Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: Mechanosensitive TRPV1 as an " acupuncture-responding channel"

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Wu, Shu Yih ^a   Chen, Wei Hsin ^b   Hsieh, Ching Liang ^a,c   Lin, Yi Wen ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Acupuncture; ASIC3; Calcium wave propagation; Mechanotransduction; TRPV1; TRPV4

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 3; CAPSAICIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 4; ACCN3 PROTEIN, MOUSE; ANALGESIC AGENT; CALCIUM; TRPV1 PROTEIN, MOUSE; TRPV4 PROTEIN, MOUSE; VANILLOID RECEPTOR; GSK 1016790A; VANILLOID RECEPTOR 4 AGONIST; VANILLOID RECEPTOR AFFECTING AGENT;

ACUPUNCTURE; ACUPUNCTURE NEEDLE; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; EPIMYSIUM; INFLAMMATORY PAIN; MECHANICAL STIMULATION; MOUSE; MUSCLE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; CHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; MECHANOTRANSDUCTION; METABOLISM; NERVE FIBER; SKELETAL MUSCLE; IMMUNOFLUORESCENCE; NERVE ENDING; NERVOUS SYSTEM; STIMULATION; WESTERN BLOTTING;

ACID SENSING ION CHANNELS; ACUPUNCTURE POINTS; ANALGESICS; ANIMALS; CALCIUM; CALCIUM SIGNALING; CAPSAICIN; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED ICR; MUSCLE, SKELETAL; NERVE FIBERS; TRPV CATION CHANNELS;

EID: 84899526695     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-96     Document Type: Article

References (88)

1. Acupuncture. NIH Consensus Statement 1997, 15(5):1-34.
2. Chen YH, Ivanic B, Chuang CM, Lu DY, Lin JG. Electroacupuncture reduces cocaine-induced seizures and mortality in mice. Evid Based Complement Alternat Med 2013, 2013:134610. 3652148, 23690833.
3. Lin YW, Hsieh CL. Electroacupuncture at Baihui acupoint (GV20) reverses behavior deficit and long-term potentiation through N-methyl-d-aspartate and transient receptor potential vanilloid subtype 1 receptors in middle cerebral artery occlusion rats. J Integr Neurosci 2010, 9(3):269-282. 10.1142/S0219635210002433, 21064218.
4. Chen WH, Hsieh CL, Huang CP, Lin TJ, Tzen JT, Ho TY, Lin YW. Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain. J Biomed Sci 2011, 18:82. 10.1186/1423-0127-18-82, 3233511, 22070775.
5. Chen WH, Tzen JT, Hsieh CL, Chen YH, Lin TJ, Chen SY, Lin YW. Attenuation of TRPV1 and TRPV4 expression and function in mouse inflammatory pain models using electroacupuncture. Evid Based Complement Alternat Med 2012, 2012:636848. 3520481, 23258994.
6. Huang CP, Chen HN, Su HL, Hsieh CL, Chen WH, Lai ZR, Lin YW. Electroacupuncture reduces carrageenan- and CFA-induced inflammatory pain accompanied by changing the expression of Nav1.7 And Nav1.8, Rather than Nav1.9, In mice dorsal root ganglia. Evid Based Complement Alternat Med 2013, 2013:312184. 3615619, 23573123.
7. Vas J, Méndez C, Perea-Milla E, Vega E, Panadero MD, León JM, Borge MA, Gaspar O, Sánchez-Rodríguez F, Aguilar I, Jurado R. Acupuncture as a complementary therapy to the pharmacological treatment of osteoarthritis of the knee: randomised controlled trial. BMJ 2004, 329(7476):1216. 10.1136/bmj.38238.601447.3A, 529365, 15494348.
8. Manheimer E, Cheng K, Linde K, Lao L, Yoo J, Wieland S, van der Windt DA, Berman BM, Bouter LM. Acupuncture for peripheral joint osteoarthritis. Cochrane Database Syst Rev 2010, 2010(1):CD001977.
9. Witt CM, Ludtke R, Wegscheider K, Willich SN. Physician characteristics and variation in treatment outcomes: are better qualified and experienced physicians more successful in treating patients with chronic pain with acupuncture?. J Pain 2010, 11(5):431-435. 10.1016/j.jpain.2009.08.010, 20439056.
10. Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, Hummelsberger J, Walther HU, Melchart D, Willich SN. Acupuncture in patients with osteoarthritis of the knee: a randomised trial. Lancet 2005, 366(9480):136-143. 10.1016/S0140-6736(05)66871-7, 16005336.
11. Manheimer E, Linde K, Lao L, Bouter LM, Berman BM. Meta-analysis: acupuncture for osteoarthritis of the knee. Ann Intern Med 2007, 146(12):868-877. 10.7326/0003-4819-146-12-200706190-00008, 17577006.
12. Berman BM, Lao L, Langenberg P, Lee WL, Gilpin AM, Hochberg MC. Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial. Ann Intern Med 2004, 141(12):901-910. 10.7326/0003-4819-141-12-200412210-00006, 15611487.
13. Vickers AJ, Cronin AM, Maschino AC, Lewith G, MacPherson H, Foster NE, Sherman KJ, Witt CM, Linde K, Acupuncture Trialists C. Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med 2012, 172(19):1444-1453. 10.1001/archinternmed.2012.3654, 3658605, 22965186.
14. Mayer DJ, Price DD, Rafii A. Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone. Brain Res 1977, 121(2):368-372. 10.1016/0006-8993(77)90161-5, 832169.
15. Sjolund B, Terenius L, Eriksson M. Increased cerebrospinal fluid levels of endorphins after electro-acupuncture. Acta Physiol Scand 1977, 100(3):382-384. 10.1111/j.1748-1716.1977.tb05964.x, 920207.
16. Han JS. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci 2003, 26(1):17-22. 10.1016/S0166-2236(02)00006-1, 12495858.
17. Zhao ZQ. Neural mechanism underlying acupuncture analgesia. Prog Neurobiol 2008, 85(4):355-375. 10.1016/j.pneurobio.2008.05.004, 18582529.
18. Takano T, Chen X, Luo F, Fujita T, Ren Z, Goldman N, Zhao Y, Markman JD, Nedergaard M. Traditional acupuncture triggers a local increase in adenosine in human subjects. J Pain 2012, 13(12):1215-1223. 10.1016/j.jpain.2012.09.012, 3587733, 23182227.
19. Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci 2010, 13(7):883-888. 10.1038/nn.2562, 3467968, 20512135.
20. Sadananda P, Shang F, Liu L, Mansfield KJ, Burcher E. Release of ATP from rat urinary bladder mucosa: role of acid, vanilloids and stretch. Br J Pharmacol 2009, 158(7):1655-1662. 10.1111/j.1476-5381.2009.00431.x, 2801206, 19860742.
21. Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, De Groat WC, Apodaca G, Watkins S, Caterina MJ. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 2002, 5(9):856-860. 10.1038/nn902, 12161756.
22. Seminario-Vidal L, Okada SF, Sesma JI, Kreda SM, van Heusden CA, Zhu Y, Jones LC, O'Neal WK, Penuela S, Laird DW, Boucher RC, Lazarowski ER. Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem 2011, 286(30):26277-26286. 10.1074/jbc.M111.260562, 3143590, 21606493.
23. Mihara H, Boudaka A, Sugiyama T, Moriyama Y, Tominaga M. Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol 2011, 589(Pt 14):3471-3482. 3167111, 21540339.
24. Page AJ, Brierley SM, Martin CM, Price MP, Symonds E, Butler R, Wemmie JA, Blackshaw LA. Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut 2005, 54(10):1408-1415. 10.1136/gut.2005.071084, 1774697, 15987792.
25. Delmas P, Hao J, Rodat-Despoix L. Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci 2011, 12(3):139-153. 10.1038/nrn2993, 21304548.
26. Yamamoto H, Kawada T, Kamiya A, Miyazaki S, Sugimachi M. Involvement of the mechanoreceptors in the sensory mechanisms of manual and electrical acupuncture. Auton Neurosci 2011, 160(1-2):27-31.
27. McCarter GC, Reichling DB, Levine JD. Mechanical transduction by rat dorsal root ganglion neurons in vitro. Neurosci Lett 1999, 273(3):179-182. 10.1016/S0304-3940(99)00665-5, 10515188.
28. Takeda M, Nishikawa T, Sato S, Aiyama S, Matsumoto S. Effects of gadolinium and tetrodotoxin on the response of slowly adapting type I mechanoreceptors to mechanical stimulation in frog dorsal skin. J Peripher Nerv Syst 2003, 8(4):271-281. 10.1111/j.1085-9489.2003.03032.x, 14641651.
29. Fiacco TA, McCarthy KD. Astrocyte calcium elevations: properties, propagation, and effects on brain signaling. Glia 2006, 54(7):676-690. 10.1002/glia.20396, 17006896.
