SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 10, 2014, Pages 2368-2373

Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease

(6) Xu, Zi Chen a Wang, Xiao Bing a Yu, Wen Ying a Xie, Sai Sai a Li, Su Yi a Kong, Ling Yi a

a CHINA PHARMACEUTICAL UNIVERSITY (China)

Author keywords

Alzheimer's disease; Benzylisoquinoline derivatives; Cholinesterase inhibitors; Human cholinesterase inhibitors; Low cell toxicity; Amyloid aggregation

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; BENZYLISOQUINOLINE DERIVATIVE; CHOLINESTERASE; GALANTAMINE; HETEROCYCLIC COMPOUND; RESVERATROL; CHOLINESTERASE INHIBITOR;

ALZHEIMER DISEASE; ARTICLE; BIOLOGICAL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NEUROBLASTOMA CELL; PROTEIN AGGREGATION; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

ALZHEIMER DISEASE; BENZYLISOQUINOLINES; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899627352 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.03.058 Document Type: Article

Times cited : (10)

References (44)

1
- 0242475195
- I. Dorronsoro, A. Castro, and A. Martinez Expert Opin. Ther. Patents 13 2003 1725
- (2003) Expert Opin. Ther. Patents , vol.13 , pp. 1725
- Dorronsoro, I.¹ Castro, A.² Martinez, A.³

2
- 40949160570
- S.D. Bembenek, J.M. Keith, M.A. Letavic, R. Apodaca, A.J. Barbier, L. Dvorak, L. Aluisio, K.L. Miller, T.W. Lovenberg, and N.I. Carruthers Bioorg. Med. Chem. 16 2008 2968
- (2008) Bioorg. Med. Chem. , vol.16 , pp. 2968
- Bembenek, S.D.¹ Keith, J.M.² Letavic, M.A.³ Apodaca, R.⁴ Barbier, A.J.⁵ Dvorak, L.⁶ Aluisio, L.⁷ Miller, K.L.⁸ Lovenberg, T.W.⁹ Carruthers, N.I.¹⁰

3
- 33644867461
- J.L. Cummings Rev. Neurol. Dis. 1 2004 60
- (2004) Rev. Neurol. Dis. , vol.1 , pp. 60
- Cummings, J.L.¹

4
- 75449102536
- H.W. Querfurth, and F.M. LaFerla New Engl. J. Med. 362 2010 329
- (2010) New Engl. J. Med. , vol.362 , pp. 329
- Querfurth, H.W.¹ Laferla, F.M.²

5
- 33750883640
- A. Castro, and A. Martínez Curr. Pharm. Des. 12 2006 4377
- (2006) Curr. Pharm. Des. , vol.12 , pp. 4377
- Castro, A.¹ Martínez, A.²

6
- 0042020173
- E. Scarpini, P. Scheltens, and H. Feldman Lancet Neurol. 2 2003 539
- (2003) Lancet Neurol. , vol.2 , pp. 539
- Scarpini, E.¹ Scheltens, P.² Feldman, H.³

7
- 0019972810
- R.T. Bartus, R.L. Dean, B. Beer, and A.S. Lippa Science 217 1982 408
- (1982) Science , vol.217 , pp. 408
- Bartus, R.T.¹ Dean, R.L.² Beer, B.³ Lippa, A.S.⁴

8
- 44949229187
- S. Butini, G. Campiani, M. Borriello, S. Gemma, A. Panico, M. Persico, B. Catalanotti, S. Ros, M. Brindisi, M. Agnusdei, I. Fiorini, V. Nacci, E. Novellino, T. Belinskaya, A. Saxena, and C. Fattorusso J. Med. Chem. 51 2008 3154
- (2008) J. Med. Chem. , vol.51 , pp. 3154
- Butini, S.¹ Campiani, G.² Borriello, M.³ Gemma, S.⁴ Panico, A.⁵ Persico, M.⁶ Catalanotti, B.⁷ Ros, S.⁸ Brindisi, M.⁹ Agnusdei, M.¹⁰ Fiorini, I.¹¹ Nacci, V.¹² Novellino, E.¹³ Belinskaya, T.¹⁴ Saxena, A.¹⁵ Fattorusso, C.¹⁶

