GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides

eLife

Volumn 2014, Issue 3, 2014, Pages

  Zhang, Yu ^a,b   Degen, David ^a,b   Ho, Mary X ^b   Sineva, Elena ^a,b   Ebright, Katherine Y ^a,b   Ebright, Yon W ^a,b   Mekler, Vladimir ^a,b   Vahedian Movahed, Hanif ^a,b   Feng, Yu ^a,b   Yin, Ruiheng ^a,b   Tuske, Steve ^b   Irschik, Herbert ^c   Jansen, Rolf ^c   Maffioli, Sonia ^d   Donadio, Stefano ^d   Arnold, Eddy ^b   Ebright, Richard H ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d NAICONS Srl   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYCLIC PEPTIDE ANTIBIOTIC GE23077; RIFAMYCIN; RNA POLYMERASE; SORANGICIN; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; CYCLOPEPTIDE; DNA DIRECTED RNA POLYMERASE; GE 23077-A; GE 23077-B; NUCLEOTIDE; SORANGICIN A; SORANGICIN B;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CHROMOSOME; CHROMOSOME; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GENETIC COMPLEMENTATION; MUTAGENESIS; NONHUMAN; NUCLEOTIDE BINDING SITE; POLYMERASE CHAIN REACTION; STEREOCHEMISTRY; TRANSCRIPTION ELONGATION; TRANSCRIPTION INITIATION; BINDING SITE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSCRIPTION; METABOLISM; MOLECULAR MODEL; THERMUS THERMOPHILUS; X RAY CRYSTALLOGRAPHY;

AMINOGLYCOSIDES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MODELS, MOLECULAR; NUCLEOTIDES; PEPTIDES, CYCLIC; RIFAMYCINS; RNA POLYMERASE I; THERMUS THERMOPHILUS; TRANSCRIPTION, GENETIC;

EID: 84899653185     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02450     Document Type: Article

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