Structural characterization of P1′-diversified urea-based inhibitors of glutamate carboxypeptidase II

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 10, 2014, Pages 2340-2345

  Pavlicek, Jiri ^a   Ptacek, Jakub ^a   Cerny, Jiri ^a   Byun, Youngjoo ^b,c   Skultetyova, Lubica ^a   Pomper, Martin G ^b   Lubkowski, Jacek ^d   Barinka, Cyril ^a  

^a INSTITUTE OF BIOTECHNOLOGY   (Czech Republic)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Korea University   (South Korea)

^d FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

GCPII; Metallopeptidase; Prostate specific membrane antigen; PSMA; Structure based drug design; Urea based inhibitor; X ray crystallography

Indexed keywords

GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; GLUTAMIC ACID; ENZYME INHIBITOR; GLUTAMATE CARBOXYPEPTIDASE II, HUMAN; MEMBRANE ANTIGEN; UREA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTALLIZATION; DRUG STRUCTURE; HYDROPHOBICITY; MOLECULAR INTERACTION; PHYSICAL CHEMISTRY; QUANTUM MECHANICS; STRUCTURE ANALYSIS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG DESIGN; HUMAN; KINETICS; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTIGENS, SURFACE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84899649997     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.066     Document Type: Article

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