Berberine induces double-strand DNA breaks in Rev3 deficient cells

Molecular Medicine Reports

Volumn 9, Issue 5, 2014, Pages 1883-1888

  Hu, Xiao Juan ^a   Wu, Xiaohua ^b   Huang, Yunfei ^c   Tong, Qingyi ^b   Takeda, Shunichi ^d   Qing, Yong ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c Sichuan Academy of Chinese Medicine Sciences   (China)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Berberine; DNA repair; DT40 cells; Rev3

Indexed keywords

BERBERINE; DNA;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA REPAIR; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; G2 PHASE CELL CYCLE CHECKPOINT; GENE; MOLECULAR CLONING; NONHUMAN; REV3 GENE; WILD TYPE;

BERBERINE; CELL LINE; CHROMOSOME BREAKAGE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS;

EID: 84899548022     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.1999     Document Type: Article

References (38)

1. Yin J, Ye JP and Jia WP: Effects and mechanisms of berberine in diabetes treatment. Acta Pharmaceutica Sinica Sin B 2: 327-334, 2012.
2. Takase H, Yamamoto K, Ito K and Yumioka E: Pharmacological studies on antidiarrheal effects of berberine and geranii herba. Nihon Yakurigaku Zasshi 102: 101-112, 1993 (In Japanese). (Pubitemid 23278238)
3. Lin JP, Yang JS, Lee JH, Hsieh WT and Chung JG: Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World J Gastroenterol 12: 21-28, 2006.
4. Lin CC, Kao ST, Chen GW, Ho HC and Chung JG: Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 26: 227-242, 2006.
5. Sanders MM, Liu AA, Li TK, Wu HY, Desai SD, Mao Y, Rubin EH, LaVoie EJ, Makhey D and Liu LF: Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells. Biochem Pharmacol 56: 1157-1166, 1998. (Pubitemid 28511238)
6. Liu Q, Jiang H, Liu Z, Wang Y, Zhao M, Hao C, Feng S, Guo H, Xu B, Yang Q, et al: Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51. PLoS ONE 6: e23427, 2011.
7. Wang J, Liu Q and Yang QF: Radiosensitization effects of berberine on human breast cancer cells. Int J Mol Med 30: 1166-1172, 2012.
8. Liu ZJ, Liu Q, Xu B, Wu JJ, Guo C, Zhu FL, Yang QZ, Gao GM, Gong YQ and Shao CS: Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res 662: 75-83, 2009.
9. Pasqual MS, Lauer CP, Moyna P and Henriques JAP: Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms. Mutat Res 286: 243-252, 1993. (Pubitemid 23103830)
10. Ho YT, Lu CC, Yang JS, Chiang JH, Li TC, Ip SW, Hsia TC, Liao CL, Lin JG, Wood WG and Chung JG: Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells. Anticancer Res 29: 4063-4070, 2009.
11. Mizutani A, Okada T, Shibutani S, Sonoda E, Hochegger H, Nishigori C, Miyachi Y, Takeda S and Yamazoe M: Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells. Cancer Res 64: 3144-3147, 2004. (Pubitemid 38581415)
12. Sonoda E, Okada T, Zhao GY, Tateishi S, Araki K, Yamaizumi M, Yagi T, Verkaik NS, van Gent DC, Takata M and Takeda S: Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates. EMBO J 22: 3188-3197, 2003. (Pubitemid 36758638)
13. Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli BJ, Bishop DK, Hirano S, Ohzeki M, Ishiai M, et al: Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res 65: 11704-11711, 2005. (Pubitemid 41821731)
14. Takezawa J, Aiba N, Kajiwara K and Yamada K: Caffeine abolishes the ultraviolet-induced REV3 translesion replication pathway in mouse cells. Int J Mol Sci 12: 8513-8529, 2011.
15. Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL and Tice RR: Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen 52: 547-561, 2011.
16. Wu XH, Takenaka K, Sonoda E, Hochegger H, Kawanishi S, Kawamoto T, Takeda S and Yamazoe M: Critical roles for polymeraseζ in cellular tolerance to nitric oxide-induced DNA damage. Cancer Res 66: 748-754, 2006. (Pubitemid 43165938)
17. Sonoda E, Sasaki MS, Buerstedde JM, Bezzubova O, Shinohara A, Ogawa H, Takata M, Yamaguchi-Iwai Y and Takeda S: Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J 17: 598-608, 1998. (Pubitemid 28045499)
