메뉴 건너뛰기




Volumn 14, Issue 1, 2014, Pages

Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer

Author keywords

Colorectal cancer; Dna methylation; Hltf; Hpp1; Ldh; Neurog1

Indexed keywords

LACTATE DEHYDROGENASE; NEUROGENIN 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; HLTF PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; NEUROG1 PROTEIN, HUMAN; TMEFF2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR MARKER; TUMOR PROTEIN;

EID: 84899491319     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-245     Document Type: Article
Times cited : (50)

References (56)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • 10.1002/ijc.25516, 21351269
    • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127:2893-2917. 10.1002/ijc.25516, 21351269.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5    Parkin, D.M.6
  • 2
    • 6944230093 scopus 로고    scopus 로고
    • Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    • 10.1093/jnci/djh275, 15467030
    • O'Connell JB, Maggard MA, Ko CY. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 2004, 96:1420-1425. 10.1093/jnci/djh275, 15467030.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1420-1425
    • O'Connell, J.B.1    Maggard, M.A.2    Ko, C.Y.3
  • 3
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • 10.1016/j.cell.2007.01.029, 3894624, 17320506
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007, 128:683-692. 10.1016/j.cell.2007.01.029, 3894624, 17320506.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 4
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
    • 10.1038/nrc1799, 16491070
    • Baylin SB, Ohm JE. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat Rev Cancer 2006, 6:107-116. 10.1038/nrc1799, 16491070.
    • (2006) Nat Rev Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 6
    • 77349107376 scopus 로고    scopus 로고
    • DNA methylation markers in colorectal cancer
    • 10.1007/s10555-010-9207-6, 20135198
    • Kim MS, Lee J, Sidransky D. DNA methylation markers in colorectal cancer. Cancer Metastasis Rev 2010, 29:181-206. 10.1007/s10555-010-9207-6, 20135198.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 181-206
    • Kim, M.S.1    Lee, J.2    Sidransky, D.3
  • 7
    • 84860313256 scopus 로고    scopus 로고
    • Detection of DNA hypermethylation in remote media of patients with colorectal cancer: new biomarkers for colorectal carcinoma
    • 10.1007/s13277-012-0346-y, 22362383
    • Herbst A, Kolligs FT. Detection of DNA hypermethylation in remote media of patients with colorectal cancer: new biomarkers for colorectal carcinoma. Tumour Biol 2012, 33:297-305. 10.1007/s13277-012-0346-y, 22362383.
    • (2012) Tumour Biol , vol.33 , pp. 297-305
    • Herbst, A.1    Kolligs, F.T.2
  • 9
    • 13544257481 scopus 로고    scopus 로고
    • Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer
    • 10.1016/S1542-3565(04)00624-X, 15704048
    • Lenhard K, Bommer GT, Asutay S, Schauer R, Brabletz T, Göke B, Lamerz R, Kolligs FT. Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin Gastroenterol Hepatol 2005, 3:142-149. 10.1016/S1542-3565(04)00624-X, 15704048.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 142-149
    • Lenhard, K.1    Bommer, G.T.2    Asutay, S.3    Schauer, R.4    Brabletz, T.5    Göke, B.6    Lamerz, R.7    Kolligs, F.T.8
  • 10
    • 33846209151 scopus 로고    scopus 로고
    • Methylation of serum DNA is an independent prognostic marker in colorectal cancer
    • 10.1158/1078-0432.CCR-06-1264, 17189406
    • Wallner M, Herbst A, Behrens A, Crispin A, Stieber P, Göke B, Lamerz R, Kolligs FT. Methylation of serum DNA is an independent prognostic marker in colorectal cancer. Clin Cancer Res 2006, 12:7347-7352. 10.1158/1078-0432.CCR-06-1264, 17189406.
