The Role of tumor-associated macrophage in tumor progression

Frontiers in Bioscience - Scholar

Volumn 4 S, Issue 2, 2012, Pages 787-798

  Fukuda, Koji ^a   Kobayashi, Aya ^a   Watabe, Kounosuke ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Cancer stem cell; Cytokines; Inflammation; Monocytes; Review; Tumor associated macrophage

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE ANTIBODY; DOCETAXEL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10 RECEPTOR ANTIBODY; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEGA 3 FATTY ACID; PACLITAXEL; RANTES; ROQUINIMEX; TRABECTEDIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZOLEDRONIC ACID; CHEMOKINE;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CANCER INHIBITION; CANCER STEM CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL POLARITY; HUMAN; IMMUNOMODULATION; IMMUNOSTIMULATION; LYMPHANGIOGENESIS; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION; METASTASIS; MONOCYTE; NONHUMAN; PROSTATE CANCER; SOLID TUMOR; TARGET CELL DESTRUCTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR IMMUNITY; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; ANIMAL; DISEASE COURSE; IMMUNOLOGY; MACROPHAGE; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; REVIEW; VASCULARIZATION;

ANIMALS; CHEMOKINES; DISEASE PROGRESSION; HUMANS; MACROPHAGES; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 84868131613     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: None     Document Type: Article

References (98)

