Polymer brush coatings regulating cell behavior: Passive interfaces turn into active

Acta Biomaterialia

Volumn 10, Issue 6, 2014, Pages 2367-2378

  Moroni, Lorenzo ^a,d   Klein Gunnewiek, Michel ^b   Benetti, Edmondo M ^b,c  

^a UNIVERSITY OF TWENTE   (Netherlands)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c ETH ZURICH   (Switzerland)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Biointerfaces; Biomaterials; Cells; Polymer brush; Surface initiated polymerization

Indexed keywords

CELLS; CYTOLOGY; GRAFTING (CHEMICAL); INTERFACES (MATERIALS); PLASTIC COATINGS; SURFACE TREATMENT;

ACTIVE COMPONENTS; BIO-CHEMICALS; BIOINTERFACES; CELL BEHAVIOURS; MATERIALS TECHNOLOGY; PASSIVE INTERFACES; POLYMER BRUSHES; SURFACE INITIATED POLYMERIZATION; SURFACE-MODIFICATION; TECHNOLOGY PLATFORMS;

DENDRIMERS;

POLY(N ISOPROPYLACRYLAMIDE); POLYMER; BIOMATERIAL;

ACTIVE TRANSPORT; CELL ADHESION; CELL CYCLE REGULATION; CELL ENGINEERING; CELL FUNCTION; CELL MANIPULATION; HEAT SENSITIVITY; NANOTECHNOLOGY; PASSIVE TRANSPORT; POLYMER BRUSH; POLYMERIZATION; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; STEM CELL; SURFACE PROPERTY; ANIMAL; CHEMISTRY; HUMAN; TISSUE SCAFFOLD;

ANIMALS; BIOCOMPATIBLE MATERIALS; HUMANS; POLYMERS; TISSUE SCAFFOLDS;

EID: 84899639937     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.02.048     Document Type: Review

References (121)