    • (2006) Clin Cancer Res , vol.12 , pp. 7347-7352
    • Wallner, M.1    Herbst, A.2    Behrens, A.3    Crispin, A.4    Stieber, P.5    Göke, B.6    Lamerz, R.7    Kolligs, F.T.8
  • 12
    • 84871908093 scopus 로고    scopus 로고
    • Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation
    • 10.1007/s00441-012-1454-0, 3508675, 22688958
    • Pan N, Kopecky B, Jahan I, Fritzsch B. Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation. Cell Tissue Res 2012, 349:415-432. 10.1007/s00441-012-1454-0, 3508675, 22688958.
    • (2012) Cell Tissue Res , vol.349 , pp. 415-432
    • Pan, N.1    Kopecky, B.2    Jahan, I.3    Fritzsch, B.4
  • 14
    • 33745500432 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
    • 10.1136/gut.2005.082933, 1856352, 16407376
    • Ogino S, Cantor M, Kawasaki T, Brahmandam M, Kirkner GJ, Weisenberger DJ, Campan M, Laird PW, Loda M, Fuchs CS. CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006, 55:1000-1006. 10.1136/gut.2005.082933, 1856352, 16407376.
    • (2006) Gut , vol.55 , pp. 1000-1006
    • Ogino, S.1    Cantor, M.2    Kawasaki, T.3    Brahmandam, M.4    Kirkner, G.J.5    Weisenberger, D.J.6    Campan, M.7    Laird, P.W.8    Loda, M.9    Fuchs, C.S.10
  • 15
    • 84862794149 scopus 로고    scopus 로고
    • Loss of HLTF function promotes intestinal carcinogenesis
    • 10.1186/1476-4598-11-18, 3337324, 22452792
    • Sandhu S, Wu X, Nabi Z, Rastegar M, Kung S, Mai S, Ding H. Loss of HLTF function promotes intestinal carcinogenesis. Mol Cancer 2012, 11:18. 10.1186/1476-4598-11-18, 3337324, 22452792.
    • (2012) Mol Cancer , vol.11 , pp. 18
    • Sandhu, S.1    Wu, X.2    Nabi, Z.3    Rastegar, M.4    Kung, S.5    Mai, S.6    Ding, H.7
  • 16
    • 39749110033 scopus 로고    scopus 로고
    • The helicase-like transcription factor and its implication in cancer progression
    • 10.1007/s00018-007-7392-4, 18034322
    • Debauve G, Capouillez A, Belayew A, Saussez S. The helicase-like transcription factor and its implication in cancer progression. Cell Mol Life Sci 2008, 65:591-604. 10.1007/s00018-007-7392-4, 18034322.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 591-604
    • Debauve, G.1    Capouillez, A.2    Belayew, A.3    Saussez, S.4
  • 19
    • 33845915676 scopus 로고    scopus 로고
    • Highly-methylated colorectal cancers show poorly-differentiated phenotype
    • Hibi K, Nakao A. Highly-methylated colorectal cancers show poorly-differentiated phenotype. Anticancer Res 2006, 26:4263-4266.
    • (2006) Anticancer Res , vol.26 , pp. 4263-4266
    • Hibi, K.1    Nakao, A.2
  • 21
    • 7044260844 scopus 로고    scopus 로고
    • Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study
    • 10.1373/clinchem.2004.039305, 15502094
    • Leung WK, To K-F, Man EPS, Chan MWY, Bai AHC, Hui AJ, Chan FKL, Lee JFY, Sung JJY. Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study. Clin Chem 2004, 50:2179-2182. 10.1373/clinchem.2004.039305, 15502094.