1. PS Steeg: Metastasis suppressors alter the signal transduction. Nat Rev Cancer 3, 55-63 (2003) (Pubitemid 37328887)
2. E. Lin, A. Nguyen, R. Russell, JW Pollard: Colonystimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193, 727-740 (2001)
3. L Bingle. NJ Brown, CE Lewis: The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 196, 254-265 (2002) (Pubitemid 34189413)
4. F Balkwill. KA Charles, A Mantovani: Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7, 211-217 (2005) (Pubitemid 40568680)
5. E. Lin, A. Nguyen, R. Russell, JW Pollard: Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193, 727-740 (2001)
6. JW Pollard: Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4, 71-78 (2004) (Pubitemid 38082155)
7. S. Stamatovic, R. Keep, S. Kunkel, AV Andjelkovic: Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J Cell Sci 116, 4615-4628 (2003) (Pubitemid 37461616)
8. B Bottazzi. N Polentarutti, R Acero. A Balsari, D Boraschi. P Ghezzi, M Salmona, A Mantovani: Regulation of the macrophage content of neoplasms by chemoattractants. Science 220, 210-212 (1983) (Pubitemid 13115270)
9. R. Negus, G. Stamp, M. Relf, F Burke. ST Malik, S Bernasconi. P Allavena, S Sozzani. A Mantovani, FR Balkwill: The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J. Clin. Invest 95, 2391-2396 (1995)
10. S. Hembruff, I Jokar. LYang, N Cheng: Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophagedependent and -independent mechanisms. Neoplasia 12, 425-433 (2010)
11. M. Colombo, A Mantovani: Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion. Cancer Res 65, 9113-9116 (2005) (Pubitemid 41507968)
12. F Balkwill: Cancer and the chemokine network. Nat Rev Cancer 4, 540-550 (2004) (Pubitemid 38868623)
13. P Allavena. A Sica, G Solinas. C Porta, A Mantovani: The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 66, 1-9 (2008) (Pubitemid 351324128)
14. S Aharinejad. P Paulus, M Sioud. M Hofmann, K Zins. R Schäfer, E. Stanley, D Abraham: Colonystimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Res 64, 5378-5384 (2004) (Pubitemid 39006559)
15. E. Lin, A. Nguyen, R. Russell, JW Pollard: Colonystimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193, 727-740 (2001)
16. A Nowicki. J Szenajch, G Ostrowska. A Wojtowicz, K Wojtowicz. AA Kruszewski, M Maruszynski. SL Aukerman, W Wiktor-Jedrzejczak,: Impaired tumor growth in colonystimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma. Int J Cancer 65, 112-119 (1996) (Pubitemid 26030942)
17. S Aharinejad. D Abraham, P Paulus. H Abri, M Hofmann. K Grossschmidt, R Schäferm. ER Stanley, R Hofbauer: Colony-stimulating factor-1 antisense treatment suppresses growth of human tumor xenografts in mice. Cancer Res 62, 5317-5324 (2002) (Pubitemid 35024608)
18. J. O'Shea, PJ Murray: Cytokine signaling modules in inflammatory responses. Immunity 28, 477-487 (2008) (Pubitemid 351467044)
19. F. Verreck, T d. Boer, D. Langenberg, M. Hoeve, M Kramer. E Vaisberg, R Kastelein. A Kolk, R d. Waal-Malefyt, TH Ottenhoff: Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria. Proc Natl Acad Sci USA 101, 4560-4565 (2004) (Pubitemid 38437450)
20. K Hiraoka. M Zenmyo, K Watari. H Iguchi, A Fotovati. YN Kimura, F Hosoi. T Shoda, K Nagata. H Osada, M Ono, M Kuwano: Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. Cancer Sci 99, 1595-1602 (2008)
21. S. Zeisberger, B Odermatt. C Marty, A. Zehnder-Fjällman, K Ballmer-Hofer, RA Schwendener: Clodronate-liposome-mediated depletion of tumour associated macrophages: a new and highly effective antiangiogenic therapy approach. Br J Cancer 95, 272-281 (2006) (Pubitemid 44187587)
22. A Mantovani. S Sozzani, M Locati. P Allavena, A Sica: Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23, 549-555 (2002) (Pubitemid 35223554)
23. S Gordon: Alternative activation of macrophages. Nat Rev Immunol 3, 23-35 (2003) (Pubitemid 37328697)
24. R. Himes, P. Burton, R. Kersey, GB Pierson: Brain tubulin polymerization in the absence of "microtubule-associated proteins". Proc Natl Acad Sci U S A 73, 4397-4399 (1976) (Pubitemid 8013983)
25. I. Lissbrant, P Stattin. P Wikstrom, J. Damber, L Egevad, A Bergh: Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival. Int J Oncol 17, 445-451 (2000)
26. A Mantovani. A Sica, S Sozzani. P Allavena, A Vecchi, M Locati: The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25, 677-86. (2004) (Pubitemid 39457982)
27. A. Filardy, D. Pires, M. Nunes, C. Takiya, C. Freire-de-Lima, F. Ribeiro-Gomes, GA Dos Reis: Proinflammatory clearance of apoptotic neutrophils induces an IL-12 (low) IL-10 (high) regulatory phenotype in macrophages. J Immunol 185, 2044-2050 (2010)
28. A Mantovani. A Sica, M Locati: Macrophage polarization comes of age. Immunity 23, 344-346 (2005) (Pubitemid 41443435)