1. Hidalgo-Bastida LA, Cartmell SH. Mesenchymal stem cells, osteoblasts and extracellular matrix proteins: enhancing cell adhesion and differentiation for bone tissue engineering. Tissue Eng B 2010;16:405-12.
2. von der Mark K, Park J, Bauer S, Schmuki P. Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix. Cell Tissue Res 2010;339:131-53.
3. Langer R, Vacanti JP. Tissue Engineering. Science 1993;260:920-6.
4. Vacanti CA. History of tissue engineering and a glimpse into its future. Tissue Eng 2006;12:1137-42.
5. Amass W, Amass A, Tighe B. A review of biodegradable polymers: uses, current developments in the synthesis and characterization of biodegradable polyesters, blends of biodegradable polymers and recent advances in biodegradation studies. Polym Int 1998;47:89-144.
6. Fioretta ES, Fledderus JO, Burakowska-Meise EA, Baaijens FPT, Verhaar MC, Bouten CVC. Polymer-based scaffold designs for in situ vascular tissue engineering: controlling recruitment and differentiation behavior of endothelial colony forming cells. Macromol Biosci 2012;12:577-90.
7. Ravichandran R, Sundarrajan S, Venugopal JR, Mukherjee S, Ramakrishna S. Advances in polymeric systems for tissue engineering and biomedical applications. Macromol Biosci 2012;12:286-311.
8. Shin H, Jo S, Mikos AG. Biomimetic materials for tissue engineering. Biomaterials 2003;24:4353-64.
9. Chen R, Hunt JA. Biomimetic materials processing for tissue-engineering processes. J Mater Chem 2007;17:3974-9.
10. Senaratne W, Andruzzi L, Ober CK. Self-assembled monolayers and polymer brushes in biotechnology: current applications and future perspectives. Biomacromolecules 2005;6:2427-48.
11. Raynor JE, Capadona JR, Collard DM, Petrie TA, Garcia AJ. Polymer brushes and self-assembled monolayers: versatile platforms to control cell adhesion to biomaterials. Biointerphases 2009;4:Fa3-Fa16.
12. Edmondson S, Osborne VL, Huck WTS. Polymer brushes via surface-initiated polymerizations. Chem Soc Rev 2004;33:14-22.
13. Zhao B, Brittain WJ. Polymer brushes: surface-immobilized macromolecules. Prog Polym Sci 2000;25:677-710.
14. Milner ST. Polymer brushes. Science 1991;251:905-14.
15. Husseman M, Malmstrom EE, McNamara M, Mate M, Mecerreyes D, Benoit DG, et al. Controlled synthesis of polymer brushes by "living" free radical polymerization techniques. Macromolecules 1999;32:1424-31.
16. Zdyrko B, Luzinov I. Polymer brushes by the "grafting to" method. Macromol Rapid Commun 2011;32:859-69.
17. Pasetto P, Blas H, Audouin F, Boissiere C, Sanchez C, Save M, et al. Mechanistic insight into surface-initiated polymerization of methyl methacrylate and styrene via ATRP from ordered mesoporous silica particles. Macromolecules 2009;42:5983-95.
18. Kruk M, Dufour B, Celer EB, Kowalewski T, Jaroniec M, Matyjaszewski K. Grafting monodisperse polymer chains from concave surfaces of ordered mesoporous silicas. Macromolecules 2008;41:8584-91.
19. Xiang P, Petrie K, Kontopoulou M, Ye ZB, Subramanian R. Tuning structural parameters of polyethylene brushes on silica nanoparticles in surfaceinitiated ethylene "living" polymerization and effects on silica dispersion in a polyolefin matrix. Polym Chem-UK 2013;4:1381-95.
20. Koylu D, Carter KR. Stimuli-responsive surfaces utilizing cleavable polymer brush layers. Macromolecules 2009;42:8655-60.
21. Benetti EM, Zapotoczny S, Vancso J. Tunable thermoresponsive polymeric platforms on gold by "photoiniferter"-based surface grafting. Adv Mater 2007;19:268-71.
22. Kang C, Crockett R, Spencer ND. Molecular-weight determination of polymer brushes generated by SI-ATRP on flat surfaces. Macromolecules 2014;47: 269-75.
23. Matyjaszewski K, Xia JH. Atom transfer radical polymerization. Chem Rev 2001;101:2921-90.
