The adaptor TRAF5 limits the differentiation of inflammatory CD4 + T cells by antagonizing signaling via the receptor for IL-6

Nature Immunology

Volumn 15, Issue 5, 2014, Pages 449-456

  Nagashima, Hiroyuki ^a   Okuyama, Yuko ^a   Asao, Atsuko ^a   Kawabe, Takeshi ^a   Yamaki, Satoshi ^a   Nakano, Hiroyasu ^b,c   Croft, Michael ^d   Ishii, Naoto ^a   So, Takanori ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTIGENS, CD4; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINE RECEPTOR GP130; DISEASE PROGRESSION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTERLEUKIN-6; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS; TH17 CELLS; TNF RECEPTOR-ASSOCIATED FACTOR 5; TRANSCRIPTIONAL ACTIVATION;

EID: 84899477789     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2863     Document Type: Article

References (48)

1. Zhu J. Yamane H. &Paul W.E. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 28 445-489 (2010
2. Murphy K.M. &Reiner S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2 933-944 (2002
3. Hirano T. Interleukin 6 in autoimmune and inflammatory diseases: A personal memoir. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 86 717-730 (2010
4. Heinrich P.C. et al. Principles of interleukin (IL)-6-Type cytokine signalling and its regulation. Biochem. J. 374 1-20 (2003
5. Kishimoto T. Interleukin-6: From basic science to medicine-40 years in immunology. Annu. Rev. Immunol. 23 1-21 (2005
6. Zhou L. et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8 967-974 (2007
7. Ivanov I.I. et al. The orphan nuclear receptor ROR?t directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 1121-1133 (2006
8. Weaver C.T. Hatton R.D. Mangan P.R. &Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25 821-852 (2007
9. Korn T. Bettelli E. Oukka M. &Kuchroo V.K. IL-17 and Th17 cells. Annu. Rev. Immunol. 27 485-517 (2009
10. Diehl S. &Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol. Immunol. 39 531-536 (2002
11. Neurath M.F. &Finotto S. IL-6 signaling in autoimmunity chronic inflammation and inflammation-Associated cancer. Cytokine Growth Factor Rev. 22 83-89 (2011
12. Stritesky G.L. et al. The transcription factor STAT3 is required for T helper 2 cell development. Immunity 34 39-49 (2011
13. Hildebrand J.M. et al. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol. Rev. 244 55-74 (2011
14. Ha H. Han D. &Choi Y. in Current Protocols in Immunololgy (eds. Coligan J.E. Bierer B.E. Margulies D.H. Shevach E.M. &Strober W.) Ch. 11 Unit 11.9D 11.9D.1-11.9D.19 (John Wiley &Sons 2009
15. Häcker H. Tseng P.H. &Karin M. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat. Rev. Immunol. 11 457-468 (2011
16. Croft M. Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity? Nat. Rev. Immunol. 3 609-620 (2003
17. Sugamura K. Ishii N. &Weinberg A.D. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat. Rev. Immunol. 4 420-431 (2004
18. Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23 23-68 (2005
19. Kawai T. &Akira S. The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat. Immunol. 11 373-384 (2010
20. Sun L. Deng L. Ea C.K. Xia Z.P. &Chen Z.J. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14 289-301 (2004
21. Xie P. Kraus Z.J. Stunz L.L. Liu Y. &Bishop G.A. TNF receptor-Associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling. J. Immunol. 186 143-155 (2011
22. Tsitsikov E.N. et al. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity 15 647-657 (2001
23. Gardam S. Sierro F. Basten A. Mackay F. &Brink R. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28 391-401 (2008
24. King C.G. et al. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat. Med. 12 1088-1092 (2006
25. Kraus Z.J. Haring J.S. &Bishop G.A. TNF receptor-Associated factor 5 is required for optimal T cell expansion and survival in response to infection. J. Immunol. 181 7800-7809 (2008
26. Nakano H. et al. Targeted disruption of Traf5 gene causes defects in CD40- And CD27-mediated lymphocyte activation. Proc. Natl. Acad. Sci. USA 96 9803-9808 (1999
27. So T. Salek-Ardakani S. Nakano H. Ware C.F. &Croft M. TNF receptor-Associated factor 5 limits the induction of Th2 immune responses. J. Immunol. 172 4292-4297 (2004
28. Esparza E.M. Lindsten T. Stockhausen J.M. &Arch R.H. Tumor necrosis factor receptor (TNFR)-Associated factor 5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced TNFR in T cells. J. Biol. Chem. 281 8559-8564 (2006
29. Grech A. Quinn R. Srinivasan D. Badoux X. &Brink R. Complete structural characterisation of the mammalian and Drosophila TRAF genes: Implications for TRAF evolution and the role of RING finger splice variants. Mol. Immunol. 37 721-734 (2000
30. Tada K. et al. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-?B activation and protection from cell death. J. Biol. Chem. 276 36530-36534 (2001
31. Bettelli E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 235-238 (2006
32. Ye H. Park Y.C. Kreishman M. Kieff E. &Wu H. The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol. Cell 4 321-330 (1999
33. Park Y.C. Burkitt V. Villa A.R. Tong L. &Wu H. Structural basis for self-Association and receptor recognition of human TRAF2. Nature 398 533-538 (1999
34. Arch R.H. &Thompson C.B. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-Associated factors and activate nuclear factor ?B. Mol. Cell. Biol. 18 558-565 (1998
35. Serada S. et al. IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 105 9041-9046 (2008
36. Hirota K. et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat. Immunol. 12 255-263 (2011
37. Bulek K. et al. The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation. Nat. Immunol. 12 844-852 (2011
38. Sun D. et al. Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). Nat. Immunol. 12 853-860 (2011
39. Buchta C.M. &Bishop G.A. TRAF5 negatively regulates TLR signaling in B lymphocytes. J. Immunol. 192 145-150 (2014
40. Kawamata S. Hori T. Imura A. Takaori-Kondo A. &Uchiyama T. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-Associated factor (TRAF) 2- And TRAF5-mediated NF-?B activation. J. Biol. Chem. 273 5808-5814 (1998
41. Croft M. So T. Duan W. &Soroosh P. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229 173-191 (2009
42. Durant L. et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 32 605-615 (2010
43. Stahl N. et al. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267 1349-1353 (1995
44. Dittrich E. Haft C.R. Muys L. Heinrich P.C. &Graeve L. A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. J. Biol. Chem. 271 5487-5494 (1996
45. Tanaka Y. et al. c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130. Mol. Cell. Biol. 28 4805-4818 (2008
46. Mizushima S. &Nagata S. pEF-BOS a powerful mammalian expression vector. Nucleic Acids Res. 18 5322 (1990
47. Minami M. et al. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci. USA 93 3963-3966 (1996
48. Kitamura T. et al. Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics. Exp. Hematol. 31 1007-1014 (2003