30. Zimmermann B, Walz B. The mechanism mediating regenerative intercellular Ca2+ waves in the blowfly salivary gland. EMBO J 1999, 18(12):3222-3231. 10.1093/emboj/18.12.3222, 1171403, 10369663.
31. Yao J, Suwa M, Li B, Kawamura K, Morioka T, Oite T. ATP-dependent mechanism for coordination of intercellular Ca2+ signaling and renin secretion in rat juxtaglomerular cells. Circ Res 2003, 93(4):338-345. 10.1161/01.RES.0000086802.21850.5D, 12869388.
32. Furuya K, Sokabe M, Furuya S. Characteristics of subepithelial fibroblasts as a mechano-sensor in the intestine: cell-shape-dependent ATP release and P2Y1 signaling. J Cell Sci 2005, 118(Pt 15):3289-3304.
33. Koizumi S, Fujishita K, Inoue K, Shigemoto-Mogami Y, Tsuda M, Inoue K. Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation. Biochem J 2004, 380(Pt 2):329-338. 1224173, 14967069.
34. Li G, Liang JM, Li PW, Yao X, Pei PZ, Li W, He QH, Yang X, Chan QC, Cheung PY, Ma QY, Lam SK, Cheng PY, Yang ES. Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave. Pflugers Arch 2011, 462(4):587-597. 10.1007/s00424-011-0993-7, 3170465, 21796340.
35. National Research Council Guide for the Care and Use of Laboratory Animals 2011, Washington, DC: National Academy Press, 8, National Research Council.
36. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16(2):109-110. 10.1016/0304-3959(83)90201-4, 6877845.
37. Raghavendra V, Tanga FY, DeLeo JA. Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur J Neurosci 2004, 20(2):467-473. 10.1111/j.1460-9568.2004.03514.x, 15233755.
38. Han JS. Acupuncture analgesia: areas of consensus and controversy. Pain 2011, 152(3 Suppl):S41-S48.
39. WHO Regional Office for the Western Pacific WHO Standard Acupuncture Point Locations in the Western Pacific Region 2009, Geneva, Switzerland: World Health Organization, WHO Regional Office for the Western Pacific.
40. Gear RW, Aley KO, Levine JD. Pain-induced analgesia mediated by mesolimbic reward circuits. J Neurosci 1999, 19(16):7175-7181.
41. Karczewski J, Spencer RH, Garsky VM, Liang A, Leitl MD, Cato MJ, Cook SP, Kane S, Urban MO. Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2. Br J Pharmacol 2010, 161(4):950-960. 10.1111/j.1476-5381.2010.00918.x, 2992907, 20860671.
42. Park JJ, Akazawa M, Ahn J, Beckman-Harned S, Lin FC, Lee K, Fine J, Davis RT, Langevin H. Acupuncture sensation during ultrasound guided acupuncture needling. Acupunct Med 2011, 29(4):257-265. 10.1136/aim.2010.003616, 21642648.
43. Ross MH, Kaye GI, Pawlina W. Connective Tissue Cells. Histology - A Text and Atlas: 4th Edition 2003, 141. Philadelphia: Lippincott Williams & Wilkins, Ross MH, Kaye GI, Pawlina W.
44. Jain A, Bronneke S, Kolbe L, Stab F, Wenck H, Neufang G. TRP-channel-specific cutaneous eicosanoid release patterns. Pain 2011, 152(12):2765-2772. 10.1016/j.pain.2011.08.025, 21962912.
45. Fiorillo C, Moro F, Brisca G, Astrea G, Nesti C, Bálint Z, Olschewski A, Meschini MC, Guelly C, Auer-Grumbach M, Battini R, Pedemonte M, Romano A, Menchise V, Biancheri R, Santorelli FM, Bruno C. TRPV4 mutations in children with congenital distal spinal muscular atrophy. Neurogenetics 2012, 13(3):195-203. 10.1007/s10048-012-0328-7, 22526352.
46. Adapala RK, Thoppil RJ, Luther DJ, Paruchuri S, Meszaros JG, Chilian WM, Thodeti CK. TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J Mol Cell Cardiol 2013, 54:45-52. 3935769, 23142541.
47. Kolker SJ, Walder RY, Usachev Y, Hillman J, Boyle DL, Firestein GS, Sluka KA. Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release. Ann Rheum Dis 2010, 69(5):903-909. 10.1136/ard.2009.117168, 3476728, 19933746.
48. Wei X. Expression of ASIC3 in Dural Fibroblasts: Implications for Headache Pathophysiology. Proceeding of the 2012 Frontiers in Biomedical Research - a Poster Forum: 7 Nov 2012; Arizona 2012, A54. Yan J, Navratilova E, Melemedjian O, Dussor G.
