Interspecies variability and drug interactions of clozapine metabolism by microsomes

Fundamental and Clinical Pharmacology

Volumn 13, Issue 5, 1999, Pages 577-581

  Bun, Hot ^a   Disdier, Béatrice ^a   Aubert, Claude ^a   Catalin, Jacques ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Clozapine; Drug interactions; Metabolism; Microsomes

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CEFTRIAXONE; CISPLATIN; CLOZAPINE; CYCLOPHOSPHAMIDE; DAUNORUBICIN; DILTIAZEM; ETOPOSIDE; FELODIPINE; IFOSFAMIDE; ISRADIPINE; KETOCONAZOLE; LACIDIPINE; MACROLIDE; MICONAZOLE; NICARDIPINE; NITRENDIPINE; PACLITAXEL; PENICILLIN DERIVATIVE; ROXITHROMYCIN; SULFONAMIDE; TENIPOSIDE; THIOTEPA; UNINDEXED DRUG; VINDESINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOG; DRUG DETERMINATION; DRUG METABOLISM; FEMALE; GUINEA PIG; HUMAN; LIVER MICROSOME METABOLISM; MALE; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

EID: 0033303953     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1999.tb00364.x     Document Type: Article

References (15)

1. Exchange of aromatically bound halogens for hydroxyl and methylthiogroups in metabolizing clozapine in man, Arzneim Forsch
2. Metabolism and bioactivation of clozapine by human liver in vitro
3. Clozapine for the treatment of resistant schizophrenics: A double-blind comparison with chlorpromazine
4. Pharmacokinetics and pharmacodynamics of clozapine
5. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: Evidence from a therapeutic drug monitoring service
6. Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate cytochrome P-450 reduced from rabbit liver microsomes
7. Microsomal enzymes involved in toxicology: Analysis and separation
8. Concentrations plasmatiques de la clozapine et de ses metabolites chez les patients schizophrenes resistants
9. A rapid and sensitive method for the quantification of microgram quantites of protein utilizing the principle of protein-dye binding
10. The carbon-monoxide binding pigment of liver microsomes
11. Ethoxyresorufin: Direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene
12. Ethoxy-, pentoxyl-and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450
13. P-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol
14. Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques
15. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine