Rifamycins do not function by allosteric modulation of binding of Mg 2+ to the RNA polymerase active center

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 39, 2008, Pages 14820-14825

  Feklistov, Andrey ^a,b   Mekler, Vladimir ^c   Jiang, Qiaorong ^c   Westblade, Lars F ^a   Irschik, Herbert ^d   Jansen, Rolf ^d   Mustaev, Arkady ^b   Darst, Seth A ^a   Ebright, Richard H ^c  

^a ROCKEFELLER UNIVERSITY   (United States)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Antibacterial agents; Rifabutin; Rifampicin; Rifapentine; RNA polymerase inhibitors

Indexed keywords

MAGNESIUM; RIFABUTIN; RIFAMYCIN; RIFAPENTINE; RNA POLYMERASE; ANTIINFECTIVE AGENT; DNA DIRECTED RNA POLYMERASE;

ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; ALLOSTERISM; BINDING SITE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MUTATION;

BACTERIA (MICROORGANISMS);

ALLOSTERIC REGULATION; ANTI-BACTERIAL AGENTS; BINDING SITES; DNA-DIRECTED RNA POLYMERASES; MAGNESIUM; MUTATION; RIFAMYCINS;

EID: 54449091987     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802822105     Document Type: Article

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