49. Ito N, Ruegg UT, Kudo A, Miyagoe-Suzuki Y, Takeda S. Capsaicin mimics mechanical load-induced intracellular signaling events: involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy. Channels 2013, 7(3):221-224. 10.4161/chan.24583, 3710350, 23584166.
50. Lotteau S, Ducreux S, Romestaing C, Legrand C, Van Coppenolle F. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle. PLoS One 2013, 8(3):e58673. 10.1371/journal.pone.0058673, 3594164, 23536811.
51. Pritschow BW, Lange T, Kasch J, Kunert-Keil C, Liedtke W, Brinkmeier H. Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue. Pflugers Arch 2011, 461(1):115-122. 10.1007/s00424-010-0883-4, 20924600.
52. Gitterman DP, Wilson J, Randall AD. Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line. J Physiol 2005, 562(Pt 3):759-769. 1665529, 15576453.
53. Langevin HM, Churchill DL, Cipolla MJ. Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture. FASEB J 2001, 15(12):2275-2282. 10.1096/fj.01-0015hyp, 11641255.
54. Langevin HM, Konofagou EE, Badger GJ, Churchill DL, Fox JR, Ophir J, Garra BS. Tissue displacements during acupuncture using ultrasound elastography techniques. Ultrasound Med Biol 2004, 30(9):1173-1183. 10.1016/j.ultrasmedbio.2004.07.010, 15550321.
55. Langevin HM, Yandow JA. Relationship of acupuncture points and meridians to connective tissue planes. Anat Rec 2002, 269(6):257-265. 10.1002/ar.10185, 12467083.
56. Kim KS, Nam YM. The analgesic effects of capsicum plaster at the Zusanli point after abdominal hysterectomy. Anesth Analg 2006, 103(3):709-713. 10.1213/01.ane.0000228864.74691.9f, 16931685.
57. Acar HV, Yilmaz A, Demir G, Gunal Eruyar S, Dikmen B. Capsicum plasters on acupoints decrease the incidence of emergence agitation in pediatric patients. Paediatr Anaesth 2012, doi:10.1111/j.1460-9592.2012.03876.x.
58. Kissin I. Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity. Anesth Analg 2008, 107(1):271-281. 10.1213/ane.0b013e318162cfa3, 2497455, 18635498.
59. Touska F, Marsakova L, Teisinger J, Vlachova V. A " cute" desensitization of TRPV1. Curr Pharm Biotechnol 2011, 12(1):122-129. 10.2174/138920111793937826, 20932251.
60. Lu GW. Characteristics of afferent fiber innervation on acupuncture points zusanli. Am J Physiol 1983, 245(4):R606-R612.
61. Wang SF, Chen YW, Shyu BC. The suppressive effect of electrical stimulation on nociceptive responses in the rat. Phys Ther 1997, 77(8):839-847.
62. Ferrini F, Salio C, Vergnano AM, Merighi A. Vanilloid receptor-1 (TRPV1)-dependent activation of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse. Pain 2007, 129(1-2):195-209.
63. Tambeli CH, Young A, Levine JD, Gear RW. Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation. Pain 2003, 106(1-2):173-179.
64. Tambeli CH, Parada CA, Levine JD, Gear RW. Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat. Eur J Neurosci 2002, 16(8):1547-1553. 10.1046/j.1460-9568.2002.02204.x, 12405969.
65. Tambeli CH, Levine JD, Gear RW. Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord. Pain 2009, 143(3):228-232. 10.1016/j.pain.2009.03.005, 2693265, 19375225.
66. Abraham TS, Chen ML, Ma SX. TRPV1 expression in acupuncture points: response to electroacupuncture stimulation. J Chem Neuroanat 2011, 41(3):129-136. 10.1016/j.jchemneu.2011.01.001, 3117662, 21256210.
67. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. J Pharmacol Exp Ther 2008, 324(3):1000-1010.
68. Rhee JS, Wang ZM, Nabekura J, Inoue K, Akaike N. ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapses. J Physiol 2000, 524(Pt 2):471-483. 2269889, 10766927.
69. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997, 389(6653):816-824. 10.1038/39807, 9349813.
70. Neelands TR, Jarvis MF, Han P, Faltynek CR, Surowy CS. Acidification of rat TRPV1 alters the kinetics of capsaicin responses. Mol Pain 2005, 1:28. 10.1186/1744-8069-1-28, 1266034, 16191202.
