Urokinase-type plasminogen activator receptor (upar) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts

Journal of Biological Chemistry

Volumn 289, Issue 18, 2014, Pages 12791-12804

  Grove, Lisa M ^a   Southern, Brian D ^a   Jin, Tong H ^a   White, Kimberly E ^a   Paruchuri, Sailaja ^a   Harel, Efrat ^b   Wei, Ying ^c   Rahaman, Shaik O ^a   Gladson, Candece L ^d   Ding, Qiang ^a   Craik, Charles S ^b   Chapman, Harold A ^c   Olman, Mitchell A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE;

IDIOPATHIC PULMONARY FIBROSIS; INTEGRINS; LIPID RAFT; SIGNALING COMPLEX; THERAPEUTIC TARGETS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTORS (UPAR);

FIBROBLASTS;

CHOLESTEROL; FIBRONECTIN; FOCAL ADHESION KINASE; LIGAND; PEPTIDE; PROTEIN ANTIBODY; PROTEIN KINASE FYN; PROTEIN SHC; PROTEINASE; UROKINASE RECEPTOR; VERY LATE ACTIVATION ANTIGEN 5;

ACYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL MOTILITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND BINDING; LIPID RAFT; LUNG FIBROBLAST; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

FIBROBLAST; FIBROSIS; INTEGRIN; LIPID RAFT; UROKINASE RECEPTOR;

ANIMALS; BLOTTING, WESTERN; CAVEOLINS; CELL MOVEMENT; CELLS, CULTURED; FIBROBLASTS; FIBRONECTINS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INTEGRIN ALPHA5BETA1; MEMBRANE MICRODOMAINS; MICE; MICROSCOPY, FLUORESCENCE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; RNA INTERFERENCE; SEVERITY OF ILLNESS INDEX; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84899747366     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.498576     Document Type: Article

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