24. Siegwart DJ, Oh JK, Matyjaszewski K. ATRP in the design of functional materials for biomedical applications. Prog Polym Sci 2012;37:18-37.
25. Otsu T. Iniferter concept and living radical polymerization. J Polym Sci A 2000;38:2121-36.
26. Chiefari J, Chong YK, Ercole F, Krstina J, Jeffery J, Le TPT, et al. Living freeradical polymerization by reversible addition-fragmentation chain transfer: the RAFT process. Macromolecules 1998;31:5559-62.
27. Mansky P, Liu Y, Huang E, Russell TP, Hawker CJ. Controlling polymersurface interactions with random copolymer brushes. Science 1997;275: 1458-60.
28. Kim JB, Huang WX, Bruening ML, Baker GL. Synthesis of triblock copolymer brushes by surface-initiated atom transfer radical polymerization. Macromolecules 2002;35:5410-6.
29. Boyes SG, Akgun B, Brittain WJ, Foster MD. Synthesis, characterization, and properties of polyelectrolyte block copolymer brushes prepared by atom transfer radical polymerization and their use in the synthesis of metal nanoparticles. Macromolecules 2003;36:9539-48.
30. Brittain WJ, Boyes SG, Granville AM, Baum M, Mirous BK, Akgun B, et al. Surface rearrangement of diblock copolymer brushes - stimuli responsive films. Adv Polym Sci 2006;198:125-47.
31. Wang X, Xiao X, Wang XH, Zhou JJ, Li L, Xu J. Reversibly switchable doubleresponsive block copolymer brushes. Macromol Rapid Commun 2007;28: 828-33.
32. Rowe MA, Hammer BAG, Boyes SG. Synthesis of surface-initiated stimuliresponsive diblock copolymer brushes utilizing a combination of ATRP and RAFT polymerization techniques. Macromolecules 2008;41:4147-57.
33. Ignatova M, Voccia S, Gabriel S, Gilbert B, Cossement D, Jerome R, et al. Stainless steel grafting of hyperbranched polymer brushes with an antibacterial activity: synthesis, characterization, and properties. Langmuir 2009;25:891-902.
34. Banerjee I, Pangule RC, Kane RS. Antifouling coatings: recent developments in the design of surfaces that prevent fouling by proteins, bacteria, and marine organisms. Adv Mater 2011;23:690-718.
35. Advincula RC, Brittain WJ, Caster KC, Ruhe J. Polymer Brushes: Synthesis, Characterization. Applications. Weinheim: Wiley-VCH; 2004.
36. Gillich T, Benetti EM, Rakhmatullina E, Konradi R, Li W, Zhang A, et al. Selfassembly of focal point oligo-catechol ethylene glycol dendrons on titanium oxide surfaces: adsorption kinetics, surface characterization, and nonfouling properties. J Am Chem Soc 2011;133:10940-50.
37. Duan HW, Nie SM. Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings. J Am Chem Soc 2007;129: 3333-8.
38. Gudipati CS, Finlay JA, Callow JA, Callow ME, Wooley KL. The antifouling and fouling-release perfomance of hyperbranched fluoropolymer (HBFP)- poly(ethylene glycol) (PEG) composite coatings evaluated by adsorption of biomacromolecules and the green fouling alga Ulva. Langmuir 2005;21: 3044-53.
39. Ma HW, Hyun JH, Stiller P, Chilkoti A. "Non-fouling" oligo(ethylene glycol)- functionalized polymer brushes synthesized by surface-initiated atom transfer radical polymerization. Adv Mater 2004;16:338-41.
40. Brown AA, Khan NS, Steinbock L, Huck WTS. Synthesis of oligo(ethylene glycol) methacrylate polymer brushes. Eur Polym J 2005;41:1757-65.
41. Tugulu S, Silacci P, Stergiopulos N, Klok HA. RGD-functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells. Biomaterials 2007;28:2536-46.
42. Tugulu S, Klok HA. Stability and nonfouling properties of poly(poly (ethylene glycol) methacrylate) brushes under cell culture conditions. Biomacromolecules 2008;9:906-12.
43. Raynor JE, Petrie TA, Garcia AJ, Collard DM. Controlling cell adhesion to titanium: functionalization of poly[oligo(ethylene glycol)methacrylate] brushes with cell-adhesive peptides. Adv Mater 2007;19:1724-8.
44. Singh N, Husson SM, Cui XF, Boland T. Polymer brush layers with variation of grafting density for peptide adsorption and cell adhesion studies. Abstr Pap Am Chem S 2006:231.