71. O'Neil RG, Heller S. The mechanosensitive nature of TRPV channels. Pflugers Arch 2005, 451(1):193-203. 10.1007/s00424-005-1424-4, 15909178.
72. Price MP, McIlwrath SL, Xie J, Cheng C, Qiao J, Tarr DE, Sluka KA, Brennan TJ, Lewin GR, Welsh MJ. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 2001, 32(6):1071-1083. 10.1016/S0896-6273(01)00547-5, 11754838.
73. Sipe WE, Brierley SM, Martin CM, Phillis BD, Cruz FB, Grady EF, Liedtke W, Cohen DM, Vanner S, Blackshaw LA, Bunnett NW. Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol 2008, 294(5):G1288-G1298. 10.1152/ajpgi.00002.2008, 18325985.
74. Buvinic S, Almarza G, Bustamante M, Casas M, Lopez J, Riquelme M, Saez JC, Huidobro-Toro JP, Jaimovich E. ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle. J Biol Chem 2009, 284(50):34490-34505. 10.1074/jbc.M109.057315, 2787310, 19822518.
75. Pinheiro AR, Paramos-de-Carvalho D, Certal M, Costa MA, Costa C, Magalhaes-Cardoso MT, Ferreirinha F, Sevigny J, Correia-de-Sa P. Histamine induces ATP release from human subcutaneous fibroblasts via pannexin-1 hemichannels leading to Ca2+ mobilization and cell proliferation. J Biol Chem 2013, in press.
76. Reinecke H, MacDonald GH, Hauschka SD, Murry CE. Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair. J Cell Biol 2000, 149(3):731-740. 10.1083/jcb.149.3.731, 2174851, 10791985.
77. Trovato-Salinaro A, Belluardo N, Frinchi M, von Maltzahn J, Willecke K, Condorelli DF, Mudo G. Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat. Am J Physiol Cell Physiol 2009, 296(3):C593-C606.
78. Langevin HM, Cornbrooks CJ, Taatjes DJ. Fibroblasts form a body-wide cellular network. Histochem Cell Biol 2004, 122(1):7-15.
79. Pistorio AL, Ehrlich HP. Modulatory effects of connexin-43 expression on gap junction intercellular communications with mast cells and fibroblasts. J Cell Biochem 2011, 112(5):1441-1449. 10.1002/jcb.23061, 3071433, 21328609.
80. Choi RC, Man ML, Ling KK, Ip NY, Simon J, Barnard EA, Tsim KW. Expression of the P2Y1 nucleotide receptor in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptor. J Neurosci 2001, 21(23):9224-9234.
81. Choi RC, Siow NL, Cheng AW, Ling KK, Tung EK, Simon J, Barnard EA, Tsim KW. ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control. J Neurosci 2003, 23(11):4445-4456.
82. Nakamura T, Iwanaga K, Murata T, Hori M, Ozaki H. ATP induces contraction mediated by the P2Y(2) receptor in rat intestinal subepithelial myofibroblasts. Eur J Pharmacol 2011, 657(1-3):152-158.
83. Homolya L, Watt WC, Lazarowski ER, Koller BH, Boucher RC. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice. J Biol Chem 1999, 274(37):26454-26460. 10.1074/jbc.274.37.26454, 10473605.
84. Mortensen SP, Nyberg M, Winding K, Saltin B. Lifelong physical activity preserves functional sympatholysis and purinergic signalling in the ageing human leg. J Physiol 2012, 590(Pt 23):6227-6236. 3530128, 22966164.
85. Bishnoi M, Premkumar LS. Possible consequences of blocking transient receptor potential vanilloid. Curr Pharm Biotechnol 2011, 12(1):102-114. 10.2174/138920111793937907, 20932252.
86. Xia R, Samad TA, Btesh J, Jiang LH, Kays I, Stjernborg L, Dekker N. TRPV1 signaling: mechanistic understanding and therapeutic potential. Curr Top Med Chem 2011, 11(17):2180-2191. 10.2174/156802611796904843, 21671876.
87. Materazzi S, Fusi C, Benemei S, Pedretti P, Patacchini R, Nilius B, Prenen J, Creminon C, Geppetti P, Nassini R. TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. Pflugers Arch 2012, 463(4):561-569. 10.1007/s00424-011-1071-x, 22258694.
88. Dube GR, Lehto SG, Breese NM, Baker SJ, Wang X, Matulenko MA, Honore P, Stewart AO, Moreland RB, Brioni JD. Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain 2005, 117(1-2):88-96.