Protective effects of total extracts of averrhoa carambola l. (oxalidaceae) roots on streptozotocin-induced diabetic mice

Cellular Physiology and Biochemistry

Volumn 33, Issue 5, 2014, Pages 1272-1282

  Xu, Xiaohui ^a   Liang, Tao ^a   Wen, Qingwei ^a   Lin, Xing ^a   Tang, Jingzhi ^a   Zuo, Qiaoyun ^a   Tao, Liqun ^a   Xuan, Feifei ^a   Huang, Renbin ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Blood glucose; Extracts of Averrhoa carambola L. root; Pancreas

Indexed keywords

ALCOHOL; AVERRHOA CARAMBOLA EXTRACT; CASPASE 3; CASPASE 8; CASPASE 9; CHOLESTEROL; FATTY ACID; GLUCOSE; HYPERGLYCEMIC AGENT; INSULIN; METFORMIN; PLANT EXTRACT; PROTEIN BAX; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WATER; PROTEIN BCL 2; ANTIDIABETIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; AVERRHOA CARAMBOLA; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRIACYLGLYCEROL BLOOD LEVEL; DRUG DESIGN; EXPERIMENTAL MODEL; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DOSE RESPONSE; DRUG EFFECTS; INBRED MOUSE STRAIN; ISOLATION AND PURIFICATION; METABOLISM; OXALIDACEAE; STRUCTURE ACTIVITY RELATION;

AVERRHOA CARAMBOLA; MUS; OXALIDACEAE;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED STRAINS; OXALIDACEAE; PLANT ROOTS; STREPTOZOCIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899599382     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000358695     Document Type: Article

References (33)

