Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus

Drug Metabolism and Disposition

Volumn 40, Issue 6, 2012, Pages 1104-1112

  Liu, Haiyan ^a   Liu, Li ^a   Li, Jia ^a   Mei, Dan ^a   Duan, Ru ^a   Hu, Nan ^a   Guo, Haifang ^a   Zhong, Zeyu ^a   Liu, Xiaodong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 2C11; GLIBENCLAMIDE; ISOPHANE INSULIN; SULFAPHENAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXPOSURE; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; DRUG TRANSPORT; DRUG URINE LEVEL; ENZYME ACTIVITY; ENZYME DEFECT; INTESTINE PERFUSION; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; METABOLIC INHIBITION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STREPTOZOCIN DIABETES; TIME TO MAXIMUM PLASMA CONCENTRATION; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; ATP-BINDING CASSETTE TRANSPORTERS; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLYBURIDE; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; STEROID 16-ALPHA-HYDROXYLASE;

RATTUS;

EID: 84862113849     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.043513     Document Type: Article

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