-
1
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton, J.D., Goldstein, J.L., and Brown, M.S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131
-
(2002)
J. Clin. Invest
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
2
-
-
0036047655
-
Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism
-
Shimano, H. (2002) Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism. Vitam. Horm. 65, 167-194
-
(2002)
Vitam. Horm
, vol.65
, pp. 167-194
-
-
Shimano, H.1
-
3
-
-
0032104180
-
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
-
Horton, J.D., Shimomura, I., Brown, M.S., Hammer, R.E., Goldstein, J.L., and Shimano, H. (1998) Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 101, 2331-2339
-
(1998)
J. Clin. Invest
, vol.101
, pp. 2331-2339
-
-
Horton, J.D.1
Shimomura, I.2
Brown, M.S.3
Hammer, R.E.4
Goldstein, J.L.5
Shimano, H.6
-
4
-
-
0032568557
-
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
-
Horton, J.D., Bashmakov, Y., Shimomura, I., and Shimano, H. (1998) Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. USA. 95, 5987-5992
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 5987-5992
-
-
Horton, J.D.1
Bashmakov, Y.2
Shimomura, I.3
Shimano, H.4
-
5
-
-
0030904931
-
Identification of glycerol- 3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene
-
Ericsson, J., Jackson, S.M., Kim, J.B., Spiegelman, B.M., and Edwards, P.A. (1997) Identification of glycerol- 3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. J. Biol. Chem. 272, 7298-7305
-
(1997)
J. Biol. Chem
, vol.272
, pp. 7298-7305
-
-
Ericsson, J.1
Jackson, S.M.2
Kim, J.B.3
Spiegelman, B.M.4
Edwards, P.A.5
-
6
-
-
0034879757
-
CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene
-
Kast, H.R., Nguyen, C.M., Anisfeld, A.M., Ericsson, J., and Edwards, P.A. (2001) CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene. J. Lipid Res. 42, 1266-1272
-
(2001)
J. Lipid Res
, vol.42
, pp. 1266-1272
-
-
Kast, H.R.1
Nguyen, C.M.2
Anisfeld, A.M.3
Ericsson, J.4
Edwards, P.A.5
-
7
-
-
0029797604
-
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
-
Shimano, H., Horton, J.D., Hammer, R.E., Shimomura, I., Brown, M.S., and Goldstein, J.L. (1996) Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 98, 1575-1584
-
(1996)
J. Clin. Invest
, vol.98
, pp. 1575-1584
-
-
Shimano, H.1
Horton, J.D.2
Hammer, R.E.3
Shimomura, I.4
Brown, M.S.5
Goldstein, J.L.6
-
8
-
-
0030604717
-
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
-
Sakai, J., Duncan, E.A., Rawson, R.B., Hua, X., Brown, M.S., and Goldstein, J.L. (1996) Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85, 1037-1046
-
(1996)
Cell
, vol.85
, pp. 1037-1046
-
-
Sakai, J.1
Duncan, E.A.2
Rawson, R.B.3
Hua, X.4
Brown, M.S.5
Goldstein, J.L.6
-
9
-
-
47049092561
-
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
-
Bennett, M.K., Seo, Y.K., Datta, S., Shin, D.J., and Osborne, T.F. (2008) Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. J. Biol. Chem. 283, 15628-15637
-
(2008)
J. Biol. Chem
, vol.283
, pp. 15628-15637
-
-
Bennett, M.K.1
Seo, Y.K.2
Datta, S.3
Shin, D.J.4
Osborne, T.F.5
-
10
-
-
0028839010
-
Independent regulation of sterol regulatory element- binding proteins 1 and 2 in hamster liver
-
Sheng, Z., Otani, H., Brown, M.S., and Goldstein, J.L. (1995) Independent regulation of sterol regulatory element- binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA 92, 935-938
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 935-938
-
-
Sheng, Z.1
Otani, H.2
Brown, M.S.3
Goldstein, J.L.4
-
11
-
-
14144251157
-
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c
-
Hegarty, B.D., Bobard, A., Hainault, I., Ferre , P., Bossard, P., and Foufelle, F. (2005) Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc. Natl. Acad. Sci. USA 102, 791-796
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 791-796
-
-
Hegarty, B.D.1
Bobard, A.2
Hainault, I.3
Ferre, P.4
Bossard, P.5
Foufelle, F.6
-
12
-
-
0036846040
-
Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms
-
Xu, J., Cho, H., OMalley, S., Park, J.H., and Clarke, S.D. (2002) Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. J. Nutr. 132, 3333-3339
-
(2002)
J. Nutr
, vol.132
, pp. 3333-3339
-
-
Xu, J.1
Cho, H.2
Omalley, S.3
Park, J.H.4
Clarke, S.D.5
-
13
-
-
0033544869
-
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
-
Yahagi, N., Shimano, H., Hasty, A.H., Amemiya-Kudo, M., Okazaki, H., Tamura, Y., Iizuka, Y., Shionoiri, F., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Nagai, R., Ishibashi, S., and Yamada, N. (1999) A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J. Biol. Chem. 274, 35840-35844
-
(1999)
J. Biol. Chem
, vol.274
, pp. 35840-35844
-
-
Yahagi, N.1
Shimano, H.2
Hasty, A.H.3
Amemiya-Kudo, M.4
Okazaki, H.5
Tamura, Y.6
Iizuka, Y.7
Shionoiri, F.8
Ohashi, K.9
Osuga, J.10
Harada, K.11
Gotoda, T.12
Nagai, R.13
Ishibashi, S.14
Yamada, N.15
-
14
-
-
0345448923
-
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
-
Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J., Yamada, N., and Shimano, H. (2003) Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 38, 1529-1539
-
(2003)
Hepatology
, vol.38
, pp. 1529-1539
-
-
Sekiya, M.1
Yahagi, N.2
Matsuzaka, T.3
Najima, Y.4
Nakakuki, M.5
Nagai, R.6
Ishibashi, S.7
Osuga, J.8
Yamada, N.9
Shimano, H.10
-
15
-
-
0035830840
-
Unsaturated fatty acids downregulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells
-
Hannah, V.C., Ou, J., Luong, A., Goldstein, J.L., and Brown, M.S. (2001) Unsaturated fatty acids downregulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J. Biol. Chem. 276, 4365-4372
-
(2001)
J. Biol. Chem
, vol.276
, pp. 4365-4372
-
-
Hannah, V.C.1
Ou, J.2
Luong, A.3
Goldstein, J.L.4
Brown, M.S.5
-
16
-
-
77951218102
-
Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein- 1 through proteolytic processing and autoloop regulatory circuit
-
Takeuchi, Y., Yahagi, N., Izumida, Y., Nishi, M., Kubota, M., Teraoka, Y., Yamamoto, T., Matsuzaka, T., Nakagawa, Y., Sekiya, M., Iizuka, Y., Ohashi, K., Osuga, J., Gotoda, T., Ishibashi, S., Itaka, K., Kataoka, K., Nagai, R., Yamada, N., Kadowaki, T., and Shimano, H. (2010) Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein- 1 through proteolytic processing and autoloop regulatory circuit. J. Biol. Chem. 285, 11681-11691
-
(2010)
J. Biol. Chem
, vol.285
, pp. 11681-11691
-
-
Takeuchi, Y.1
Yahagi, N.2
Izumida, Y.3
Nishi, M.4
Kubota, M.5
Teraoka, Y.6
Yamamoto, T.7
Matsuzaka, T.8
Nakagawa, Y.9
Sekiya, M.10
Iizuka, Y.11
Ohashi, K.12
Osuga, J.13
Gotoda, T.14
Ishibashi, S.15
Itaka, K.16
Kataoka, K.17
Nagai, R.18
Yamada, N.19
Kadowaki, T.20
Shimano, H.21
more..
-
17
-
-
0032489460
-
Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein Evidence from in vivo competition studies
-
Sakai, J., Nohturfft, A., Goldstein, J.L., and Brown, M.S. (1998) Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J. Biol. Chem. 273, 5785-5793
-
(1998)
J. Biol. Chem
, vol.273
, pp. 5785-5793
-
-
Sakai, J.1
Nohturfft, A.2
Goldstein, J.L.3
Brown, M.S.4
-
18
-
-
0030911517
-
Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2
-
Duncan, E.A., Brown, M.S., Goldstein, J.L., and Sakai, J. (1997) Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2. J. Biol. Chem. 272, 12778-12785
-
(1997)
J. Biol. Chem
, vol.272
, pp. 12778-12785
-
-
Duncan, E.A.1
Brown, M.S.2
Goldstein, J.L.3
Sakai, J.4
-
19
-
-
0029878960
-
Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane
-
Hua, X., Sakai, J., Brown, M.S., and Goldstein, J.L. (1996) Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane. J. Biol. Chem. 271, 10379-10384
-
(1996)
J. Biol. Chem
, vol.271
, pp. 10379-10384
-
-
Hua, X.1
Sakai, J.2
Brown, M.S.3
Goldstein, J.L.4
-
20
-
-
0028978248
-
Purification of an interleukin-1b converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains
-
Wang, X., Pai, J.T., Wiedenfeld, E.A., Medina, J.C., Slaughter, C.A., Goldstein, J.L., and Brown, M.S. (1995) Purification of an interleukin-1b converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. J. Biol. Chem. 270, 18044-18050
-
(1995)
J. Biol. Chem
, vol.270
, pp. 18044-18050
-
-
Wang, X.1
Pai, J.T.2
Wiedenfeld, E.A.3
Medina, J.C.4
Slaughter, C.A.5
Goldstein, J.L.6
Brown, M.S.7
-
21
-
-
0029871920
-
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis
-
Wang, X., Zelenski, N.G., Yang, J., Sakai, J., Brown, M.S., and Goldstein, J.L. (1996) Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 15, 1012-1020
-
(1996)
EMBO J
, vol.15
, pp. 1012-1020
-
-
Wang, X.1
Zelenski, N.G.2