45. Singh N, Cui XF, Boland T, Husson SM. The role of independently variable grafting density and layer thickness of polymer nanolayers on peptide adsorption and cell adhesion. Biomaterials 2007;28:763-71.
46. Klein Gunnewiek M, Benetti EM, Di Luca A, van Blitterswijk CA, Moroni L, Vancso GJ. Thin polymer brush decouples biomaterial's micro-nanotopology and stem cell adhesion. Langmuir 2013;29:13843-52.
47. Andruzzi L, Senaratne W, Hexemer A, Sheets ED, Ilic B, Kramer EJ, et al. Oligo(ethylene glycol) containing polymer brushes as bioselective surfaces. Langmuir 2005;21:2495-504.
48. Tria MCR, Grande CDT, Ponnapati RR, Advincula RC. Electrochemical deposition and surface-initiated RAFT polymerization: protein and cell-resistant PPEGMEMA polymer brushes. Biomacromolecules 2010;11:3422-31.
49. Ren XS, Wu YZ, Cheng Y, Ma HW, Wei SC. Fibronectin and bone morphogeneticprotein- 2-decorated poly(OEGMA-r-HEMA) brushes promote osseointegration of titanium surfaces. Langmuir 2011;27:12069-73.
50. Wischerhoff E, Uhlig K, Lankenau A, Borner HG, Laschewsky A, Duschl C, et al. Controlled cell adhesion on PEG-based switchable surfaces. Angew Chem Int Ed 2008;47:5666-8.
51. Lutz JF, Hoth A. Preparation of ideal PEG analogues with a tunable thermosensitivity by controlled radical copolymerization of 2-(2-methoxyethoxy) ethyl methacrylate and oligo(ethylene glycol) methacrylate. Macromolecules 2006;39:893-6.
52. Lutz JF, Weichenhan K, Akdemir O, Hoth A. About the phase transitions in aqueous solutions of thermoresponsive copolymers and hydrogels based on 2-(2-methoxyethoxy)ethyl methacrylate and oligo(ethylene glycol) methacrylate. Macromolecules 2007;40:2503-8.
53. Uhlig K, Wischerhoff E, Lutz JF, Laschewsky A, Jaeger MS, Lankenau A, et al. Monitoring cell detachment on PEG-based thermoresponsive surfaces using TIRF microscopy. Soft Matter 2010;6:4262-7.
54. Dworak A, Utrata-Wesolek A, Szweda D, Kowalczuk A, Trzebicka B, Aniol J, et al. Poly[tri(ethylene glycol) ethyl ether methacrylate]-coated surfaces for controlled fibroblasts culturing. ACS Appl Mater Inter 2013;5:2197-207.
55. Hoogenboom R. Poly(2-oxazoline)s: a polymer class with numerous potential applications. Angew Chem Int Ed 2009;48:7978-94.
56. Tong J, Zimmerman MC, Li SM, Yi X, Luxenhofer R, Jordan R, et al. Neuronal uptake and intracellular superoxide scavenging of a fullerene (C-60)-poly(2- oxazoline)s nanoformulation. Biomaterials 2011;32:3654-65.
57. Tong J, Yi X, Luxenhofer R, Banks WA, Jordan R, Zimmerman MC, et al. Conjugates of superoxide dismutase 1 with amphiphilic poly(2-oxazoline) block copolymers for enhanced brain delivery: synthesis, characterization and evaluation in vitro and in vivo. Mol Pharm 2013;10:360-77.
58. Luxenhofer R, Han YC, Schulz A, Tong J, He ZJ, Kabanov AV, et al. Poly(2- oxazoline)s as polymer therapeutics. Macromol Rapid Commun 2012;33:1613-31.
59. Viegas TX, Bentley MD, Harris JM, Fang ZF, Yoon K, Dizman B, et al. Polyoxazoline: chemistry, properties, and applications in drug delivery. Bioconjugate Chem 2011;22:976-86.
60. Mero A, Fang ZH, Pasut G, Veronese FM, Viegas TX. Selective conjugation of poly(2-ethyl 2-oxazoline) to granulocyte colony stimulating factor. J Control Release 2012;159:353-61.
61. Konradi R, Pidhatika B, Muhlebach A, Textort M. Poly 2-methyl-2- oxazoline: a peptide-like polymer for protein-repellent surfaces. Langmuir 2008;24: 613-6.
62. Pidhatika B, Moller J, Benetti EM, Konradi R, Rakhmatullina E, Muhlebach A, et al. The role of the interplay between polymer architecture and bacterial surface properties on the microbial adhesion to polyoxazoline-based ultrathin films. Biomaterials 2010;31:9462-72.
