED BUFADIENOLIDE; AMINO ACID UNCONJUGATED BUFADIENOLIDE; BUFADIENOLIDE DERIVATIVE; CARBON 13; UNCLASSIFIED DRUG;

ARTICLE; BUFO BUFO; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG PURIFICATION; HYDROPHILIC INTERACTION CHROMATOGRAPHY; HYDROPHILICITY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; SKIN; SOLID PHASE EXTRACTION; ANIMAL; CHEMISTRY; CHINESE MEDICINE; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES;

ANIMALS; BUFANOLIDES; BUFO BUFO; CHROMATOGRAPHY, REVERSE-PHASE; MAGNETIC RESONANCE SPECTROSCOPY; MEDICINE, CHINESE TRADITIONAL; SKIN; SOLID PHASE EXTRACTION;

EID: 84899842849     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.04.015     Document Type: Article

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