    • (2004) Clin Chem , vol.50 , pp. 2179-2182
    • Leung, W.K.1    To, K.-F.2    Man, E.P.S.3    Chan, M.W.Y.4    Bai, A.H.C.5    Hui, A.J.6    Chan, F.K.L.7    Lee, J.F.Y.8    Sung, J.J.Y.9
  • 22
    • 34247882544 scopus 로고    scopus 로고
    • Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps
    • 10.1111/j.1572-0241.2007.01108.x, 17378912
    • Leung WK, To K-F, Man EPS, Chan MWY, Hui AJ, Ng SSM, Lau JYW, Sung JJY. Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. Am J Gastroenterol 2007, 102:1070-1076. 10.1111/j.1572-0241.2007.01108.x, 17378912.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1070-1076
    • Leung, W.K.1    To, K.-F.2    Man, E.P.S.3    Chan, M.W.Y.4    Hui, A.J.5    Ng, S.S.M.6    Lau, J.Y.W.7    Sung, J.J.Y.8
  • 23
  • 24
    • 84865366657 scopus 로고    scopus 로고
    • Generation and characterization of Tmeff2 mutant mice
    • 10.1016/j.bbrc.2012.07.064, 3428475, 22828515
    • Chen TR, Wang P, Carroll LK, Zhang Y, Han B-X, Wang F. Generation and characterization of Tmeff2 mutant mice. Biochem Biophys Res Commun 2012, 425:189-194. 10.1016/j.bbrc.2012.07.064, 3428475, 22828515.
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 189-194
    • Chen, T.R.1    Wang, P.2    Carroll, L.K.3    Zhang, Y.4    Han, B.-X.5    Wang, F.6
  • 28
    • 80051539323 scopus 로고    scopus 로고
    • DNA methylation of colon mucosa in ulcerative colitis patients: Correlation with inflammatory status
    • 10.1002/ibd.21573, 21830274
    • Saito S, Kato J, Hiraoka S, Horii J, Suzuki H, Higashi R, Kaji E, Kondo Y, Yamamoto K. DNA methylation of colon mucosa in ulcerative colitis patients: Correlation with inflammatory status. Inflamm Bowel Dis 2011, 17:1955-1965. 10.1002/ibd.21573, 21830274.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1955-1965
    • Saito, S.1    Kato, J.2    Hiraoka, S.3    Horii, J.4    Suzuki, H.5    Higashi, R.6    Kaji, E.7    Kondo, Y.8    Yamamoto, K.9
  • 31
    • 39449101234 scopus 로고    scopus 로고
    • Methylation of the TPEF- and PAX6-promoters is increased in early bladder cancer and in normal mucosa adjacent to pTa tumours
    • 10.1111/j.1464-410X.2007.07322.x, 18070176
    • Hellwinkel OJC, Kedia M, Isbarn H, Budäus L, Friedrich MG. Methylation of the TPEF- and PAX6-promoters is increased in early bladder cancer and in normal mucosa adjacent to pTa tumours. BJU Int 2008, 101:753-757. 10.1111/j.1464-410X.2007.07322.x, 18070176.
    • (2008) BJU Int , vol.101 , pp. 753-757
    • Hellwinkel, O.J.C.1    Kedia, M.2    Isbarn, H.3    Budäus, L.4    Friedrich, M.G.5
  • 32
    • 84865332493 scopus 로고    scopus 로고
    • Methylation of TMEFF2 gene in tissue and serum DNA from patients with non-small cell lung cancer
    • 10.1007/s10059-012-0083-5, 3887809, 22814847
    • Lee SM, Park JY, Kim DS. Methylation of TMEFF2 gene in tissue and serum DNA from patients with non-small cell lung cancer. Mol Cells 2012, 34:171-176. 10.1007/s10059-012-0083-5, 3887809, 22814847.
    • (2012) Mol Cells , vol.34 , pp. 171-176
    • Lee, S.M.1    Park, J.Y.2    Kim, D.S.3
  • 33
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994, 269:23757-23763.
    • (1994) J Biol Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 34
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer
    • 10.1073/pnas.91.14.6496, 44229, 8022811
    • Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. Proc Natl Acad Sci U S A 1994, 91:6496-6500. 10.1073/pnas.91.14.6496, 44229, 8022811.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 35
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
    • 10.1074/jbc.270.36.21021, 7673128
    • Firth JD, Ebert BL, Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem 1995, 270:21021-21027. 10.1074/jbc.270.36.21021, 7673128.
    • (1995) J Biol Chem , vol.270 , pp. 21021-21027
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 36
    • 40949115368 scopus 로고    scopus 로고
    • Biology of HIF-1alpha
    • 10.1038/cdd.2008.12, 18259201
    • Weidemann A, Johnson RS. Biology of HIF-1alpha. Cell Death Differ 2008, 15:621-627. 10.1038/cdd.2008.12, 18259201.
