메뉴 건너뛰기




Volumn 33, Issue 16, 2014, Pages 2098-2109

LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation

Author keywords

interleukin 6; LPLUNC1; nasopharyngeal carcinoma; signal transducer and activator of transcription 3; tumor associated macrophages

Indexed keywords

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84899456801     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.161     Document Type: Article
Times cited : (112)

References (55)
  • 2
    • 33646160623 scopus 로고    scopus 로고
    • Inflammation, a key event in cancer development
    • Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res 2006; 4: 221-233
    • (2006) Mol Cancer Res , vol.4 , pp. 221-233
    • Lu, H.1    Ouyang, W.2    Huang, C.3
  • 3
    • 84872598312 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Candido J, Hagemann T. Cancer-related inflammation. J Clin Immunol 2012; 33(Suppl 1): 79-84
    • (2012) J Clin Immunol , vol.33 , Issue.SUPPL. 1 , pp. 79-84
    • Candido, J.1    Hagemann, T.2
  • 4
    • 84857141296 scopus 로고    scopus 로고
    • Cancer-related inflammation: Common themes and therapeutic opportunities
    • Balkwill FR, Mantovani A. Cancer-related inflammation: Common themes and therapeutic opportunities. Semin Cancer Biol 2012; 22: 33-40
    • (2012) Semin Cancer Biol , vol.22 , pp. 33-40
    • Balkwill, F.R.1    Mantovani, A.2
  • 5
    • 35648983903 scopus 로고    scopus 로고
    • Inflammation and cancer: An ancient link with novel potentials
    • Hussain SP, Harris CC. Inflammation and cancer: An ancient link with novel potentials. Int J Cancer 2007; 121: 2373-2380
    • (2007) Int J Cancer , vol.121 , pp. 2373-2380
    • Hussain, S.P.1    Harris, C.C.2
  • 6
    • 33746040164 scopus 로고    scopus 로고
    • The inflammatory tumor microenvironment and its impact on cancer development
    • De Visser KE, Coussens LM. The inflammatory tumor microenvironment and its impact on cancer development. Contrib Microbiol 2006; 13: 118-137
    • (2006) Contrib Microbiol , vol.13 , pp. 118-137
    • De Visser, K.E.1    Coussens, L.M.2
  • 7
    • 58149231380 scopus 로고    scopus 로고
    • Cancer: Inflaming metastasis
    • Mantovani A. Cancer: Inflaming metastasis. Nature 2009; 457: 36-37
    • (2009) Nature , vol.457 , pp. 36-37
    • Mantovani, A.1
  • 8
    • 33748781182 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways
    • Yang Y, Zhou H, Li W, Zhou M, Zeng Z, Xiong W, et al. Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways. Mol Immunol 2007; 44: 984-992
    • (2007) Mol Immunol , vol.44 , pp. 984-992
    • Yang, Y.1    Zhou, H.2    Li, W.3    Zhou, M.4    Zeng, Z.5    Xiong, W.6
  • 9
    • 84857061006 scopus 로고    scopus 로고
    • Analysis of the contribution of nasopharyngeal epithelial cancer cells to the induction of a local inflammatory response
    • Liao Q, Guo X, Li X, Chen P, Liang F, Tang H, et al. Analysis of the contribution of nasopharyngeal epithelial cancer cells to the induction of a local inflammatory response. J Cancer Res Clin Oncol 2011; 138: 57-64
    • (2011) J Cancer Res Clin Oncol , vol.138 , pp. 57-64
    • Liao, Q.1    Guo, X.2    Li, X.3    Chen, P.4    Liang, F.5    Tang, H.6
  • 10
    • 34249338002 scopus 로고    scopus 로고
    • Tumor-Associated macrophage: Its role in cancer invasion and metastasis
    • Shih J, Yuan A, Chen JJW, Yang P. Tumor-Associated macrophage: Its role in cancer invasion and metastasis. J Cancer Mol 2006; 2: 6
    • (2006) J Cancer Mol , vol.2 , pp. 6
    • Shih, J.1    Yuan, A.2    Chen, J.J.W.3    Yang, P.4
  • 11
    • 84864585118 scopus 로고    scopus 로고
