Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI

Brain Research

Volumn 1395, Issue , 2011, Pages 62-73

  Feng, Jun Feng ^a,e   Van, Ken C ^a   Gurkoff, Gene G ^a   Kopriva, Christina ^a   Olszewski, Rafal T ^b   Song, Minsoo ^c   Sun, Shifeng ^d   Xu, Man ^d   Neale, Joseph H ^b   Yuen, Po Wai ^c   Lowe, David A ^c   Zhou, Jia ^c   Lyeth, Bruce G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c PSYCHOGENICS INC   (United States)

^d PHARMARON   (United States)

^e SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Glutamate; Hippocampus; Morris water maze; N acetylaspartylglutamate (NAAG); Traumatic brain injury (TBI)

Indexed keywords

ENZYME INHIBITOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; PEPTIDASE; PGI 02749; PGI 02776; UNCLASSIFIED DRUG; ZJ 43;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY CONSOLIDATION; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; GLUTAMATE CARBOXYPEPTIDASE II; MALE; MICE; MICE, INBRED C57BL; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; NEUROTRANSMITTER AGENTS; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; UREA;

ANIMALIA; RATTUS; VERTEBRATA;

EID: 79957926348     PISSN: 00068993     EISSN: 00068993     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.04.022     Document Type: Article

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