    • (2008) Cell Death Differ , vol.15 , pp. 621-627
    • Weidemann, A.1    Johnson, R.S.2
  • 37
    • 0035370253 scopus 로고    scopus 로고
    • Activation of the HIF pathway in cancer
    • 10.1016/S0959-437X(00)00193-3, 11377966
    • Maxwell PH, Pugh CW, Ratcliffe PJ. Activation of the HIF pathway in cancer. Curr Opin Genet Dev 2001, 11:293-299. 10.1016/S0959-437X(00)00193-3, 11377966.
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 293-299
    • Maxwell, P.H.1    Pugh, C.W.2    Ratcliffe, P.J.3
  • 38
    • 84655161946 scopus 로고    scopus 로고
    • HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
    • Keith B, Johnson RS, Simon MC. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2012, 12:9-22.
    • (2012) Nat Rev Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 40
    • 77954659502 scopus 로고    scopus 로고
    • Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases
    • 10.1038/sj.bjc.6605737, 2906733, 20551951
    • Mekenkamp LJM, Koopman M, Teerenstra S, van Krieken JHJM, Mol L, Nagtegaal ID, Punt CJA. Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases. Br J Cancer 2010, 103:159-164. 10.1038/sj.bjc.6605737, 2906733, 20551951.
    • (2010) Br J Cancer , vol.103 , pp. 159-164
    • Mekenkamp, L.J.M.1    Koopman, M.2    Teerenstra, S.3    van Krieken, J.H.J.M.4    Mol, L.5    Nagtegaal, I.D.6    Punt, C.J.A.7
  • 42
    • 77956626185 scopus 로고    scopus 로고
    • Serological diagnostic factors for liver metastasis in patients with colorectal cancer
    • 10.3748/wjg.v16.i32.4084, 2928464, 20731024
    • Wu X, Ma F, Wang X-L. Serological diagnostic factors for liver metastasis in patients with colorectal cancer. World J Gastroenterol 2010, 16:4084-4088. 10.3748/wjg.v16.i32.4084, 2928464, 20731024.
    • (2010) World J Gastroenterol , vol.16 , pp. 4084-4088
    • Wu, X.1    Ma, F.2    Wang, X.-L.3
  • 43
    • 84857790397 scopus 로고    scopus 로고
    • Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients
    • 10.1038/bjc.2012.17, 3305976, 22315053
    • Scartozzi M, Giampieri R, Maccaroni E, Del Prete M, Faloppi L, Bianconi M, Galizia E, Loretelli C, Belvederesi L, Bittoni A, Cascinu S. Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients. Br J Cancer 2012, 106:799-804. 10.1038/bjc.2012.17, 3305976, 22315053.
    • (2012) Br J Cancer , vol.106 , pp. 799-804
    • Scartozzi, M.1    Giampieri, R.2    Maccaroni, E.3    Del Prete, M.4    Faloppi, L.5    Bianconi, M.6    Galizia, E.7    Loretelli, C.8    Belvederesi, L.9    Bittoni, A.10    Cascinu, S.11
  • 44
    • 0031037241 scopus 로고    scopus 로고
    • Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group
    • International Germ Cell Cancer Collaborative Group
    • International Germ Cell Cancer Collaborative Group Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 1997, 15:594-603. International Germ Cell Cancer Collaborative Group.
    • (1997) J Clin Oncol , vol.15 , pp. 594-603
  • 46
    • 0027444652 scopus 로고
    • A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project
    • A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med 1993, 329:987-994.
    • (1993) N Engl J Med , vol.329 , pp. 987-994
  • 47
    • 79956334386 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma
    • 10.1200/JCO.2010.29.4496, 21464406
    • Hecht JR, Trarbach T, Hainsworth JD, Major P, Jäger E, Wolff RA, Lloyd-Salvant K, Bodoky G, Pendergrass K, Berg W, Chen B-L, Jalava T, Meinhardt G, Laurent D, Lebwohl D, Kerr D. Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. J Clin Oncol 2011, 29:1997-2003. 10.1200/JCO.2010.29.4496, 21464406.
