-
1
-
-
2342509057
-
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
-
J. An, D.M. Muoio, M. Shiota, Y. Fujimoto, G.W. Cline, G.I. Shulman, T.R. Koves, R. Stevens, D. Millington, and C.B. Newgard Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance Nat. Med. 10 2004 268 274
-
(2004)
Nat. Med.
, vol.10
, pp. 268-274
-
-
An, J.1
Muoio, D.M.2
Shiota, M.3
Fujimoto, Y.4
Cline, G.W.5
Shulman, G.I.6
Koves, T.R.7
Stevens, R.8
Millington, D.9
Newgard, C.B.10
-
2
-
-
0024691998
-
Brown adipose tissue: Structure and function
-
E. Arbuthnott Brown adipose tissue: structure and function Proc. Nutr. Soc. 48 1989 177 182
-
(1989)
Proc. Nutr. Soc.
, vol.48
, pp. 177-182
-
-
Arbuthnott, E.1
-
3
-
-
0019457057
-
In vivo studies of carnitine and fatty acid metabolism: Problems with use of anesthetics
-
E.P. Brass, and C.L. Hoppel In vivo studies of carnitine and fatty acid metabolism: problems with use of anesthetics Anal. Biochem. 110 1981 77 81
-
(1981)
Anal. Biochem.
, vol.110
, pp. 77-81
-
-
Brass, E.P.1
Hoppel, C.L.2
-
4
-
-
0026728161
-
Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart
-
T.L. Broderick, H.A. Quinney, and G.D. Lopaschuk Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart J. Biol. Chem. 267 1992 3758 3763
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 3758-3763
-
-
Broderick, T.L.1
Quinney, H.A.2
Lopaschuk, G.D.3
-
5
-
-
0242362630
-
Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns
-
D.H. Chace, T.A. Kalas, and E.W. Naylor Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns Clin. Chem. 49 2003 1797 1817
-
(2003)
Clin. Chem.
, vol.49
, pp. 1797-1817
-
-
Chace, D.H.1
Kalas, T.A.2
Naylor, E.W.3
-
6
-
-
33846892749
-
The genetic landscape of type 2 diabetes in mice
-
S.M. Clee, and A.D. Attie The genetic landscape of type 2 diabetes in mice Endocr. Rev. 28 2007 48 83
-
(2007)
Endocr. Rev.
, vol.28
, pp. 48-83
-
-
Clee, S.M.1
Attie, A.D.2
-
7
-
-
0344069640
-
Dynamic changes of plasma acylcarnitine levels induced by fasting and sunflower oil challenge test in children
-
C.G. Costa, I.T. De Almeida, and C. Jacobs Dynamic changes of plasma acylcarnitine levels induced by fasting and sunflower oil challenge test in children Pediatr. Res. 46 1999 440 444
-
(1999)
Pediatr. Res.
, vol.46
, pp. 440-444
-
-
Costa, C.G.1
De Almeida, I.T.2
Jacobs, C.3
-
8
-
-
0020040724
-
Chemical energetics of slow- and fast-twitch muscles of the mouse
-
M.T. Crow, and M.J. Kushmerick Chemical energetics of slow- and fast-twitch muscles of the mouse J. Gen. Physiol. 79 1982 147 166
-
(1982)
J. Gen. Physiol.
, vol.79
, pp. 147-166
-
-
Crow, M.T.1
Kushmerick, M.J.2
-
9
-
-
84885992782
-
10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species
-
L.J. den Hartigh, C.Y. Han, S. Wang, M. Omer, and A. Chait 10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species J. Lipid Res. 54 2013 2964 2978
-
(2013)
J. Lipid Res.
, vol.54
, pp. 2964-2978
-
-
Den Hartigh, L.J.1
Han, C.Y.2
Wang, S.3
Omer, M.4
Chait, A.5
-
10
-
-
38849194111
-
Intramyocellular lipids: Maker vs. Marker of insulin resistance
-
Z. Guo Intramyocellular lipids: maker vs. marker of insulin resistance Med. Hypotheses 70 2008 625 629
-
(2008)
Med. Hypotheses
, vol.70
, pp. 625-629
-
-
Guo, Z.1
-
11
-
-
84860493578
-
Lipid mediators of insulin resistance
-
W.L. Holland, T.A. Knotts, J.A. Chavez, L.P. Wang, K.L. Hoehn, and S.A. Summers Lipid mediators of insulin resistance Nutr. Rev. 65 2007 S39 S46
-
(2007)
Nutr. Rev.