63. Konradi R, Acikgoz C, Textor M. Polyoxazolines for nonfouling surface coatings - a direct comparison to the gold standard PEG. Macromol Rapid Commun 2012;33:1663-76.
64. Pidhatika B, Rodenstein M, Chen Y, Rakhmatullina E, Muhlebach A, Acikgoz C, et al. Comparative stability studies of poly(2-methyl-2-oxazoline) and poly(ethylene glycol) brush coatings. Biointerphases 2012:7.
65. Hutter NA, Reitinger A, Garrido JA, Jordan R. Biofunctionalization of patterned poly(2-oxazoline) bottle-brush-brushes on diamond. Abstr Pap Am Chem S 2012:243.
66. Zhang N, Pompe T, Amin I, Luxenhofer R, Werner C, Jordan R. Tailored poly(2- oxazoline) polymer brushes to control protein adsorption and cell adhesion. Macromol Biosci 2012;12:926-36.
67. Zhang N, Pompe T, Luxenhofer R, Werner C, Jordan R. Poly(2-oxazoline) bottle-brush brushes for the control of protein adsoption and cell adhesion. Abstr Pap Am Chem S 2012:243.
68. Chiang EN, Dong R, Ober CK, Baird BA. Cellular responses to patterned poly(acrylic acid) brushes. Langmuir 2011;27:7016-23.
69. Navarro M, Benetti EM, Zapotoczny S, Planell JA, Vancso GJ. Buried, covalently attached RGD peptide motifs in poly(methacrylic acid) brush layers: the effect of brush structure on cell adhesion. Langmuir 2008;24:10996-1002.
70. Yuan SJ, Xiong G, Wang XY, Zhang S, Choong C. Surface modification of polycaprolactone substrates using collagen-conjugated poly(methacrylic acid) brushes for the regulation of cell proliferation and endothelialisation. J Mater Chem 2012;22:13039-49.
71. Yuan SJ, Xiong G, Roguin A, Choong C. Immobilization of gelatin onto poly(glycidyl methacrylate)-grafted polycaprolactone substrates for improved cell-material interactions. Biointerphases 2012:7.
72. Ren TC, Mao ZW, Guo J, Gao CY. Directional migration of vascular smooth muscle cells guided by a molecule weight gradient of poly(2-hydroxyethyl methacrylate) brushes. Langmuir 2013;29:6386-95.
73. Liu HL, Li YY, Sun K, Fan JB, Zhang PC, Meng JX, et al. Dual-responsive surfaces modified with phenylboronic acid-containing polymer brush to reversibly capture and release cancer cells. J Am Chem Soc 2013;135:7603-9.
74. Ivanov AE, Eccles J, Panahi HA, Kumar A, Kuzimenkova MV, Nilsson L, et al. Boronate-containing polymer brushes: characterization, interaction with saccharides and mammalian cancer cells. J Biomed Mater Res A 2009;88A:213-25.
75. Ivanov AE, Kumar A, Nilsang S, Aguilar MR, Mikhalovska LI, Savina IN, et al. Evaluation of boronate-containing polymer brushes and gels as substrates for carbohydrate-mediated adhesion and cultivation of animal cells. Colloid Surf B 2010;75:510-9.
76. Sun TL, Han D, Rhemann K, Chi LF, Fuchs H. Stereospecific interaction between immune cells and chiral surfaces. J Am Chem Soc 2007;129:1496.
77. Wang X, Gan H, Sun TL, Su BL, Fuchs H, Vestweber D, et al. Stereochemistry triggered differential cell behaviours on chiral polymer surfaces. Soft Matter 2010;6:3851-5.
78. Petrie TA, Raynor JE, Reyes CD, Burns KL, Collard DM, Garcia AJ. The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration. Biomaterials 2008;29:2849-57.
79. Paripovic D, Hall-Bozic H, Klok HA. Osteoconductive surfaces generated from peptide functionalized poly(2-hydroxyethyl methacrylate-co-2- (methacryloyloxy)ethyl phosphate) brushes. J Mater Chem 2012;22: 19570-8.
80. Yim H, Kent MS, Mendez S, Balamurugan SS, Balamurugan S, Lopez GP, et al. Temperature-dependent conformational change of PNIPAM grafted chains at high surface density in water. Macromolecules 2004;37:1994-7.
81. Plunkett KN, Zhu X, Moore JS, Leckband DE. PNIPAM chain collapse depends on the molecular weight and grafting density. Langmuir 2006;22:4259-66.
82. Jones DM, Smith JR, Huck WTS, Alexander C. Variable adhesion of micropatterned thermoresponsive polymer brushes: AFM investigations of poly (N-isopropylacrylamide) brushes prepared by surface-initiated polymerizations. Adv Mater 2002;14:1130-4.