9
- 0035661483
- N.H. Greig, T. Utsuki, Q. Yu, X. Zhu, H.W. Holloway, T. Perry, B. Lee, D.K. Ingram, and D.K. Lahiri Curr. Med. Res. Opin. 17 2001 159
- (2001) Curr. Med. Res. Opin. , vol.17 , pp. 159
- Greig, N.H.¹ Utsuki, T.² Yu, Q.³ Zhu, X.⁴ Holloway, H.W.⁵ Perry, T.⁶ Lee, B.⁷ Ingram, D.K.⁸ Lahiri, D.K.⁹

10
- 84899635726
- A. Alejandra, Br. Francisca, A.P. Cristian, V. Matias, G. Jorge, and C.I. Nibaldo Neurosci. Lett. 201 1995 49
- (1995) Neurosci. Lett. , vol.201 , pp. 49
- Alejandra, A.¹ Francisca, Br.² Cristian, A.P.³ Matias, V.⁴ Jorge, G.⁵ Nibaldo, C.I.⁶

11
- 84899638218
- C.I. Nibaldo, A. Alejandra, A.P. Cristian, D.M. Ricardo, V. Matias, L. Claudia, I.C. Olivia, S. Claudio, and G. Jorge Neuron 16 1996 881
- (1996) Neuron , vol.16 , pp. 881
- Nibaldo, C.I.¹ Alejandra, A.² Cristian, A.P.³ Ricardo, D.M.⁴ Matias, V.⁵ Claudia, L.⁶ Olivia, I.C.⁷ Claudio, S.⁸ Jorge, G.⁹

12
- 45749094206
- M. Harel, L.K. Sonoda, I. Silman, J.L. Sussman, and T.L. Rosenberry J. Am. Chem. Soc. 130 2008 7856
- (2008) J. Am. Chem. Soc. , vol.130 , pp. 7856
- Harel, M.¹ Sonoda, L.K.² Silman, I.³ Sussman, J.L.⁴ Rosenberry, T.L.⁵

13
- 12144257246
- M.L. Bolognesi, V. Andrisano, M. Bartolini, R. Banzi, and C. Melchiorre J. Med. Chem. 48 2005 24
- (2005) J. Med. Chem. , vol.48 , pp. 24
- Bolognesi, M.L.¹ Andrisano, V.² Bartolini, M.³ Banzi, R.⁴ Melchiorre, C.⁵

14
- 84856914519
- M.I. Fernandez-Bachiller, C. Perez, L. Monjas, J. Rademann, and M.I. Rodriguez-Franco J. Med. Chem. 55 2012 1303
- (2012) J. Med. Chem. , vol.55 , pp. 1303
- Fernandez-Bachiller, M.I.¹ Perez, C.² Monjas, L.³ Rademann, J.⁴ Rodriguez-Franco, M.I.⁵

15
- 0018129338
- E.K. Perry, R.H. Perry, G. Blessed, and B.E. Tomlinson Neuropathol. Appl. Neurobiol. 4 1978 273
- (1978) Neuropathol. Appl. Neurobiol. , vol.4 , pp. 273
- Perry, E.K.¹ Perry, R.H.² Blessed, G.³ Tomlinson, B.E.⁴

16
- 84874648846
- L.P. Jameson, and S.V. Dzyuba Bioorg. Med. Chem. Lett. 23 2013 1732
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 1732
- Jameson, L.P.¹ Dzyuba, S.V.²

17
- 79953165434
- Y.P. Li, F.X. Ning, M.B. Yang, Y.C. Li, M.H. Nie, T.M. Ou, J.H. Tan, S.L. Huang, D. Li, L.Q. Gu, and Z.S. Huang Eur. J. Med. Chem. 46 2011 1572
- (2011) Eur. J. Med. Chem. , vol.46 , pp. 1572
- Li, Y.P.¹ Ning, F.X.² Yang, M.B.³ Li, Y.C.⁴ Nie, M.H.⁵ Ou, T.M.⁶ Tan, J.H.⁷ Huang, S.L.⁸ Li, D.⁹ Gu, L.Q.¹⁰ Huang, Z.S.¹¹

