메뉴 건너뛰기




Volumn 316, Issue 9, 2010, Pages 1600-1609

Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts

Author keywords

FAK related non kinase; Fibroblast; Fibrosis; Focal adhesion kinase; Lung; Migration

Indexed keywords

CYTOPLASM PROTEIN; FOCAL ADHESION KINASE RELATED NON KINASE; RAC PROTEIN; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 77952763874     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.01.021     Document Type: Article
Times cited : (44)

References (33)
  • 2
    • 0041827155 scopus 로고    scopus 로고
    • Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10
    • White E.S., Thannickal V.J., Carskadon S.L., Markwart S., Toews G.B., Arenbert D.A. Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10. Am. J. Respir. Crit. Care Med. 2003, 168:436-442.
    • (2003) Am. J. Respir. Crit. Care Med. , vol.168 , pp. 436-442
    • White, E.S.1    Thannickal, V.J.2    Carskadon, S.L.3    Markwart, S.4    Toews, G.B.5    Arenbert, D.A.6
  • 3
    • 0037509990 scopus 로고    scopus 로고
    • Focal adhesion kinase: the first ten years
    • Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 2003, 116:1409-1416.
    • (2003) J. Cell Sci. , vol.116 , pp. 1409-1416
    • Parsons, J.T.1
  • 4
    • 0029979722 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase.
    • Chen H.C., Appeddu P.A., Isoda H., Guan J.L. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J. Biol. Chem. 1996, 271:26329-26334.
    • (1996) J. Biol. Chem. , vol.271 , pp. 26329-26334
    • Chen, H.C.1    Appeddu, P.A.2    Isoda, H.3    Guan, J.L.4
  • 5
    • 14844327984 scopus 로고    scopus 로고
    • P27(Kip1) and cyclin D1 are necessary for focal adhesion kinase (FAK) regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain
    • Ding Q., Grammer J.R., Nelson M.A., Guan J.L., Stewart J.E., Gladson C.L. p27(Kip1) and cyclin D1 are necessary for focal adhesion kinase (FAK) regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. J. Biol. Chem. 2005, 280:6802-6805.
    • (2005) J. Biol. Chem. , vol.280 , pp. 6802-6805
    • Ding, Q.1    Grammer, J.R.2    Nelson, M.A.3    Guan, J.L.4    Stewart, J.E.5    Gladson, C.L.6
  • 7
    • 0033002997 scopus 로고    scopus 로고
    • Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2
    • Owen J.D., Ruest P.J., Fry D.W., Hanks S.K. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol. Cell Biol. 1999, 19:4806-4818.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 4806-4818
    • Owen, J.D.1    Ruest, P.J.2    Fry, D.W.3    Hanks, S.K.4
  • 8
    • 0032820782 scopus 로고    scopus 로고
    • Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
    • Sieg D.J., Hauck C.R., Schlaepfer D.D. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J. Cell Sci. 1999, 112:2677-2691.
    • (1999) J. Cell Sci. , vol.112 , pp. 2677-2691
    • Sieg, D.J.1    Hauck, C.R.2    Schlaepfer, D.D.3
  • 9
    • 0030926774 scopus 로고    scopus 로고
    • Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
    • Schlaepfer D.D., Hunter T. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J. Biol. Chem. 1997, 272:13189-13195.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13189-13195
    • Schlaepfer, D.D.1    Hunter, T.2
  • 10
    • 0028877919 scopus 로고
    • Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
    • Calalb M.B., Polte T.R., Hanks S.K. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell Biol. 1995, 15:954-963.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 954-963
    • Calalb, M.B.1    Polte, T.R.2    Hanks, S.K.3
  • 11
    • 2542511549 scopus 로고    scopus 로고
    • Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
    • Hecker T.P., Ding Q., Rege T.A., Hanks S.K., Gladson C.L. Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene 2004, 23:3962-3971.
    • (2004) Oncogene , vol.23 , pp. 3962-3971
    • Hecker, T.P.1    Ding, Q.2    Rege, T.A.3    Hanks, S.K.4    Gladson, C.L.5