83. Kaholek M, Lee WK, Ahn SJ, Ma HW, Caster KC, LaMattina B, et al. Stimulusresponsive poly(N-isopropylacrylamide) brushes and nanopatterns prepared by surface-initiated polymerization. Chem Mater 2004;16:3688-96.
84. Canavan HE, Cheng XH, Graham DJ, Ratner BD, Castner DG. Surface characterization of the extracellular matrix remaining after cell detachment from a thermoresponsive polymer. Langmuir 2005;21:1949-55.
85. Ista LK, Mendez S, Perez-Luna VH, Lopez GP. Synthesis of poly(Nisopropylacrylamide) on initiator-modified self-assembled monolayers. Langmuir 2001;17:2552-5.
86. Cho EC, Kim YD, Cho K. Thermally responsive poly (N-isopropylacrylamide) monolayer on gold: synthesis, surface characterization, and protein interaction/adsorption studies. Polymer 2004;45:3195-204.
87. Magoshi T, Ziani-Cherif H, Ohya S, Nakayama Y, Matsuda T. Thermoresponsive heparin coating: heparin conjugated with poly(Nisopropylacrylamide) at one terminus. Langmuir 2002;18:4862-72.
88. Xue CY, Yonet-Tanyeri N, Brouette N, Sferrazza M, Braun PV, Leckband DE. Protein adsorption on poly(N-isopropylacrylamide) brushes: dependence on grafting density and chain collapse. Langmuir 2011;27:8810-8.
89. Alarcon CDH, Farhan T, Osborne VL, Huck WTS, Alexander C. Bioadhesion at micro-patterned stimuli-responsive polymer brushes. J Mater Chem 2005;15:2089-94.
90. Yang J, Yamato M, Kohno C, Nishimoto A, Sekine H, Fukai F, et al. Cell sheet engineering: recreating tissues without biodegradable scaffolds. Biomaterials 2005;26:6415-22.
91. Takahashi H, Nakayama M, Yamato M, Okano T. Controlled chain length and graft density of thermoresponsive polymer brushes for optimizing cell sheet harvest. Biomacromolecules 2010;11:1991-9.
92. Takahashi H, Nakayama M, Itoga K, Yamato M, Okano T. Micropatterned thermoresponsive polymer brush surfaces for fabricating cell sheets with well-controlled orientational structures. Biomacromolecules 2011;12: 1414-8.
93. Nagase K, Watanabe M, Kikuchi A, Yamato M, Okano T. Thermo-responsive polymer brushes as intelligent biointerfaces: preparation via ATRP and characterization. Macromol Biosci 2011;11:400-9.
94. Tamura A, Nishi M, Kobayashi J, Nagase K, Yajima H, Yamato M, et al. Simultaneous enhancement of cell proliferation and thermally induced harvest efficiency based on temperature-responsive cationic copolymergrafted microcarriers. Biomacromolecules 2012;13:1765-73.
95. Nagase K, Mukae N, Kikuchi A, Okano T. Thermally modulated retention of lymphoctytes on polymer-brush-grafted glass beads. Macromol Biosci 2012;12:333-40.
96. Tamura A, Kobayashi J, Yamato M, Okano T. Thermally responsive microcarriers with optimal poly(N-isopropylacrylamide) grafted density for facilitating cell adhesion/detachment in suspension culture. Acta Biomater 2012;8:3904-13.
97. Nagase K, Kimura A, Shimizu T, Matsuura K, Yamato M, Takeda N, et al. Dynamically cell separating thermo-functional biointerfaces with densely packed polymer brushes. J Mater Chem 2012;22:19514-22.
98. Nagase K, Hatakeyama Y, Shimizu T, Matsuura K, Yamato M, Takeda N, et al. Hydrophobized thermoresponsive copolymer brushes for cell separation by multistep temperature change. Biomacromolecules 2013;14:3423-33.
99. Arisaka Y, Kobayashi J, Yamato M, Akiyama Y, Okano T. Switching of cell growth/detachment on heparin-functionalized thermoresponsive surface for rapid cell sheet fabrication and manipulation. Biomaterials 2013;34: 4214-22.
100. Halperin A, Kroger M. Theoretical considerations on mechanisms of harvesting cells cultured on thermoresponsive polymer brushes. Biomaterials 2012;33:4975-87.
