Triaryl-substituted schiff bases are high-affinity subtype-selective ligands for the estrogen receptor

Journal of Medicinal Chemistry

Volumn 57, Issue 8, 2014, Pages 3532-3545

  Liao, Zong Quan ^a   Dong, Chune ^a   Carlson, Kathryn E ^b   Srinivasan, Sathish ^d   Nwachukwu, Jerome C ^d   Chesnut, Robert W ^c   Sharma, Abhishek ^b   Nettles, Kendall W ^d   Katzenellenbogen, John A ^b   Zhou, Hai Bing ^a  

^a WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c EASTERN ILLINOIS UNIVERSITY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' [(2 TOLYLIMINO)METHYLENE]DIPHENOL; 4,4' [(3 TOLYLIMINO)METHYLENE]DIPHENOL; 4,4' [(4 TOLYLIMINO)METHYLENE]DIPHENOL; 4,4' [(PHENYLIMINO)METHYLENE]DIPHENOL; 4,4' [[(2 CHLOROPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[(2,6 DIMETHYLPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[(3 CHLOROPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[(4 BROMOPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[(4 CHLOROPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[(4 FLUOROPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[(4 HYDROXYPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[(4 METHOXYPHENYL)IMINO]METHYLENE]DIPHENOL; 4,4' [[[3 (TRIFLUOROMETHYL)PHENYL]IMINO]METHYLENE]DIPHENOL; ANILINE DERIVATIVE; BENZOPHENONE DERIVATIVE; IMINE; LIGAND; SCHIFF BASE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL ASSAY; COVALENT BOND; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY;

IMINES; LIGANDS; RECEPTORS, ESTROGEN; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 84899584090     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500268j     Document Type: Article

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