18
- 84871718878
- H.M. Li, J. Qin, P. Dhondi, W. Zhou, M. Vicarel, T. Bara, C. David, H. Josien, D. Pissarnitski, Z.N. Zhu, A. Palani, R. Aslanian, J. Clader, M. Czarnieckia, W. Greenlee, M. Cohen-Williams, L. Hyde, L.X. Song, L.L. Zhang, I.H. Chu, and X.H. Huang Bioorg. Med. Chem. Lett. 23 2013 466
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 466
- Li, H.M.¹ Qin, J.² Dhondi, P.³ Zhou, W.⁴ Vicarel, M.⁵ Bara, T.⁶ David, C.⁷ Josien, H.⁸ Pissarnitski, D.⁹ Zhu, Z.N.¹⁰ Palani, A.¹¹ Aslanian, R.¹² Clader, J.¹³ Czarnieckia, M.¹⁴ Greenlee, W.¹⁵ Cohen-Williams, M.¹⁶ Hyde, L.¹⁷ Song, L.X.¹⁸ Zhang, L.L.¹⁹ Chu, I.H.²⁰ Huang, X.H.²¹ more..

19
- 84868517170
- H.B. Huang, D.S. La, A.C. Cheng, D.A. Whittington, V.F. Patel, K. Chen, T.A. Dineen, O. Epstein, R. Graceffa, D. Hickman, Y.H. Kiang, S. Louie, Y. Luo, R.C. Wahl, P.H. Wen, S. Wood, and R.T. Fremeau Jr. J. Med. Chem. 55 2012 9156
- (2012) J. Med. Chem. , vol.55 , pp. 9156
- Huang, H.B.¹ La, D.S.² Cheng, A.C.³ Whittington, D.A.⁴ Patel, V.F.⁵ Chen, K.⁶ Dineen, T.A.⁷ Epstein, O.⁸ Graceffa, R.⁹ Hickman, D.¹⁰ Kiang, Y.H.¹¹ Louie, S.¹² Luo, Y.¹³ Wahl, R.C.¹⁴ Wen, P.H.¹⁵ Wood, S.¹⁶ Fremeau, Jr.R.T.¹⁷

20
- 84881376332
- D. Oehlrich, F.J.R. Rombouts, D. Berthelot, F.P. Bischoff, M.A.J. De Cleyn, L. Jaroskova, G. Macdonald, M. Mercken, and M. Surkyn Bioorg. Med. Chem. Lett. 23 2013 4794
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 4794
- Oehlrich, D.¹ Rombouts, F.J.R.² Berthelot, D.³ Bischoff, F.P.⁴ De Cleyn, M.A.J.⁵ Jaroskova, L.⁶ Macdonald, G.⁷ Mercken, M.⁸ Surkyn, M.⁹

21
- 84876135019
- S. Bag, S. Ghosh, R. Tulsan, A. Sood, W.H. Zhou, C. Schifone, M. Foster, H. LeVine III, B. Török, and M. Török Bioorg. Med. Chem. Lett. 23 2013 2614
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2614
- Bag, S.¹ Ghosh, S.² Tulsan, R.³ Sood, A.⁴ Zhou, W.H.⁵ Schifone, C.⁶ Foster, M.⁷ Levine III, H.⁸ Török, B.⁹ Török, M.¹⁰

22
- 34250872774
- A. Cavalli, M.L. Bolognesi, S. Capsoni, V. Andrisano, M. Bartolini, E. Margotti, A. Cattaneo, M. Recanatini, and C. Melchiorre Angew. Chem., Int. Ed. 46 2007 3689
- (2007) Angew. Chem., Int. Ed. , vol.46 , pp. 3689
- Cavalli, A.¹ Bolognesi, M.L.² Capsoni, S.³ Andrisano, V.⁴ Bartolini, M.⁵ Margotti, E.⁶ Cattaneo, A.⁷ Recanatini, M.⁸ Melchiorre, C.⁹

23
- 33644851841
- D. Muñoz-Torrero, and P. Camps Curr. Med. Chem. 13 2006 399
- (2006) Curr. Med. Chem. , vol.13 , pp. 399
- Muñoz-Torrero, D.¹ Camps, P.²

24
- 0037413568
- L. Savini, A. Gaeta, C. Fattorusso, B. Catalanotti, G. Campiani, L. Chiasserini, C. Pellerano, E. Novellino, D. McKissic, and A. Saxena J. Med. Chem. 46 2003 1
- (2003) J. Med. Chem. , vol.46 , pp. 1
- Savini, L.¹ Gaeta, A.² Fattorusso, C.³ Catalanotti, B.⁴ Campiani, G.⁵ Chiasserini, L.⁶ Pellerano, C.⁷ Novellino, E.⁸ McKissic, D.⁹ Saxena, A.¹⁰

