Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding

European Journal of Biochemistry

Volumn 271, Issue 13, 2004, Pages 2782-2790

  Bařinka, Cyril ^a   Mlčochová, Petra ^a,b   Šacha, Payel ^a,b   Hilgert, Ivan ^c   Majer, Pavel ^d   Slusher, Barbara S ^d   Hořejší, Václav ^c   Konvalinka, Jan ^a,b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^d GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Metallopeptidase; Mutagenesis; NAALADase; Prostate cancer; PSMA

Indexed keywords

AMINO ACID; CARBOXYPEPTIDASE; GAMMA GLUTAMYL HYDROLASE; GLUTAMATE CARBOXYPEPTIDASE II; ISOENZYME; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; GENETIC TRANSFECTION; HYDROLYSIS; MOLECULAR CLONING; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

AMINO ACIDS; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CATALYSIS; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; PROTEIN FOLDING;

ANIMALIA; STREPTOMYCES; STREPTOMYCES GRISEUS; VIBRIO; VIBRIO PROTEOLYTICUS;

EID: 3042849118     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04209.x     Document Type: Article

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