Conjugates of superoxide dismutase 1 with amphiphilic poly(2-oxazoline) block copolymers for enhanced brain delivery: Synthesis, characterization and evaluation in vitro and in vivo

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 360-377

  Tong, Jing ^a,b   Yi, Xiang ^c   Luxenhofer, Robert ^d   Banks, William A ^e   Jordan, Rainer ^f   Zimmerman, Matthew C ^a,b   Kabanov, Alexander V ^c,g  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c University of North Carolina   (United States)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^g MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

blood brain barrier; endocytosis; neurons; oxidative stress; pharmacokinetics; polymer therapeutics; polyoxazoline; reactive oxygen species; superoxide dismutase 1

Indexed keywords

2 BUTYL 2 OXAZOLINE; 2 ETHYL 2 OXAZOLINE; 2 METHYL 2 OXAZOLINE; ALBUMIN; AMINO ACID; ANGIOTENSIN II; COPOLYMER; COPPER ZINC SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BLOOD BRAIN BARRIER; CAVEOLA; CELL LYSATE; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; DRUG UPTAKE; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID RAFT; MITOCHONDRION; NERVE CELL; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE;

ANGIOTENSIN II; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; HALF-LIFE; MALE; MICE; MITOCHONDRIA; NEURONS; OXAZOLES; POLYETHYLENE GLYCOLS; POLYMERS; SUPEROXIDE DISMUTASE; SUPEROXIDES; TISSUE DISTRIBUTION;

EID: 84872137255     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300496x     Document Type: Article

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