  • 12
    • 33748068089 scopus 로고    scopus 로고
    • New concepts regarding focal adhesion kinase promotion of cell migration and proliferation
    • Cox B.D., Natarajan M., Stettner M.R., Gladson C.L. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J. Cell Biochem. 2006, 99:35-52.
    • (2006) J. Cell Biochem. , vol.99 , pp. 35-52
    • Cox, B.D.1    Natarajan, M.2    Stettner, M.R.3    Gladson, C.L.4
  • 14
    • 0842281489 scopus 로고    scopus 로고
    • Multiple connections link FAK to cell motility and invasion
    • Schlaepfer D.D., Mitra S.K. Multiple connections link FAK to cell motility and invasion. Curr. Opin. Genet. Dev. 2004, 14:92-101.
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 92-101
    • Schlaepfer, D.D.1    Mitra, S.K.2
  • 15
    • 26444518835 scopus 로고    scopus 로고
    • FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: analysis of expression in transgenic mice
    • Hayasaka H., Simon K., Hershey E.D., Masumoto K.H., Parsons J.T. FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: analysis of expression in transgenic mice. J. Cell Biochem. 2005, 95:1248-1263.
    • (2005) J. Cell Biochem. , vol.95 , pp. 1248-1263
    • Hayasaka, H.1    Simon, K.2    Hershey, E.D.3    Masumoto, K.H.4    Parsons, J.T.5
  • 16
    • 0027439594 scopus 로고
    • Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK
    • Schaller M.D., Borgman C.A., Parsons J.T. Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Mol. Cell Biol. 1993, 13:785-791.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 785-791
    • Schaller, M.D.1    Borgman, C.A.2    Parsons, J.T.3
  • 17
    • 0035137373 scopus 로고    scopus 로고
    • Selective expression of an endogenous inhibitor of FAK regulated proliferation and migration of vascular smooth muscle cells
    • Taylor J.M., Mack C.P., Nolan K., Regan C.P., Owens G.K., Parsons J.T. Selective expression of an endogenous inhibitor of FAK regulated proliferation and migration of vascular smooth muscle cells. Mol. Cell Biol. 2001, 21:1565-1572.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 1565-1572
    • Taylor, J.M.1    Mack, C.P.2    Nolan, K.3    Regan, C.P.4    Owens, G.K.5    Parsons, J.T.6
  • 18
    • 0037011055 scopus 로고    scopus 로고
    • FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth
    • Hauck C.R., Hsia D.A., Puente X.S., Cheresh D.A., Schlaepfer D.D. FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J. 2002, 21:6289-6302.
    • (2002) EMBO J. , vol.21 , pp. 6289-6302
    • Hauck, C.R.1    Hsia, D.A.2    Puente, X.S.3    Cheresh, D.A.4    Schlaepfer, D.D.5
  • 19
    • 0029055784 scopus 로고
    • Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase
    • Hildebrand J.D., Schaller M.D., Parsons J.T. Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol. Cell Biol. 1995, 6:637-647.
    • (1995) Mol. Cell Biol. , vol.6 , pp. 637-647
    • Hildebrand, J.D.1    Schaller, M.D.2    Parsons, J.T.3
  • 20
    • 0033567905 scopus 로고    scopus 로고
    • Fibrin fragment induction of plasminogen activator inhibitor transcription is mediated by activator protein-1 through a highly conserved element
    • Olman M.A., Hagood J.S., Simmons W.L., Fuller G.M., Vinson C., White K.E. Fibrin fragment induction of plasminogen activator inhibitor transcription is mediated by activator protein-1 through a highly conserved element. Blood 1999, 94:2029-2038.
    • (1999) Blood , vol.94 , pp. 2029-2038
    • Olman, M.A.1    Hagood, J.S.2    Simmons, W.L.3    Fuller, G.M.4    Vinson, C.5    White, K.E.6
  • 21
    • 0029923239 scopus 로고    scopus 로고
    • Regulation of type I plasminogen activator inhibitor by fibrin degradation products in rat lung fibroblasts
    • Hagood J.S., Olman M.A., Zeballos J.G., White K.E., Fuller G.M. Regulation of type I plasminogen activator inhibitor by fibrin degradation products in rat lung fibroblasts. Blood 1996, 87:3749.