25
- 33748540091
- M. Decker J. Med. Chem. 49 2006 5411
- (2006) J. Med. Chem. , vol.49 , pp. 5411
- Decker, M.¹

26
- 84875209476
- A. Romero, R. Cacabelos, M.J. Oset-Gasque, A. Samadi, and J. Marco-Contelles Bioorg. Med. Chem. Lett. 23 2013 1916
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 1916
- Romero, A.¹ Cacabelos, R.² Oset-Gasque, M.J.³ Samadi, A.⁴ Marco-Contelles, J.⁵

27
- 84867842173
- L. Moreno, P. Párraga, A. Galán, N. Cabedo, J. Primo, and D. Cortes Bioorg. Med. Chem. 20 2012 6589
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 6589
- Moreno, L.¹ Párraga, P.² Galán, A.³ Cabedo, N.⁴ Primo, J.⁵ Cortes, D.⁶

28
- 84862973441
- Q.Q. Huang, J.L. Bi, Q.Y. Sun, F.M. Yang, Y.H. Wang, G.H. Tang, F.W. Zhao, H. Wang, J.J. Xu, E.J. Kennelly, C.L. Long, and G.F. Yin Planta Med. 78 2012 65
- (2012) Planta Med. , vol.78 , pp. 65
- Huang, Q.Q.¹ Bi, J.L.² Sun, Q.Y.³ Yang, F.M.⁴ Wang, Y.H.⁵ Tang, G.H.⁶ Zhao, F.W.⁷ Wang, H.⁸ Xu, J.J.⁹ Kennelly, E.J.¹⁰ Long, C.L.¹¹ Yin, G.F.¹²

29
- 77952288966
- L.B. Pagliosa, S.C. Monteiro, K.B. Silva, J.P. de Andrade, J. Dutilh, J. Bastida, M. Cammarota, and J.A.S. Zuanazzi Phytomedicine 17 2010 698
- (2010) Phytomedicine , vol.17 , pp. 698
- Pagliosa, L.B.¹ Monteiro, S.C.² Silva, K.B.³ De Andrade, J.P.⁴ Dutilh, J.⁵ Bastida, J.⁶ Cammarota, M.⁷ Zuanazzi, J.A.S.⁸

30
- 33646449778
- K. Ingkaninan, P. Phengpa, S. Yuenyongsawad, and N. Khorana J. Pharm. Pharmacol. 58 2006 695
- (2006) J. Pharm. Pharmacol. , vol.58 , pp. 695
- Ingkaninan, K.¹ Phengpa, P.² Yuenyongsawad, S.³ Khorana, N.⁴

31
- 84867891033
- G. Brunhofer, A. Fallarero, D. Karlsson, A. Batista-Gonzalez, P. Shinde, C.G. Mohan, and P. Vuorela Bioorg. Med. Chem. 20 2012 6669
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 6669
- Brunhofer, G.¹ Fallarero, A.² Karlsson, D.³ Batista-Gonzalez, A.⁴ Shinde, P.⁵ Mohan, C.G.⁶ Vuorela, P.⁷

32
- 33644802779
- S. Markmee, S. Ruchirawat, V. Prachyawarakorn, K. Ingkaninan, and N. Khorana Bioorg. Med. Chem. Lett. 16 2006 2170
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 2170
- Markmee, S.¹ Ruchirawat, S.² Prachyawarakorn, V.³ Ingkaninan, K.⁴ Khorana, N.⁵

33
- 74949099493
- M. Valpuesta, M. Ariza, A. Diaz, G. Torres, and R. Suau Eur. J. Org. Chem. 23 2010 638
- (2010) Eur. J. Org. Chem. , vol.23 , pp. 638
- Valpuesta, M.¹ Ariza, M.² Diaz, A.³ Torres, G.⁴ Suau, R.⁵

34
- 84862822299
- H. Zhai, J. Miller, and G. Sammis Bioorg. Med. Chem. Lett. 22 2012 1557
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 1557
- Zhai, H.¹ Miller, J.² Sammis, G.³

35
- 79952195502
- M.El. Arbi, P. Pigeon, S. Top, A. Rhouma, S. Aifa, A. Rebai, A. Vessières, M.A. Plamont, and G. Jaouen J. Organomet. Chem. 696 2011 1038
- (2011) J. Organomet. Chem. , vol.696 , pp. 1038
- Arbi, M.El.¹ Pigeon, P.² Top, S.³ Rhouma, A.⁴ Aifa, S.⁵ Rebai, A.⁶ Vessières, A.⁷ Plamont, M.A.⁸ Jaouen, G.⁹