1. Trucco M: Regeneration of the pancreatic p cell. J Ciln Invest 2005;115:5-12.
2. Eisenbarth G: Type I diabetes mellitus. A chronic autoimmune disease. New Engl Med 1986;314:1360-1368. (Pubitemid 16122469)
3. Bresson D, Von Herrath M: Moving towards efficient therapies in type 1 diabetes: To combine or not to combine Autoimmun Rev 2007;6:315-322. (Pubitemid 46507996)
4. Muller N, Kloos C, Samann A, Wolf G, Mul ler UA: Evaluation of a treatment and teaching refresher programme for the optimization of intensified insulin therapy in type 1 diabetes. Patient Educ Couns 2013;93:108-113.
5. Nyenwe EA, Jerkins TW, Umpierr ez GE, Kitabchi AE: Management of type 2 diabetes: Evolving strategies for the treatment of patients with type 2 diabetes. Metab 2011;60:1-23.
6. Saravanan G, Ponmurugan P: Ameliorative potential of S-al lylcysteine: Effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Exp Toxicol Pathol 2012;64:639-644.
7. Ogbonnia S, Odimegwu J, Enwuru V: Evaluation of hypoglycemic and hypolipidemic effects of aqueous ethanolic extracts of Treculia africana Decne and Bryophyllum pinnatum, Lam. and their mixture on streptozotocin (STZ)-induced diabetic rats. Afr J Biotechnol 2008;7:2535-2539.
8. Subra manian S, Chait A: Hypertriglyceridemia secondary to obesity and diabetes. BBA-Mol Cell Biol L 2012;1821:819-825.
9. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H: TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006;116:3015-3025. (Pubitemid 44684486)
10. Mehmeti I, Gurgul-Convey E, Lenzen S, Lortz S: Induction of the intrinsic apoptosis pathway in insulinsecreting cells is dependent on oxidative da mage of mitochondria but independent of caspase-12 activation. BBA-Mol Cell Res 2011;1813:1827-1835.
11. Grutter MG: Caspases: Key players in programmed cell death. Curr Opin Struc Biol 2000;10:649-655. (Pubitemid 32061479)
12. Chowdhury I, Tharakan B, Bhat GK: Caspases-an update. Comp Biochem Phys Biol 2008;151:10-27.
13. Turk B, Stoka V: Protease signalling in cell death: Caspases versus cysteine cathepsins. Febs Lettt 2007;581:2761-2767. (Pubitemid 46874395)
14. Juo P Kuo CJ Yuan J Blenis J Essential requirement for caspase-8/FLICE in the initiation of the Fasinduced apoptotic cascade Curr Biol 1998 8 1001-1008. (Pubitemid 28448072)
15. Johnson JD, Luciani DS: Mecha nisms of pancreatic p-cell apoptosis in diabetes and its therapies. Adv Exp Med Biol 2010;654:447-62.
16. Luo XY, Huang JC, Yang X, Wang LH, Huang RB: Antioxidative Effect of Yangtaogen Polysaccharide in vitro. Chin J Exp Trad Med Form 2011;4:35-38.
17. Huang GH, He M, Lin X, Huang RB: Hypoglycemic effect of alcoholic extracts of Averrhoa carambola in STZinduced diabetic mice. Chin J HospPharm 2009;15:3-8.
18. Zheng N, Lin X, Wen Q, Zhang S, Huang J: Effect of 2-dodecyl-6- methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L. (O xalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice. Toxicol Lett 2013;19:77-84.
19. Wen Q, Liang T, Qin F, Wei J, He Q: Lyoniresinol 3a-O-p-D-Glucopyrano side-Mediated Hypoglycaemia and Its Influence on Apoptosis-Regulatory Protein Expression in the Injured Kidneys of Streptozotocin-Induced Mice. PloS One 2013;8:e81772.
20. Cazarolli LH, Kappel VD, Pereira DF, M oresco HH, Brighente IMC: Anti-hyperglycemic action of apigenin-6-C-p-fucopyranoside from Averrhoa carambola. Fitoterapia 2012; 3:1176-1183.
21. Carolino RO, Beleboni RO, Pizzo AB, Vecchio FD, Garc ia-Cairasco N: Convulsant activity and neurochemical alterations induced by a fraction obtained from fruit Averrhoa carambola (Oxalidaceae: Geraniales). Neurochem Int 2005;46:523-531. (Pubitemid 40544399)
22. Luo XY, Huang JC, Yang X, Wang LH, Huang RB: Antioxidative effect of Yangtaogen (carambala root) polysaccharide (YTGP) in vitro. Chin J Hosp Pharm 2011;14:7-9.
23. Wen Q, Lin X, Liu Y, Xu X, Liang T: Phenolic and Lignan Glycosides from the Butanol Extract of Averrhoa carambola L. Root. Molecules 2012;17:12330-12340.
24. Zhang M, Lv X-Y, Li J, Xu Z-G, Chen L: The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res DOI:10.1155/2008/704045.
25. Zhao YF, Feng DD, Chen C: Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes. Int J Biochem Cell B 2006;38:804-819. (Pubitemid 43363413)
26. Gleason CE, Gonzalez M, Harmon JS, Robertson RP: Determinants of glucose toxicity and its reversibility in the pancreatic islet p-cell line, HIT-T15. Am J Physiol-Endoc M 2000;279:997-1002.
27. Itoh Y, Hinuma S: GPR40, a free fatty acid receptor on pancreatic p cells, regulates insulin secretion. Hepatol Res 2005;33:171-173. (Pubitemid 41799798)
28. Daneshgari F, Leiter EH, Liu G, Reeder J: Animal models of diabetic uropathy. J Urology 2009;182:8-13.
29. Bruckbauer A, Zemel MB: Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity. Diabetes Metab Syndr Obes 2013;6:93-102.
30. Leahy JL, Bonner-Weir S, Weir GC: P-Cell dysfunction induced by chronic hyperglycemia: Current ideas on mechanism of impaire d glucose-induced insulin secretion. Diabetes Care 1992;15:442-455.
31. Kurrer MO, Pakala SV, Hanson HL, Katz JD: P cell apoptosis in T cell-mediated autoimmune diabetes. P Natl Acad Sci 1997;94:213-218. (Pubitemid 27027189)
32. De Martino L, Marfe G, Longo M, Fiorito F, Montagnaro S: Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis. Vet Microbiol 2010;141:36-45.
33. Dejean LM, Martinez-Caballero S, Manon S, Kinnally KW: Regulation of the mitochondrial apoptosisinduced channel, MAC, by BCL-2 family proteins. BBA-Mol Basis Dis 2006;1762:191-201. (Pubitemid 43006025)