The aggravation of clozapine-induced hepatotoxicity by glycyrrhetinic acid in rats

Journal of Pharmacological Sciences

Volumn 124, Issue 4, 2014, Pages 468-479

  Jia, Ling Ling ^a   Zhong, Ze Yu ^a   Li, Feng ^a   Ling, Zhao Li ^a   Chen, Yang ^a   Zhao, Wei Man ^a   Li, Ying ^a   Jiang, Shu Wen ^a   Xu, Ping ^a   Yang, Yang ^a   Hu, Meng Yue ^a   Liu, Li ^a   Liu, Xiao Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Clozapine; CYP1A2; CYP2C11; Glycyrrhetinic acid; Hepatotoxicity

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CLOZAPINE; CLOZAPINE N OXIDE; CYTOCHROME; CYTOCHROME P450 1A2; CYTOCHROME P450 2C11; CYTOCHROME P450 2C13; CYTOCHROME P450 2C19; GAMMA GLUTAMYLTRANSFERASE; GLYCYRRHETINIC ACID; MESSENGER RNA; NORCLOZAPINE; OMEPRAZOLE; PHENACETIN; TOLBUTAMIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; LIVER CELL CULTURE; LIVER MICROSOME; LIVER TOXICITY; LIVER WEIGHT; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROTEIN EXPRESSION; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CHOLESTEROL; CLOZAPINE; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES; DRUG SYNERGISM; GAMMA-GLUTAMYLTRANSFERASE; GLYCYRRHETINIC ACID; HEPATOCYTES; LIVER; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; STEROID 16-ALPHA-HYDROXYLASE; TRIGLYCERIDES;

EID: 84899519932     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13257FP     Document Type: Article

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