29. P llavena. A Sica, G Solinas. C Porta, A Mantovani,: The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 66, 1-9 (2008) (Pubitemid 351324128)
30. S. Biswas, L Gangi. S Paul, T Schioppa. A Saccani, M Sironi. B Bottazzi, A Doni. B Vincenzo, F Pasqualini. L Vago, M Nebuloni. A Mantovani, A Sica: A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood 107, 2112-2122 (2006) (Pubitemid 43289397)
31. M Torroella-Kouri. R Silvera, D Rodriguez. R Caso, A Shatry. S Opiela, D Ilkovitch. RA Schwendener, V Iragavarapu-Charyulu. Y Cardentey, N Strbo, DM Lopez: Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Res 69, 4800-4809 (2009)
32. T Hagemann. J Wilson, F Burke. H Kulbe, N. Li, A Plüddemann. K Charles, S Gordon, FR Balkwill,: Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol 176, 5023-5032 (2006)
33. D. De Nardo, J. Barreto, P Andreu. L Vasquez, D Tawfik. N Kolhatkar, LM Coussens: CD4 (+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16, 91-102 (2009)
34. M. Dinapoli, C. Calderon, DM Lopez: The altered tumoricidal capacity of macrophages isolated from tumorbearing mice is related to reduce expression of the inducible nitric oxide synthase gene. J Exp Med 183, 1323-1329 (1996)
35. A. Klimp, H Hollema. C Kempinga, A. van der Zee, E. de Vries, T Daemen: Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages. Cancer Res 61, 7305-7359 (2001)
36. A Sica. A Saccani, B Bottazzi. N Polentarutti, A Vecchi. J van Damme, A Mantovani: Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages. J Immunol 164, 762-767 (2000) (Pubitemid 30043699)
37. A Saccani. T Schioppa, C Porta. SK Biswas, M Nebuloni. L Vago, B Bottazzi. MP Colombo, A Mantovani, A Sica: p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res 66, 11432-11440 (2006) (Pubitemid 46009975)
38. D. De Nardo, M Johansson, LM Coussens: Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev 27, 11-18 (2008)
39. A Mantovani. P Allavena, A Sica, F Balkwill: Cancerrelated inflammation. Nature 454, 436-444 (2008)
40. E Giraudo. M Inoue, D Hanahan: An aminobisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 114, 623-633 (2004) (Pubitemid 39578752)
41. T Krecicki. M Zalesska-Krecicka, M Jelen. T Szkudlarek, M Horobiowska: Expression of type IV collagen and matrix metalloproteinase-2 (type IV collagenase) in relation to nodal status in laryngeal cancer. Clin Otolaryngol 26, 469-472 (2001) (Pubitemid 34088250)
42. C Lewis, C Murdoch: Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 167, 627-635 (2005) (Pubitemid 41216349)
43. K. Talks, H Turley. KC Gatter, P. Maxwell, C. Pugh, P. Ratcliffe, AL Harris: The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157:411-421 (2000) (Pubitemid 30626905)
44. C Murdoch. A Giannoudis, CE Lewis: Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104, 2224-2234 (2004) (Pubitemid 39331817)
45. T Cramer. Y Yamanishi, B. Clausen, I Förster. R Pawlinski, N Mackman. VH Haase, R Jaenisch. M Corr, V Nizet. GS Firestein, H. Gerber, N Ferrara, RS Johnson: HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112, 645-657 (2003) (Pubitemid 36331777)
46. R. Bachelder, M. Wendt, AM Mercurio: Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 62, 7203-7206 (2002) (Pubitemid 36025239)
47. T Hanada. M Nakagawa, A Emoto. T Nomura, N Nasu, Y Nomura: Prognostic value of tumor-associated macrophage count in human bladder cancer. Int J Urol 7, 263-269 (2000) (Pubitemid 30440592)
48. S. Schoppmann, P Birner. J Stöckl, R Kalt. R Ullrich, C Caucig. E Kriehuber, K Nagy. K Alitalo, D Kerjaschki,: Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 161, 947-956 (2002) (Pubitemid 34988382)
49. RC Ji: Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics. Cancer Metastasis Rev 25, 677-694 (2006)
50. G Dranoff. E Jaffee, A Lazenby. P Golumbek, H Levitsky. K Brose, V Jackson. H Hamada, D Pardoll, RC Mulligan: Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A 90, 3539-3543 (1993) (Pubitemid 23111402)
51. H. Salvesen, LA Akslen: Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas. Int J Cancer 84, 538-543 (1999)
52. G Trinchieri, F Gerosa: Immunoregulation by interleukin-12. J Leukoc Biol 59, 505-511 (1996) (Pubitemid 26155295)
53. T Tsao. S Kornblau, S Safe. J. C Watt, V Ruvolo. W Chen, Y Qiu. K. R Coombes, Z Ju. M Abdelrahim, W Schober. X Ling, D Kardassis. C Meyer, A Schimmer. H Kantarjian, M Andreeff, M Konopleva: Role of peroxisome proliferatoractivated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Res 70, 4949-4960 (2010)
54. I Kryczek. L Zou, P Rodriguez. G Zhu, S Wei. P Mottram, M Brumlik. P Cheng, T Curiel. L Myers, A Lackner. X Alvarez, A Ochoa. L Chen, W Zou: B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 203, 871-881 (2006)