    • Tumor-Associated macrophages: From cancer supporters to tumoricidal effectors
    • Cocco C, Airoldi I. Tumor-Associated macrophages: From cancer supporters to tumoricidal effectors. Immunotherapy 2012; 4: 667-668
    • (2012) Immunotherapy , vol.4 , pp. 667-668
    • Cocco, C.1    Airoldi, I.2
  • 14
    • 77949345555 scopus 로고    scopus 로고
    • Tumor-Associated macrophages and survival in classic Hodgkin's lymphoma
    • Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, et al. Tumor-Associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med 2010; 362: 875-885
    • (2010) N Engl J Med , vol.362 , pp. 875-885
    • Steidl, C.1    Lee, T.2    Shah, S.P.3    Farinha, P.4    Han, G.5    Nayar, T.6
  • 15
    • 61949486981 scopus 로고    scopus 로고
    • Increased infiltration of tumor associated macrophages is associated with poor prognosis of bladder carcinoma in situ after intravesical bacillus Calmette-Guerin instillation
    • Takayama H, Nishimura K, Tsujimura A, Nakai Y, Nakayama M, Aozasa K, et al. Increased infiltration of tumor associated macrophages is associated with poor prognosis of bladder carcinoma in situ after intravesical bacillus Calmette-Guerin instillation. J Urol 2009; 181: 1894-1900
    • (2009) J Urol , vol.181 , pp. 1894-1900
    • Takayama, H.1    Nishimura, K.2    Tsujimura, A.3    Nakai, Y.4    Nakayama, M.5    Aozasa, K.6
  • 16
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-Associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas G, Germano G, Mantovani A, Allavena P. Tumor-Associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 2009; 86: 1065-1073
    • (2009) J Leukoc Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 18
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, et al. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 2009; 28: 2940-2947
    • (2009) Oncogene , vol.28 , pp. 2940-2947
    • Sullivan, N.J.1    Sasser, A.K.2    Axel, A.E.3    Vesuna, F.4    Raman, V.5    Ramirez, N.6
  • 19
    • 33749593039 scopus 로고    scopus 로고
    • Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-beta1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma
    • Tan EL, Selvaratnam G, Kananathan R, Sam CK. Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-beta1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma. BMC Cancer 2006; 6: 227
    • (2006) BMC Cancer , vol.6 , pp. 227
    • Tan, E.L.1    Selvaratnam, G.2    Kananathan, R.3    Sam, C.K.4
  • 20
    • 1542577667 scopus 로고    scopus 로고
    • The elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma
    • Chow KC, Chiou SH, Ho SP, Tsai MH, Chen CL, Wang LS, et al. The elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma. Oncol Rep 2003; 10: 813-819
    • (2003) Oncol Rep , vol.10 , pp. 813-819
    • Chow, K.C.1    Chiou, S.H.2    Ho, S.P.3    Tsai, M.H.4    Chen, C.L.5    Wang, L.S.6
  • 21
    • 77952169515 scopus 로고    scopus 로고
    • Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts
    • Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, et al. Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts. Histochem Cell Biol 2010; 133: 505-515
    • (2010) Histochem Cell Biol , vol.133 , pp. 505-515
    • Bingle, C.D.1    Wilson, K.2    Lunn, H.3    Barnes, F.A.4    High, A.S.5    Wallace, W.A.6
  • 22
    • 0037091061 scopus 로고    scopus 로고
    • PLUNC: A novel family of candidate host defence proteins expressed in the upper airways and nasopharynx
    • Bingle CD, Craven CJ. PLUNC: A novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet 2002; 11: 937-943
    • (2002) Hum Mol Genet , vol.11 , pp. 937-943
    • Bingle, C.D.1    Craven, C.J.2
  • 23
    • 79960880754 scopus 로고    scopus 로고
    • Distribution of human PLUNC/BPI fold-containing (BPIF) proteins
    • Bingle L, Bingle CD. Distribution of human PLUNC/BPI fold-containing (BPIF) proteins. Biochem Soc Trans 2011; 39: 1023-1027
    • (2011) Biochem Soc Trans , vol.39 , pp. 1023-1027
    • Bingle, L.1    Bingle, C.D.2
  • 25
    • 53149108232 scopus 로고    scopus 로고
    • Expression of PLUNC family members in benign and malignant salivary gland tumours
    • Vargas PA, Speight PM, Bingle CD, Barrett AW, Bingle L. Expression of PLUNC family members in benign and malignant salivary gland tumours. Oral Dis 2008; 14: 613-619
    • (2008) Oral Dis , vol.14 , pp. 613-619
    • Vargas, P.A.1    Speight, P.M.2    Bingle, C.D.3    Barrett, A.W.4    Bingle, L.5
  • 26
    • 0042021521 scopus 로고    scopus 로고
    • Identification of tissuespecific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray
    • Zhang B, Nie X, Xiao B, Xiang J, Shen S, Gong J, et al. Identification of tissuespecific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray. Genes Chromosomes Cancer 2003; 38: 80-90
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 80-90
    • Zhang, B.1    Nie, X.2    Xiao, B.3    Xiang, J.4    Shen, S.5    Gong, J.6
  • 27
    • 84855568783 scopus 로고    scopus 로고
    • Tumor cells and tumor-Associated macrophages: Secreted proteins as potential targets for therapy
    • Baay M, Brouwer A, Pauwels P, Peeters M, Lardon F. Tumor cells and tumor-Associated macrophages: Secreted proteins as potential targets for therapy. Clin Dev Immunol 2011; 2011: 565187
    • (2011) Clin Dev Immunol , vol.2011 , pp. 565187
    • Baay, M.1    Brouwer, A.2    Pauwels, P.3    Peeters, M.4    Lardon, F.5
  • 28
  • 30
    • 84864559929 scopus 로고    scopus 로고
    • Inflammation and cancer: New targets and novel therapeutic approach
    • Motilva V. Inflammation and cancer: New targets and novel therapeutic approach. Curr Pharm Des 2012; 18: 3829-3830
    • (2012) Curr Pharm Des , vol.18 , pp. 3829-3830
    • Motilva, V.1
  • 31
    • 84868131613 scopus 로고    scopus 로고
    • The role of tumor-Associated macrophage in tumor progression
    • Fukuda K, Kobayashi A, Watabe K. The role of tumor-Associated macrophage in tumor progression. Front Biosci (Schol Ed) 2012; 4: 787-798
    • (2012) Front Biosci (Schol Ed , vol.4 , pp. 787-798
    • Fukuda, K.1    Kobayashi, A.2    Watabe, K.3
  • 32
    • 47749155653 scopus 로고    scopus 로고
    • Cancer related inflammation: The macrophage connection
    • Sica A, Allavena P, Mantovani A. Cancer related inflammation: The macrophage connection. Cancer Lett 2008; 267: 204-215
    • (2008) Cancer Lett , vol.267 , pp. 204-215
    • Sica, A.1    Allavena, P.2    Mantovani, A.3
  • 33
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7: 211-217
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 34
    • 84655175066 scopus 로고    scopus 로고
    • Tumor-Associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma
    • Zhang BC, Gao J, Wang J, Rao ZG, Wang BC, Gao JF. Tumor-Associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma. Med Oncol 2010; 28: 1447-1452
    • (2010) Med Oncol , vol.28 , pp. 1447-1452
    • Zhang, B.C.1    Gao, J.2    Wang, J.3    Rao, Z.G.4    Wang, B.C.5    Gao, J.F.6
  • 35
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role of tumor-Associated macrophages
    • Allavena P, Sica A, Solinas G, Porta C, Mantovani A. The inflammatory micro-environment in tumor progression: The role of tumor-Associated macrophages. Crit Rev Oncol Hematol 2008; 66: 1-9
    • (2008) Crit Rev Oncol Hematol , vol.66 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 36
    • 80053640221 scopus 로고    scopus 로고
    • Tumor-Associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression
    • Wang R, Zhang J, Chen S, Lu M, Luo X, Yao S, et al. Tumor-Associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression. Lung Cancer 2011; 74: 188-196
    • (2011) Lung Cancer , vol.74 , pp. 188-196
    • Wang, R.1    Zhang, J.2    Chen, S.3    Lu, M.4    Luo, X.5    Yao, S.6
  • 37
    • 0034597340 scopus 로고    scopus 로고
    • Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern
    • Bingle CD, Bingle L. Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern. Biochim Biophys Acta 2000; 1493: 363-367
    • (2000) Biochim Biophys Acta , vol.1493 , pp. 363-367
    • Bingle, C.D.1    Bingle, L.2
  • 38
    • 0037428391 scopus 로고    scopus 로고
    • Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts
    • Di YP, Harper R, Zhao Y, Pahlavan N, Finkbeiner W, Wu R. Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem 2003; 278: 1165-1173
    • (2003) J Biol Chem , vol.278 , pp. 1165-1173
    • Di, Y.P.1    Harper, R.2    Zhao, Y.3    Pahlavan, N.4    Finkbeiner, W.5    Wu, R.6
  • 39
    • 84871254312 scopus 로고    scopus 로고
    • Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice
    • Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, et al. Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice. Cell Tissue Res 2012; 350: 455-464
    • (2012) Cell Tissue Res , vol.350 , pp. 455-464
    • Musa, M.1    Wilson, K.2    Sun, L.3    Mulay, A.4    Bingle, L.5    Marriott, H.M.6
  • 40
    • 53849117421 scopus 로고    scopus 로고
    • Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites
    • Canny G, Levy O. Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites. Trends Immunol 2008; 29: 541-547
    • (2008) Trends Immunol , vol.29 , pp. 541-547
    • Canny, G.1    Levy, O.2
  • 41
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002; 13: 357-368
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 42
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: Implications for Translational Therapeutics
    • Hong DS, Angelo LS, Kurzrock R. Interleukin-6 and its receptor in cancer: Implications for Translational Therapeutics. Cancer 2007; 110: 1911-1928
    • (2007) Cancer , vol.110 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3
  • 43
    • 0026689535 scopus 로고
    • Evidence for the involvement of interleukin 6 in experimental cancer cachexia
    • Strassmann G, Fong M, Kenney JS, Jacob CO. Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest 1992; 89: 1681-1684
    • (1992) J Clin Invest , vol.89 , pp. 1681-1684
    • Strassmann, G.1    Fong, M.2    Kenney, J.S.3    Jacob, C.O.4
  • 45
    • 84855472067 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway
    • Hsu HS, Lin JH, Hsu TW, Su K, Wang CW, Yang KY, et al. Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway. Lung Cancer 2012; 75: 167-177
    • (2012) Lung Cancer , vol.75 , pp. 167-177
    • Hsu, H.S.1    Lin, J.H.2    Hsu, T.W.3    Su, K.4    Wang, C.W.5    Yang, K.Y.6
  • 46
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer 2009; 9: 798-809
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 47
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine-40 years in immunology
    • Kishimoto T. Interleukin-6: From basic science to medicine-40 years in immunology. Annu Rev Immunol 2005; 23: 1-21
    • (2005) Annu Rev Immunol , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 48
    • 0035123574 scopus 로고    scopus 로고
    • Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors
    • Chen H, Lee JM, Zong Y, Borowitz M, Ng MH, Ambinder RF, et al. Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors. J Virol 2001; 75: 2929-2937
    • (2001) J Virol , vol.75 , pp. 2929-2937
    • Chen, H.1    Lee, J.M.2    Zong, Y.3    Borowitz, M.4    Ng, M.H.5    Ambinder, R.F.6
  • 49
    • 0041620205 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis
    • Hsiao JR, Jin YT, Tsai ST, Shiau AL, Wu CL, Su WC. Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. Br J Cancer 2003; 89: 344-349
    • (2003) Br J Cancer , vol.89 , pp. 344-349
    • Hsiao, J.R.1    Jin, Y.T.2    Tsai, S.T.3    Shiau, A.L.4    Wu, C.L.5    Su, W.C.6
  • 50
    • 77953155164 scopus 로고    scopus 로고
    • Chrysin suppresses IL-6-induced angiogenesis via down-regulation of JAK1/STAT3 and VEGF: An in vitro and in ovo approach
    • Lin CM, Shyu KG, Wang BW, Chang H, Chen YH, Chiu JH. Chrysin suppresses IL-6-induced angiogenesis via down-regulation of JAK1/STAT3 and VEGF: An in vitro and in ovo approach. J Agric Food Chem 2010; 58: 7082-7087
    • (2010) J Agric Food Chem , vol.58 , pp. 7082-7087
    • Lin, C.M.1    Shyu, K.G.2    Wang, B.W.3    Chang, H.4    Chen, Y.H.5    Chiu, J.H.6
  • 51
    • 67949089533 scopus 로고    scopus 로고
    • Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells
    • Kim SR, Bae MK, Kim JY, Wee HJ, Yoo MA, Bae SK. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochem Biophys Res Commun 2009; 387: 342-347
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 342-347
    • Kim, S.R.1    Bae, M.K.2    Kim, J.Y.3    Wee, H.J.4    Yoo, M.A.5    Bae, S.K.6
  • 52
    • 84875402648 scopus 로고    scopus 로고
    • Inhibition of the IL-6 signaling pathway: A strategy to combat chronic inflammatory diseases and cancer
    • Ataie-Kachoie P, Pourgholami MH, Morris DL. Inhibition of the IL-6 signaling pathway: A strategy to combat chronic inflammatory diseases and cancer. Cytokine Growth Factor Rev 2012; 24: 163-173
    • (2012) Cytokine Growth Factor Rev , vol.24 , pp. 163-173
    • Ataie-Kachoie, P.1    Pourgholami, M.H.2    Morris, D.L.3
  • 53
    • 33646125837 scopus 로고    scopus 로고
    • Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis
    • Fan SQ, Ma J, Zhou J, Xiong W, Xiao BY, Zhang WL, et al. Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis. Hum Pathol 2006; 37: 593-605
    • (2006) Hum Pathol , vol.37 , pp. 593-605
    • Fan, S.Q.1    Ma, J.2    Zhou, J.3    Xiong, W.4    Xiao, B.Y.5    Zhang, W.L.6
  • 54
    • 33847689914 scopus 로고    scopus 로고
    • Optimized THP-1 differentiation is required for the detection of responses to weak stimuli
    • Park EK, Jung HS, Yang HI, Yoo MC, Kim C, Kim KS. Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflamm Res 2007; 56: 45-50
    • (2007) Inflamm Res , vol.56 , pp. 45-50
    • Park, E.K.1    Jung, H.S.2    Yang, H.I.3    Yoo, M.C.4    Kim, C.5    Kim, K.S.6
  • 55
    • 79958161210 scopus 로고    scopus 로고
    • Deactivation of signal transducer and activator of transcription 3 reverses chemotherapeutics resistance of leukemia cells via down-regulating P-gp
    • Zhang X, Xiao W, Wang L, Tian Z, Zhang J. Deactivation of signal transducer and activator of transcription 3 reverses chemotherapeutics resistance of leukemia cells via down-regulating P-gp. PLoS One 2011; 6: E20965
    • (2011) PLoS One , vol.6
    • Zhang, X.1    Xiao, W.2    Wang, L.3    Tian, Z.4    Zhang, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.