Yang, J.3
Sakai, J.4
Brown, M.S.5
Goldstein, J.L.6
-
22
-
-
0032805251
-
Hydrodynamicsbased transfection in animals by systemic administration of plasmid DNA
-
Liu, F., Song, Y., and Liu, D. (1999) Hydrodynamicsbased transfection in animals by systemic administration of plasmid DNA. Gene Ther. 6, 1258-1266
-
(1999)
Gene Ther
, vol.6
, pp. 1258-1266
-
-
Liu, F.1
Song, Y.2
Liu, D.3
-
23
-
-
0036792050
-
Insig- 2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory elementbinding proteins
-
Yabe, D., Brown, M.S., and Goldstein, J.L. (2002) Insig- 2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory elementbinding proteins. Proc. Natl. Acad. Sci. USA 99, 12753-12758
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12753-12758
-
-
Yabe, D.1
Brown, M.S.2
Goldstein, J.L.3
-
24
-
-
0037162719
-
Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
-
Yang, T., Espenshade, P.J., Wright, M.E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J.L., and Brown, M.S. (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110, 489-500
-
(2002)
Cell
, vol.110
, pp. 489-500
-
-
Yang, T.1
Espenshade, P.J.2
Wright, M.E.3
Yabe, D.4
Gong, Y.5
Aebersold, R.6
Goldstein, J.L.7
Brown, M.S.8
-
25
-
-
0034705287
-
Sorting and signaling at the Golgi complex
-
Donaldson, J.G. and Lippincott-Schwartz, J. (2000) Sorting and signaling at the Golgi complex. Cell 101, 693-696
-
(2000)
Cell
, vol.101
, pp. 693-696
-
-
Donaldson, J.G.1
Lippincott-Schwartz, J.2
-
26
-
-
0033599028
-
Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
-
DeBose-Boyd, R.A., Brown, M.S., Li, W.P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. (1999) Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99, 703-712
-
(1999)
Cell
, vol.99
, pp. 703-712
-
-
Debose-Boyd, R.A.1
Brown, M.S.2
Li, W.P.3
Nohturfft, A.4
Goldstein, J.L.5
Espenshade, P.J.6
-
27
-
-
0032185770
-
Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells
-
Sakai, J., Rawson, R.B., Espenshade, P.J., Cheng, D., Seegmiller, A.C., Goldstein, J.L., and Brown, M.S. (1998) Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol. Cell 2, 505-514
-
(1998)
Mol. Cell
, vol.2
, pp. 505-514
-
-
Sakai, J.1
Rawson, R.B.2
Espenshade, P.J.3
Cheng, D.4
Seegmiller, A.C.5
Goldstein, J.L.6
Brown, M.S.7
-
28
-
-
84857548618
-
Preventing phosphorylation of sterol regulatory elementbinding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity
-
Kotzka, J., Knebel, B., Haas, J., Kremer, L., Jacob, S., Hartwig, S., Nitzgen, U., and Muller-Wieland, D. (2012) Preventing phosphorylation of sterol regulatory elementbinding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity. PLoS One 7, e32609
-
(2012)
PLoS One
, vol.7
-
-
Kotzka, J.1
Knebel, B.2
Haas, J.3
Kremer, L.4
Jacob, S.5
Hartwig, S.6
Nitzgen, U.7
Muller-Wieland, D.8
-
29
-
-
0041731803
-
A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6
-
Okada, T., Haze, K., Nadanaka, S., Yoshida, H., Seidah, N.G., Hirano, Y., Sato, R., Negishi, M., and Mori, K. (2003) A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J. Biol. Chem. 278, 31024-31032
-
(2003)
J. Biol. Chem
, vol.278
, pp. 31024-31032
-
-
Okada, T.1
Haze, K.2
Nadanaka, S.3
Yoshida, H.4
Seidah, N.G.5
Hirano, Y.6
Sato, R.7
Negishi, M.8
Mori, K.9
-
30
-
-
0035873619
-
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
-
Matsuda, M., Korn, B.S., Hammer, R.E., Moon, Y.A., Komuro, R., Horton, J.D., Goldstein, J.L., Brown, M.S., and Shimomura, I. (2001) SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 15, 1206-1216
-
(2001)
Genes Dev
, vol.15
, pp. 1206-1216
-
-
Matsuda, M.1
Korn, B.S.2
Hammer, R.E.3
Moon, Y.A.4
Komuro, R.5
Horton, J.D.6
Goldstein, J.L.7
Brown, M.S.8
Shimomura, I.9
-
31
-
-
81055140116
-
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans
-
Walker, A.K., Jacobs, R.L., Watts, J.L., Rottiers, V., Jiang, K., Finnegan, D.M., Shioda, T., Hansen, M., Yang, F., Niebergall, L.J., Vance, D.E., Tzoneva, M., Hart, A.C., and Näär, A.M. (2011) A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147, 840-852
-
(2011)
Cell
, vol.147
, pp. 840-852
-
-
Walker, A.K.1
Jacobs, R.L.2
Watts, J.L.3
Rottiers, V.4
Jiang, K.5
Finnegan, D.M.6
Shioda, T.7
Hansen, M.8
Yang, F.9
Niebergall, L.J.10
Vance, D.E.11
Tzoneva, M.12
Hart, A.C.13
Näär, A.M.14
|