18. Buerstedde JM and Takeda S: Increased ratio of targeted to random integration after transfection of chicken B cell lines. Cell 67: 179-188, 1991.
19. Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A and Takeda S: Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 17: 5497-5508, 1998. (Pubitemid 28427063)
20. Okada T, Sonoda E, Yamashita YM, Koyoshi S, Tateishi S, Yamaizumi M, Takata M, Ogawa O and Takeda S: Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage. J Biol Chem 277: 48690-48695, 2002. (Pubitemid 35470833)
21. Hossain MB, Ji P, Anish R, Jacobson RH and Takada S: Poly(ADP-ribose) Polymerase 1 interacts with nuclear respiratory factor 1 (NRF-1) and plays a role in NRF-1 transcriptional regulation. J Biol Chem 284: 8621-8632, 2008.
22. Fukushima T: Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA Double-strand break repair. J Biol Chem 276: 44413-44418, 2001.
23. Qing Y, Yamazoe M, Hirota K, Dejsuphong D, Sakai W, Yamamoto KN, Bishop DK, Wu X and Takeda S: The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet 7: e1002148, 2011.
24. Danoy P, Sonoda E, Lathrop M, Takeda S and Matsuda F: A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage. Biochem Biophys Res Commun 352: 763-768, 2007. (Pubitemid 44880321)
25. Hatanaka A, Yamazoe M, Sale JE, Takata M, Yamamoto K, Kitao H, Sonoda E, Kikuchi K, Yonetani Y and Takeda S: Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V Gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Mol Cell Biol 25: 1124-1134, 2005. (Pubitemid 40165818)
26. Ji K, Kogame T, Choi K, Wang X, Lee JY, Taniguchi Y and Takeda S: A novel approach using DNA-repair-defcient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants. Environ Health Perspect 117: 1737-1744, 2009.
27. Haracska L, Unk I, Johnson RE, Johansson E, Burgers PM, Prakash S and Prakash L: Roles of yeast DNA polymerasesδ and ζ and of Rev1 in the bypass of abasic sites. Genes Dev 15: 945-954, 2001. (Pubitemid 32323545)
28. Hochegger H, Sonoda E and Takeda S: Post-replication repair in DT40 cells: translesion polymerases versus recombinases. Bioessays 26: 151-158, 2004. (Pubitemid 38197013)
29. van Gent DC, Hoeijmakers JH and Kanaar R: Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2: 196-206, 2001. (Pubitemid 33674018)
30. Sharma S, Hicks JK, Chute CL, Brennan JR, Ahn JY, Glover TW and Canman CE: REV1 and polymeraseζ facilitate homologous recombination repair. Nucleic Acids Res 40: 682-691, 2012.
31. Venkitaraman AR: Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu Rev Pathol 4: 461-487, 2009.
32. Yamazoe M, Sonoda E, Hochegger H and Takeda S: Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40. DNA Repair (Amst) 3: 1175-1185, 2004. (Pubitemid 38997961)
33. Branzei D, Vanoli F and Foiani M: SUMOylation regulates Rad18-mediated template switch. Nature 456: 915-920, 2008.
34. Friedberg E, Lehmann A and Fuchs R: Trading places: How do DNA polymerases switch during translesion DNA synthesis? Mol Cell 18: 499-505, 2005. (Pubitemid 40726227)
35. Murakawa Y, Sonoda E, Barber LJ, Zeng W, Yokomori K, Kimura H, Niimi A, Lehmann A, Zhao GY, Hochegger H, et al: Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res 67: 8536-8543, 2007. (Pubitemid 47437428)
36. Bhat A, Andersen PL, Qin Z and, Xiao W: Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells. Nucleic Acids Res 41: 2328-2339, 2013.
37. Yoshimura A, Nishino K, Takezawa J, Tada S, Kobayashi T, Sonoda E, Kawamoto T, Takeda S, Ishii Y, Yamada K, Enomoto T and Seki M: A novel Rad18 function involved in protection of the vertebrate genome after exposure to camptothecin. DNA Repair (Amst) 5: 1307-1316, 2006. (Pubitemid 44592646)
38. Tomicic MT and Kaina B: Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors. Biochim Biophys Acta 1835: 11-27, 2013.