, vol.65
-
-
Holland, W.L.1
Knotts, T.A.2
Chavez, J.A.3
Wang, L.P.4
Hoehn, K.L.5
Summers, S.A.6
-
12
-
-
0019015876
-
Carnitine metabolism in normal-weight and obese human subjects during fasting
-
C.L. Hoppel, and S.M. Genuth Carnitine metabolism in normal-weight and obese human subjects during fasting Am. J. Physiol. 238 1980 E409 E415
-
(1980)
Am. J. Physiol.
, vol.238
-
-
Hoppel, C.L.1
Genuth, S.M.2
-
13
-
-
33751208636
-
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
-
S. Horvath, B. Zhang, M. Carlson, K.V. Lu, S. Zhu, R.M. Felciano, M.F. Laurance, W. Zhao, S. Qi, Z. Chen, Y. Lee, A.C. Scheck, L.M. Liau, H. Wu, D.H. Geschwind, P.G. Febbo, H.I. Kornblum, T.F. Cloughesy, S.F. Nelson, and P.S. Mischel Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target Proc. Natl. Acad. Sci. U. S. A. 103 2006 17402 17407
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 17402-17407
-
-
Horvath, S.1
Zhang, B.2
Carlson, M.3
Lu, K.V.4
Zhu, S.5
Felciano, R.M.6
Laurance, M.F.7
Zhao, W.8
Qi, S.9
Chen, Z.10
Lee, Y.11
Scheck, A.C.12
Liau, L.M.13
Wu, H.14
Geschwind, D.H.15
Febbo, P.G.16
Kornblum, H.I.17
Cloughesy, T.F.18
Nelson, S.F.19
Mischel, P.S.20
more..
-
14
-
-
0020636181
-
The effect of electrical stimulation, fasting and anesthesia on the carnitine(s) and acyl-carnitines of rat white and red skeletal muscle fibres
-
J. Kerner, and L.L. Bieber The effect of electrical stimulation, fasting and anesthesia on the carnitine(s) and acyl-carnitines of rat white and red skeletal muscle fibres Comp. Biochem. Physiol. B 75 1983 311 316
-
(1983)
Comp. Biochem. Physiol. B
, vol.75
, pp. 311-316
-
-
Kerner, J.1
Bieber, L.L.2
-
15
-
-
79551497655
-
Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects
-
C.L. Kien, K.I. Everingham, D. Stevens, N.K. Fukagawa, and D.M. Muoio Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects Obesity 19 2011 305 311
-
(2011)
Obesity
, vol.19
, pp. 305-311
-
-
Kien, C.L.1
Everingham, K.I.2
Stevens, D.3
Fukagawa, N.K.4
Muoio, D.M.5
-
17
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
T.R. Koves, J.R. Ussher, R.C. Noland, D. Slentz, M. Mosedale, O. Ilkayeva, J. Bain, R. Stevens, J.R. Dyck, C.B. Newgard, G.D. Lopaschuk, and D.M. Muoio Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance Cell Metab. 7 2008 45 56
-
(2008)
Cell Metab.
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
Slentz, D.4
Mosedale, M.5
Ilkayeva, O.6
Bain, J.7
Stevens, R.8
Dyck, J.R.9
Newgard, C.B.10
Lopaschuk, G.D.11
Muoio, D.M.12
-
18
-
-
60549111634
-
WGCNA: An R package for weighted correlation network analysis
-
R. Langfelder, and S. Horvath WGCNA: an R package for weighted correlation network analysis BMC Bioinforma. 9 2008
-
(2008)
BMC Bioinforma.