    • (2011) J Clin Oncol , vol.29 , pp. 1997-2003
    • Hecht, J.R.1    Trarbach, T.2    Hainsworth, J.D.3    Major, P.4    Jäger, E.5    Wolff, R.A.6    Lloyd-Salvant, K.7    Bodoky, G.8    Pendergrass, K.9    Berg, W.10    Chen, B.-L.11    Jalava, T.12    Meinhardt, G.13    Laurent, D.14    Lebwohl, D.15    Kerr, D.16
  • 48
    • 79956297102 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma
    • 10.1200/JCO.2010.29.5436, 21464401
    • Van Cutsem E, Bajetta E, Valle J, Köhne C-H, Randolph Hecht J, Moore M, Germond C, Berg W, Chen B-L, Jalava T, Lebwohl D, Meinhardt G, Laurent D, Lin E. Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma. J Clin Oncol 2011, 29:2004-2010. 10.1200/JCO.2010.29.5436, 21464401.
    • (2011) J Clin Oncol , vol.29 , pp. 2004-2010
    • Van Cutsem, E.1    Bajetta, E.2    Valle, J.3    Köhne, C.-H.4    Randolph Hecht, J.5    Moore, M.6    Germond, C.7    Berg, W.8    Chen, B.-L.9    Jalava, T.10    Lebwohl, D.11    Meinhardt, G.12    Laurent, D.13    Lin, E.14
  • 49
    • 77956467360 scopus 로고    scopus 로고
    • Cell-free DNA in the blood as a solid tumor biomarker-a critical appraisal of the literature
    • 10.1016/j.cca.2010.07.032, 20688053
    • Jung K, Fleischhacker M, Rabien A. Cell-free DNA in the blood as a solid tumor biomarker-a critical appraisal of the literature. Clin Chim Acta 2010, 411:1611-1624. 10.1016/j.cca.2010.07.032, 20688053.
    • (2010) Clin Chim Acta , vol.411 , pp. 1611-1624
    • Jung, K.1    Fleischhacker, M.2    Rabien, A.3
  • 50
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • 10.1038/nrc3066, 21562580
    • Schwarzenbach H, Hoon DSB, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011, 11:426-437. 10.1038/nrc3066, 21562580.
    • (2011) Nat Rev Cancer , vol.11 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.B.2    Pantel, K.3
  • 54
    • 0035205830 scopus 로고    scopus 로고
    • Prognostic factors in pancreatic carcinoma: serum LDH levels predict survival in metastatic disease
    • 10.1097/00000421-200112000-00003, 11801751
    • Tas F, Aykan F, Alici S, Kaytan E, Aydiner A, Topuz E. Prognostic factors in pancreatic carcinoma: serum LDH levels predict survival in metastatic disease. Am J Clin Oncol 2001, 24:547-550. 10.1097/00000421-200112000-00003, 11801751.
    • (2001) Am J Clin Oncol , vol.24 , pp. 547-550
    • Tas, F.1    Aykan, F.2    Alici, S.3    Kaytan, E.4    Aydiner, A.5    Topuz, E.6
  • 55
    • 78449307426 scopus 로고    scopus 로고
    • Tumor necrosis is a new promising prognostic factor in colorectal cancer
    • 10.1016/j.humpath.2010.04.018, 20869096
    • Pollheimer MJ, Kornprat P, Lindtner RA, Harbaum L, Schlemmer A, Rehak P, Langner C. Tumor necrosis is a new promising prognostic factor in colorectal cancer. Hum Pathol 2010, 41:1749-1757. 10.1016/j.humpath.2010.04.018, 20869096.
    • (2010) Hum Pathol , vol.41 , pp. 1749-1757
    • Pollheimer, M.J.1    Kornprat, P.2    Lindtner, R.A.3    Harbaum, L.4    Schlemmer, A.5    Rehak, P.6    Langner, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.