    • (1996) Blood , vol.87 , pp. 3749
    • Hagood, J.S.1    Olman, M.A.2    Zeballos, J.G.3    White, K.E.4    Fuller, G.M.5
  • 22
    • 0141994778 scopus 로고    scopus 로고
    • The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged
    • Ding Q., Stewart J.E., Olman M.A., Klobe M.R., Gladson C.L. The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged. J. Biol. Chem. 2003, 278:39882-39891.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39882-39891
    • Ding, Q.1    Stewart, J.E.2    Olman, M.A.3    Klobe, M.R.4    Gladson, C.L.5
  • 23
    • 0037105704 scopus 로고    scopus 로고
    • Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin
    • Ding Q., Stewart J.E., Prince C.W., Chang P.L., Trikha M., Han X., Grammer J.R., Gladson C.L. Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin. Cancer Res. 2002, 62:533643.
    • (2002) Cancer Res. , vol.62 , pp. 533643
    • Ding, Q.1    Stewart, J.E.2    Prince, C.W.3    Chang, P.L.4    Trikha, M.5    Han, X.6    Grammer, J.R.7    Gladson, C.L.8
  • 24
    • 67650069963 scopus 로고    scopus 로고
    • Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins
    • Zhu S., Gladson C.L., White K.E., Ding Q., Stewart J., Jin T.H., Chapman H.A., Olman M.A. Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins. Am. J. Physiol Lung Cell Mol. Physiol. 2009, 297:L97-L108.
    • (2009) Am. J. Physiol Lung Cell Mol. Physiol. , vol.297
    • Zhu, S.1    Gladson, C.L.2    White, K.E.3    Ding, Q.4    Stewart, J.5    Jin, T.H.6    Chapman, H.A.7    Olman, M.A.8
  • 25
    • 0037501115 scopus 로고    scopus 로고
    • Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells
    • Haskell H., Natarajan M., Hecker T.P., Ding Q., Stewart J.E., Grammer J.R., Gladson C.L. Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells. Clin. Cancer Res. 2003, 9:2157-2165.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2157-2165
    • Haskell, H.1    Natarajan, M.2    Hecker, T.P.3    Ding, Q.4    Stewart, J.E.5    Grammer, J.R.6    Gladson, C.L.7
  • 26
    • 55249089456 scopus 로고    scopus 로고
    • FAK-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner
    • Ding Q., Gladson C.L., Wu H., Hayasaka H., Olman M.A. FAK-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner. J. Biol. Chem. 2008, 283:26839-26849.
    • (2008) J. Biol. Chem. , vol.283 , pp. 26839-26849
    • Ding, Q.1    Gladson, C.L.2    Wu, H.3    Hayasaka, H.4    Olman, M.A.5
  • 27
    • 0029955660 scopus 로고    scopus 로고
    • An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase
    • Hildebrand J.D., Taylor J.M., Parsons J.T. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol. Cell Biol. 1996, 16:3169-3178.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 3169-3178
    • Hildebrand, J.D.1    Taylor, J.M.2    Parsons, J.T.3
  • 30
    • 85047694529 scopus 로고    scopus 로고
    • Disorders of lung matrix remodeling
    • Chapman H.A. Disorders of lung matrix remodeling. J. Clin. Invest. 2004, 113:148-157.
    • (2004) J. Clin. Invest. , vol.113 , pp. 148-157
    • Chapman, H.A.1
  • 31
    • 85059711788 scopus 로고    scopus 로고
    • Mechanisms of fibroproliferation in acute lung injury
    • Maracel Dekker, Inc., New York, M.A. Matthay, C. Lenfant (Eds.)
    • Olman M.A. Mechanisms of fibroproliferation in acute lung injury. "Acute Respiratory Distress Syndrome" 2003, Maracel Dekker, Inc., New York. M.A. Matthay, C. Lenfant (Eds.).
    • (2003) "Acute Respiratory Distress Syndrome"
    • Olman, M.A.1
  • 33
    • 0032784060 scopus 로고    scopus 로고
    • Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase
    • Nolan K., Lacoste J., Parsons J.T. Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Mol. Cell Biol. 1999, 19:6120-6129.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 6120-6129
    • Nolan, K.1    Lacoste, J.2    Parsons, J.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.