Disruption of the talin gene arrests mouse development at the gastrulation stage

Developmental Dynamics

Volumn 219, Issue 4, 2000, Pages 560-574

  Monkley, Susan J ^a   Zhou, Xiao Hong ^b   Kinston, Sarah J ^a   Giblett, Susan M ^a   Hemmings, Lance ^a   Priddle, Helen ^a   Brown, Jane E ^a   Pritchard, Catrin A ^a   Critchley, David R ^a   Fässler, Reinhard ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Focal adhesions; Gastrulation; Gene targeting; Integrins; Talin

Indexed keywords

CYTOSKELETON PROTEIN; FIBRONECTIN; LAMININ; TALIN;

ANIMAL CELL; ARTICLE; BLASTOCYST; CELL CULTURE; CELL MIGRATION; CELL SPREADING; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EXTRACELLULAR MATRIX; GASTRULATION; GENE DISRUPTION; GENE TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; TROPHOBLAST;

ANIMALS; APOPTOSIS; BLASTOCYST; CELL ADHESION; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHIMERA; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL PROTEINS; FIBRONECTINS; GASTRULA; GENE EXPRESSION; GENE TARGETING; HEPARAN SULFATE PROTEOGLYCANS; IN SITU NICK-END LABELING; LAMININ; MICE; MICE, KNOCKOUT; PREGNANCY; RNA, UNTRANSLATED; STEM CELLS; T-BOX DOMAIN PROTEINS; TALIN; TROPHOBLASTS;

ANIMALIA; VERTEBRATA;

EID: 0033667594     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1079>3.0.CO;2-Y     Document Type: Article

References (53)

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5. Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix
6. Talin concentrates to the midbody region during mammalian cell cytokinesis
7. Monoclonal antibodies recognizing the N- and C- Terminal regions of talin disrupt actin stress fibers when micro-injected into human fibroblasts
8. Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
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12. A new protein of adhesion plaques and ruffling membranes
13. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation
14. RhoA activity is required for fibronectin assembly and counteracts β1B integrin inhibitory effect in FRT epithelial cells
15. Murine wnt-11 and wnt-12 have temporally and spatially restricted expression patterns during embryonic development
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21. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
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23. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo
24. Endothelial cells interact with the core protein of basement membrane perlecan through β1 and β3 integrins: An adhesion modulated by glycosaminoglycan
25. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site
26. Characterisation of two F-actin-binding and oligomerisation sites in the cell-contact protein vinculin
27. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
28. Peptide-specific antibodies localise the major lipid binding sites of talin dimers to oppositely arranged N-terminal 47 kDa subdomains
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35. The I/LWEQ module: A conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals
36. Three-dimensional segregtion of supramolecular activation clusters in T cells
37. Talin null cells of Dictyostelium discoideum are strongly defective in adhesion to particle and substrate surfaces and slightly impaired in cytokinesis
38. Microinjection of antibodies against talin inhibits the spreading and migration of fibroblasts
39. An interaction between α-actinin and the β1 integrin subunit in vitro
40. Integrin β cytoplasmic domains differentially bind to cytoskeletal proteins
41. Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated ES cells
42. Sequence and domain-structure of talin
43. Phospholipid binding of synthetic talin peptides provides evidence for an intrinsic membrane anchor of talin
44. Expression of IGF-II and H19 mRNA in the neonatal rat during normal maturation and after dexamethasone administration
45. Deletion of β1 integrins in mice results in inner cell mass failure and peri-implantation lethality
46. Dissection of the function of the focal adhesion protein paxillin, in vivo and in integrin signalling
47. A unique talin homologue with a villin headpiece-like domain is required for multicellular morphogenesis in Dictyostelium
48. Expression of the cell surface-associated glycoprotein, fibronectin, in the early mouse embryo
49. The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation
50. Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains
51. Vinculin knockout results in heart and brain defects during embryonic development