, vol.9
-
-
Langfelder, R.1
Horvath, S.2
-
19
-
-
33750846938
-
Mechanisms of the depot specificity of peroxisome proliferator activated receptor gamma action on adipose tissue metabolism
-
M. Laplante, W.T. Festuccia, G. Soucy, Y. Gélinas, J. Lalonde, J.P. Berger, and Y. Deshaies Mechanisms of the depot specificity of peroxisome proliferator activated receptor gamma action on adipose tissue metabolism Diabetes 55 2006 2771 2778
-
(2006)
Diabetes
, vol.55
, pp. 2771-2778
-
-
Laplante, M.1
Festuccia, W.T.2
Soucy, G.3
Gélinas, Y.4
Lalonde, J.5
Berger, J.P.6
Deshaies, Y.7
-
20
-
-
77956094483
-
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity
-
S.J. Mihalik, B.H. Goodpaster, D.E. Kelley, D.H. Chace, J. Vockley, F.G. Toledo, and J.P. DeLany Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity Obesity (Silver Spring) 18 2010 1695 1700
-
(2010)
Obesity (Silver Spring)
, vol.18
, pp. 1695-1700
-
-
Mihalik, S.J.1
Goodpaster, B.H.2
Kelley, D.E.3
Chace, D.H.4
Vockley, J.5
Toledo, F.G.6
Delany, J.P.7
-
21
-
-
84876465920
-
Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding
-
M.K. Montgomery, N.L. Hallahan, S.H. Brown, M. Liu, T.W. Mitchell, G.J. Cooney, and N. Turner Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding Diabetologia 56 2013 1129 1139
-
(2013)
Diabetologia
, vol.56
, pp. 1129-1139
-
-
Montgomery, M.K.1
Hallahan, N.L.2
Brown, S.H.3
Liu, M.4
Mitchell, T.W.5
Cooney, G.J.6
Turner, N.7
-
22
-
-
42449152466
-
Lipid-induced metabolic dysfunction in skeletal muscle
-
D.M. Muoio, and T.R. Koves Lipid-induced metabolic dysfunction in skeletal muscle Novartis Found. Symp. 286 2007 24 38
-
(2007)
Novartis Found. Symp.
, vol.286
, pp. 24-38
-
-
Muoio, D.M.1
Koves, T.R.2
-
23
-
-
84860476829
-
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility
-
D.M. Muoio, R.C. Noland, J.P. Kovalik, S.E. Seiler, M.N. Davies, K.L. DeBalsi, O.R. Ilkayeva, R.D. Stevens, I. Kheterpal, J. Zhang, J.D. Covington, S. Bajpeyi, E. Ravussin, W. Kraus, T.R. Koves, and R.L. Mynatt Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility Cell Metab. 15 2012 764 777
-
(2012)
Cell Metab.
, vol.15
, pp. 764-777
-
-
Muoio, D.M.1
Noland, R.C.2
Kovalik, J.P.3
Seiler, S.E.4
Davies, M.N.5
Debalsi, K.L.6
Ilkayeva, O.R.7
Stevens, R.D.8
Kheterpal, I.9
Zhang, J.10
Covington, J.D.11
Bajpeyi, S.12
Ravussin, E.13
Kraus, W.14
Koves, T.R.15
Mynatt, R.L.16
-
24
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
C.B. Newgard, J. An, J.R. Bain, M.J. Muehlbauer, R.D. Stevens, L.F. Lien, A.M. Haqq, S.H. Shah, M. Arlotto, C.A. Slentz, J. Rochon, D. Gallup, O. Ilkayeva, B.R. Wenner, J. Yancy, H. Eisenson, G. Musante, R.S. Surwit, D.S. Millington, M.D. Butler, and L.P. Svetkey A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Cell Metab. 9 2009 311 326
-
(2009)
Cell Metab.
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
An, J.2
Bain, J.R.3
Muehlbauer, M.J.4
Stevens, R.D.5
Lien, L.F.6
Haqq, A.M.7
Shah, S.H.8
Arlotto, M.9
Slentz, C.A.10
Rochon, J.11
Gallup, D.12
Ilkayeva, O.13
Wenner, B.R.14
Yancy, J.15
Eisenson, H.16
Musante, G.17
Surwit, R.S.18
Millington, D.S.19
Butler, M.D.20
Svetkey, L.P.21
more..
-
25
-
-
84856579589
-
Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: Tailoring the organelle for optimal function
-
M. Picard, R.T. Hepple, and Y. Burelle Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function Am. J. Physiol. Cell Physiol. 302 2012 629 641
-
(2012)
Am. J. Physiol. Cell Physiol.