101. Choi S, Choi BC, Xue CY, Leckband D. Protein adsorption mechanisms determine the efficiency of thermally controlled cell adhesion on poly(Nisopropyl acrylamide) brushes. Biomacromolecules 2013;14:92-100.
102. Xue CY, Choi BC, Choi S, Braun PV, Leckband DE. Protein adsorption modes determine reversible cell attachment on poly(N-isopropyl acrylamide) brushes. Adv Funct Mater 2012;22:2394-401.
103. Nishida K, Yamato M, Hayashida Y, Watanabe K, Yamamoto K, Adachi E, et al. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. New Engl J Med 2004;351:1187-96.
104. Kobayashi T, Kan K, Nishida K, Yamato M, Okano T. Corneal regeneration by transplantation of corneal epithelial cell sheets fabricated with automated cell culture system in rabbit model. Biomaterials 2013;34:9010-7.
105. Ohki T, Yamato M, Murakami D, Takagi R, Yang J, Namiki H, et al. Treatment of oesophageal ulcerations using endoscopic transplantation of tissueengineered autologous oral mucosal epithelial cell sheets in a canine model. Gut 2006;55:1704-10.
106. Yu Q, Zhang YX, Chen H, Zhou F, Wu ZQ, Huang H, et al. Protein adsorption and cell adhesion/detachment behavior on dual-responsive silicon surfaces modified with poly(N-isopropylacrylamide)-block-polystyrene copolymer. Langmuir 2010;26:8582-8.
107. Li LH, Wu JD, Gao CY. Gradient immobilization of a cell adhesion RGD peptide on thermal responsive surface for regulating cell adhesion and detachment. Colloid Surface B 2011;85:12-8.
108. Petrie TA, Raynor JE, Dumbauld DW, Lee TT, Jagtap S, Templeman KL, et al. Multivalent integrin-specific ligands enhance tissue healing and biomaterial integration. Sci Transl Med 2010;2:45ra60.
109. Steinbach A, Tautzenberger A, Ignatius A, Pluntke M, Marti O, Volkmer D. Coatings from micropatterned sulfobetaine polymer brushes as substrates for MC3T3-E1 cells. J Mater Sci 2012;23:573-9.
110. Deng Y, Zhang X, Zhao X, Li Q, Ye Z, Li Z, et al. Long-term self-renewal of human pluripotent stem cells on peptide-decorated poly(OEGMA-co-HEMA) brushes under fully defined conditions. Acta Biomater 2013;9:8840-50.
111. Tsai HA, Shen CN, Chang YC. Use of surface properties to control the growth and differentiation of mouse fetal liver stem/progenitor cell colonies. Biomacromolecules 2012;13:3483-93.
112. Villa-Diaz LG, Nandivada H, Ding J, Nogueira-de-Souza NC, Krebsbach PH, O'Shea KS, et al. Synthetic polymer coatings for long-term growth of human embryonic stem cells. Nat Biotechnol 2010;28:581-3.
113. Chang Y, Higuchi A, Shih YJ, Li PT, Chen WY, Tsai EM, et al. Bioadhesive control of plasma proteins and blood cells from umbilical cord blood onto the interface grafted with zwitterionic polymer brushes. Langmuir 2012;28:4309-17.
114. Tan KY, Lin H, Ramstedt M, Watt FM, Huck WT, Gautrot JE. Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns. Integrative biology: quantitative biosciences from nano to macro 2013;5:899-910.
115. Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WT, et al. Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials 2012;33:5221-9.
116. Kloxin AM, Kasko AM, Salinas CN, Anseth KS. Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 2009;324: 59-63.
117. Hahn MS, Miller JS, West JL. Three-dimensional biochemical and biomechanical patterning of hydrogels for guiding cell behavior. Adv Mater 2006;18:2679-84.
118. Lutolf MR, Weber FE, Schmoekel HG, Schense JC, Kohler T, Muller R, et al. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 2003;21:513-8.
119. Lutolf MP, Hubbell JA. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 2005;23:47-55.
120. Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, et al. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Proc Natl Acad Sci U S A 2003;100:5413-8.
121. Wylie RG, Ahsan S, Aizawa Y, Maxwell KL, Morshead CM, Shoichet MS. Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels. Nat Mater 2011;10:799-806.