36
- 33644811612
- G.L. Ellman, K.D. Courtney, V. Andres Jr., and R.M. Featherstone Biochem. Pharmacol. 7 1961 88
- (1961) Biochem. Pharmacol. , vol.7 , pp. 88
- Ellman, G.L.¹ Courtney, K.D.² Andres, Jr.V.³ Featherstone, R.M.⁴

37
- 84862159765
- F.C. Meng, F. Mao, W.J. Shan, F. Qin, L. Huang, and X.S. Li Bioorg. Med. Chem. Lett. 22 2012 4462
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 4462
- Meng, F.C.¹ Mao, F.² Shan, W.J.³ Qin, F.⁴ Huang, L.⁵ Li, X.S.⁶

38
- 84876120908
- R.S. Li, X.B. Wang, X.J. Hu, and L.Y. Kong Bioorg. Med. Chem. Lett. 23 2013 2636
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2636
- Li, R.S.¹ Wang, X.B.² Hu, X.J.³ Kong, L.Y.⁴

39
- 0037435051
- V. Tumiatti, M. Rosini, M. Bartolini, A. Cavalli, G. Marucci, V. Andrisano, P. Angeli, R. Banzi, A. Minarini, M. Recanatini, and C. Melchiorre J. Med. Chem. 46 2003 954
- (2003) J. Med. Chem. , vol.46 , pp. 954
- Tumiatti, V.¹ Rosini, M.² Bartolini, M.³ Cavalli, A.⁴ Marucci, G.⁵ Andrisano, V.⁶ Angeli, P.⁷ Banzi, R.⁸ Minarini, A.⁹ Recanatini, M.¹⁰ Melchiorre, C.¹¹

40
- 33750933907
- L. Piazzi, F. Belluti, A. Bisi, S. Gobbi, S. Rizzo, M. Bartolini, V. Andrisano, M. Recanatini, and A. Rampa Bioorg. Med. Chem. 15 2007 575
- (2007) Bioorg. Med. Chem. , vol.15 , pp. 575
- Piazzi, L.¹ Belluti, F.² Bisi, A.³ Gobbi, S.⁴ Rizzo, S.⁵ Bartolini, M.⁶ Andrisano, V.⁷ Recanatini, M.⁸ Rampa, A.⁹

41
- 36849078628
- M. Bartolini, C. Bertucci, M.L. Bolognesi, A. Cavalli, C. Melchiorre, and V. Andrisano ChemBioChem 8 2007 2152
- (2007) ChemBioChem , vol.8 , pp. 2152
- Bartolini, M.¹ Bertucci, C.² Bolognesi, M.L.³ Cavalli, A.⁴ Melchiorre, C.⁵ Andrisano, V.⁶

42
- 80052567229
- S.Y. Chen, Y. Chen, Y.P. Li, S.H. Chen, J.H. Tan, T.M. Ou, L.Q. Gu, and Z.S. Huang Bioorg. Med. Chem. 19 2011 5596
- (2011) Bioorg. Med. Chem. , vol.19 , pp. 5596
- Chen, S.Y.¹ Chen, Y.² Li, Y.P.³ Chen, S.H.⁴ Tan, J.H.⁵ Ou, T.M.⁶ Gu, L.Q.⁷ Huang, Z.S.⁸

43
- 77954331097
- M.I. Fernandez-Bachiller, C. Perez, G.C. Gonzalez-Munoz, S. Conde, M.G. Lopez, M. Villarroya, A.G. Garcia, and M.I. Rodriguez-Franco J. Med. Chem. 53 2010 4927
- (2010) J. Med. Chem. , vol.53 , pp. 4927
- Fernandez-Bachiller, M.I.¹ Perez, C.² Gonzalez-Munoz, G.C.³ Conde, S.⁴ Lopez, M.G.⁵ Villarroya, M.⁶ Garcia, A.G.⁷ Rodriguez-Franco, M.I.⁸

44
- 67650759968
- H. Zheng, M.B. Youdim, and M. Fridkin J. Med. Chem. 52 2009 4095
- (2009) J. Med. Chem. , vol.52 , pp. 4095
- Zheng, H.¹ Youdim, M.B.² Fridkin, M.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.