, vol.302
, pp. 629-641
-
-
Picard, M.1
Hepple, R.T.2
Burelle, Y.3
-
26
-
-
84856117079
-
Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity
-
M.A. Ramos-Roman, L. Sweetman, M.J. Valdez, and E.J. Parks Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity Metabolism 61 2012 202 212
-
(2012)
Metabolism
, vol.61
, pp. 202-212
-
-
Ramos-Roman, M.A.1
Sweetman, L.2
Valdez, M.J.3
Parks, E.J.4
-
27
-
-
79951713963
-
Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women
-
L.M. Redman, K.M. Huffman, L.R. Landerman, C.F. Pieper, J.R. Bain, M.J. Muehlbauer, R.D. Stevens, B.R. Wenner, V.B. Kraus, C.B. Newgard, W.E. Kraus, and E. Ravussin Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women J. Clin. Endocrinol. Metab. 96 2011 E312 E321
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
-
-
Redman, L.M.1
Huffman, K.M.2
Landerman, L.R.3
Pieper, C.F.4
Bain, J.R.5
Muehlbauer, M.J.6
Stevens, R.D.7
Wenner, B.R.8
Kraus, V.B.9
Newgard, C.B.10
Kraus, W.E.11
Ravussin, E.12
-
29
-
-
70449448312
-
Autophagy regulates adipose mass and differentiation in mice
-
R. Singh, Y. Xiang, Y. Wang, K. Baikati, A.M. Cuervo, Y.K. Luu, Y. Tang, J.E. Pessin, G.J. Schwartz, and M.J. Czaja Autophagy regulates adipose mass and differentiation in mice J. Clin. Invest. 119 2009 3329 3339
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3329-3339
-
-
Singh, R.1
Xiang, Y.2
Wang, Y.3
Baikati, K.4
Cuervo, A.M.5
Luu, Y.K.6
Tang, Y.7
Pessin, J.E.8
Schwartz, G.J.9
Czaja, M.J.10
-
30
-
-
65549106122
-
Muscle acylcarnitines during short-term fasting in lean healthy men
-
M.R. Soeters, H.P. Sauerwein, M. Duran, R.J. Wanders, M.T. Ackermans, E. Fliers, S.M. Houten, and M.J. Serlie Muscle acylcarnitines during short-term fasting in lean healthy men Clin. Sci. (Lond.) 116 2009 585 592
-
(2009)
Clin. Sci. (Lond.)
, vol.116
, pp. 585-592
-
-
Soeters, M.R.1
Sauerwein, H.P.2
Duran, M.3
Wanders, R.J.4
Ackermans, M.T.5
Fliers, E.6
Houten, S.M.7
Serlie, M.J.8
-
31
-
-
84862136104
-
Characterization of d-3-hydroxybutyrylcarnitine (ketocarnitine): An identified ketosis-induced metabolite
-
M.R. Soeters, M.J. Serlie, H.P. Sauerwein, M. Duran, J.P. Ruiter, W. Kulik, M.T. Ackermans, P.E. Minkler, C.L. Hoppel, R.J.A. Wanders, and S.M. Houten Characterization of d-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite Metabolism 61 2012 966 973
-
(2012)
Metabolism
, vol.61
, pp. 966-973
-
-
Soeters, M.R.1
Serlie, M.J.2
Sauerwein, H.P.3
Duran, M.4
Ruiter, J.P.5
Kulik, W.6
Ackermans, M.T.7
Minkler, P.E.8
Hoppel, C.L.9
Wanders, R.J.A.10
Houten, S.M.11
-
32
-
-
84871344348
-
Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation
-
M.R. Soeters, P.B. Soeters, M.G. Schooneman, S.M. Houten, and J.A. Romijn Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation Am. J. Physiol. Endocrinol. Metab. 303 2012 E1397 E1407
-
(2012)
Am. J. Physiol. Endocrinol. Metab.
, vol.303
-
-
Soeters, M.R.1
Soeters, P.B.2
Schooneman, M.G.3
Houten, S.M.4
Romijn, J.A.5
-
33
-
-
0035936764
-
Obesity and the regulation of energy balance
-
B.M. Spiegelman, and J.S. Flier Obesity and the regulation of energy balance Cell 104 2001 531 543
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
34
-
-
43949150714
-
Energy metabolism of the heart: From basic concepts to clinical applications
-
H. Taegtmeyer Energy metabolism of the heart: from basic concepts to clinical applications Curr. Probl. Cardiol. 19 1994 61 113
-
(1994)
Curr. Probl. Cardiol.
, vol.19
, pp. 61-113
-
-
Taegtmeyer, H.1
-
35
-
-
0036087393
-
Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle
-
T. Tyni, M. Pourfarzam, and D.M. Turnbull Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle Pediatr. Res. 52 2002 64 70
-
(2002)
Pediatr. Res.
, vol.52
, pp. 64-70
-
-
Tyni, T.1
Pourfarzam, M.2
Turnbull, D.M.3
-
37
-
-
0036471216
-
Carnitine biosynthesis in mammals
-
F.M. Vaz, and R.J.A. Wanders Carnitine biosynthesis in mammals Biochem. J. 361 2002 417 429
-
(2002)
Biochem. J.
, vol.361
, pp. 417-429
-
-
Vaz, F.M.1
Wanders, R.J.A.2
-
38
-
-
0033001744
-
Quantitative plasma acylcarnitine analysis using electrospray tandem mass spectrometry for the diagnosis of organic acidaemias and fatty acid oxidation defects
-
P. Vreken, A.E. van Lint, A.H. Bootsma, H. Overmars, R.J. Wanders, and A.H. van Gennip Quantitative plasma acylcarnitine analysis using electrospray tandem mass spectrometry for the diagnosis of organic acidaemias and fatty acid oxidation defects J. Inherit. Metab. Dis. 3 1999 302 306
-
(1999)
J. Inherit. Metab. Dis.
, vol.3
, pp. 302-306
-
-
Vreken, P.1
Van Lint, A.E.2
Bootsma, A.H.3
Overmars, H.4
Wanders, R.J.5
Van Gennip, A.H.6
-
39
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
T.J. Wang, M.G. Larson, R.S. Vasan, S. Cheng, E.P. Rhee, E. McCabe, G.D. Lewis, C.S. Fox, P.F. Jacques, C. Fernandez, C.J. O'Donnell, S.A. Carr, V.K. Mootha, J.C. Florez, A. Souza, O. Melander, C.B. Clish, and R.E. Gerszten Metabolite profiles and the risk of developing diabetes Nat. Med. 17 2011 448 453
-
(2011)
Nat. Med.
, vol.17
, pp. 448-453
-
-
Wang, T.J.1
Larson, M.G.2
Vasan, R.S.3
Cheng, S.4
Rhee, E.P.5
McCabe, E.6
Lewis, G.D.7
Fox, C.S.8
Jacques, P.F.9
Fernandez, C.10
O'Donnell, C.J.11
Carr, S.A.12
Mootha, V.K.13
Florez, J.C.14
Souza, A.15
Melander, O.16
Clish, C.B.17
Gerszten, R.E.18
-
40
-
-
84864479791
-
MetaboAnalyst 2.0 - A comprehensive server for metabolomic data analysis
-
J. Xia, R. Mandal, I.V. Sinelnikov, D. Broadhurst, and D.S. Wishart MetaboAnalyst 2.0 - a comprehensive server for metabolomic data analysis Nucleic Acids Res. 40 2012 W127 W133
-
(2012)
Nucleic Acids Res.
, vol.40
-
-
Xia, J.1
Mandal, R.2
Sinelnikov, I.V.3
Broadhurst, D.4
Wishart, D.S.5
-
41
-
-
67849106535
-
MetaboAnalyst: A web server for metabolomic data analysis and interpretation
-
J. Xia, N. Psychogios, N. Young, and D.S. Wishart MetaboAnalyst: a web server for metabolomic data analysis and interpretation Nucleic Acids Res. 37 2009 W652 W660
-
(2009)
Nucleic Acids Res.
, vol.37
-
-
Xia, J.1
Psychogios, N.2
Young, N.3
Wishart, D.S.4
-
42
-
-
33847129641
-
Gene network interconnectedness and the generalized topological overlap measure
-
A. Yip, and S. Horvath Gene network interconnectedness and the generalized topological overlap measure BMC Bioinforma. 8 2007 22
-
(2007)
BMC Bioinforma.
, vol.8
, pp. 22
-
-
Yip, A.1
Horvath, S.2
-
43
-
-
23944458138
-
A general framework for weighted gene co-expression network analysis
-
B. Zhang, and S. Horvath A general framework for weighted gene co-expression network analysis Stat. Appl. Genet. Mol. Biol. 4 2005
-
(2005)
Stat. Appl. Genet. Mol. Biol.
, vol.4
-
-
Zhang, B.1
Horvath, S.2
|