55. E Schutyser. S Struyf, P Proost. G Opdenakker, G Laureys. B Verhasselt, L Peperstraete. I Van de Putte, A Saccani. P Allavena, A Mantovani, J Van Damme: Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J Biol Chem 277, 24584-24593 (2002) (Pubitemid 34951986)
56. Z Sun. Z Yao, S Liu. H Tang, X Yan: An oligonucleotide decoy for Stat3 activates the immune response of macrophages to breast cancer. Immunobiology 211, 199-209 (2006) (Pubitemid 43337760)
57. A Toscani. RV Mettus, R Coupland. H Simpkins, J Litvin. J Orth, KS Hatton, and EP: Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature 387, 713-717 (1997) (Pubitemid 27193491)
58. E Schutyser. S Struyf, P Proost. G Opdenakker, G Laureys. B Verhasselt, L Peperstraete. I Van de Putte, A Saccani. P Allavena, A Mantovani, J Van Damme: Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J Biol Chem 277, 24584-24593 (2002) (Pubitemid 34951986)
59. M. J Rauh, L. Sly, J Kalesnikoff. MR Hughes, L. Cao, V Lam, G Krystal: The role of SHIP1 in macrophage programming and activation. Biochem Soc Trans 32, 785-788 (2004) (Pubitemid 39524379)
60. S. Robinson, K. Scott, J. Wilson, R. Thompson, A. Proudfoot, FR Balkwill: A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res 63, 8360-8365 (2003) (Pubitemid 37549490)
61. R Bonecchi. G Bianchi, P. Bordignon, D D'Ambrosio. R Lang, A Borsatti. S Sozzani, P Allavena. PA Gray, A Mantovani, F Sinigaglia: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187, 129-134 (1998) (Pubitemid 28044828)
62. T Hagemann. SC Robinson, M Schulz. L Trümper, F. Balkwill, C Binder: Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis 25, 1543-1549 (2004) (Pubitemid 39162720)
63. B Mytar. M Wołoszyn, R Szatanek. M Baj-Krzyworzeka, M Siedlar. I Ruggiero, J Wieckiewicz, M Zembala: Tumor cell-induced deactivation of human monocytes. J Leukoc Biol 74, 1094-1101 (2003) (Pubitemid 38040331)
64. S Hiratsuka. K Nakamura, S Iwai. M Murakami, T Itoh. H Kijima, J. Shipley, R. Senior, M Shibuya: MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2, 289-300 (2002) (Pubitemid 41043963)
65. T Hagemann. J Wilson, H Kulbe. NF Li, D. Leinster, K Charles. F Klemm, T Pukrop. C Binder, FR Balkwill: Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol 175, 1197-1205 (2005) (Pubitemid 41095008)
66. T Pukrop. F Klemm, T Hagemann. D Gradl, M Schulz. S Siemes, L Trümper, C Binder: Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci USA 103, 5454-5459 (2006)
67. J. Tjiu, J. Chen, C. Shun, S. Lin, Y. Liao, C. Chu, T. Tsai, H. Chiu, Y. Dai, Hnoue. P Yang, M. Kuo, SH Jee: Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction. J Invest Dermatol 129, 1016-1025 (2009)
68. R Giavazzi. A Garofalo, M. Bani, M Abbate. P Ghezzi, D Boraschi. A Mantovani, E Dejana: Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice. Cancer Res 50, 4771-4775 (1990) (Pubitemid 20230427)
69. S Goswami. E Sahai, J. Wyckoff, M Cammer. D Cox, F. Pixley, E. Stanley, J. Segall, JS Condeelis: Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res 65, 5278-5283 (2005) (Pubitemid 40827339)
70. J Wyckoff. W Wang, E. Lin, Y Wang. F Pixley, E. Stanley, T Graf. JW Pollard, J Segall, J Condeelis: A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res 64, 7022-7029 (2004) (Pubitemid 39331012)
71. J Fujimoto. H Sakaguchi, I Aoki, T Tamaya: Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers. Cancer Res 60, 2632-2635 (2000) (Pubitemid 30318237)
72. S Tsutsui. K Yasuda, K Suzuki. K Tahara, H Higashi, S Era: Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol Rep 14, 425-431 (2005)
73. L. Ailles, IL Weissman: Cancer stem cells in solid tumors. Curr Opin Biotechnol 18, 460-466 (2007) (Pubitemid 350116595)
74. S. Mani, W Guo. MJ Liao, E. Eaton, A Ayyanan. AY Zhou, M Brooks. F Reinhard, C. Zhang, M Shipitsin. LL Campbell, K Polyak. C Brisken, J Yang, RA Weinberg: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008) (Pubitemid 351636299)
75. C. Lin, C. Lin, K. Chen, J. Wu, S. Huang, SM Wang: Macrophage activation increases the invasive properties of hepatoma cells by destabilization of the adherens junction. FEBS Lett 580, 3042-3050 (2006) (Pubitemid 43729681)
76. J. Shih, A Yuan. JJ Chen, PC Yan: Tumor-Associated Macrophage: Its Role in Cancer Invasion and Metastasis. J Cancer 2, 101-106 (2006)
77. M Katoh, M Katoh: WNT Signaling Pathway and Stem Cell Signaling Network. Clin Cancer Res 13, 4042-4045 (2007) (Pubitemid 47105963)
78. N Barker, H Clevers: Leucine-rich repeat-containing Gproteincoupled receptors as markers of adult stem cells. Gastroenterology 138, 1681-1696 (2010)
79. T Pukrop. F Klemm, T Hagemann. D Gradl, M Schulz. S Siemes, L Trümper, C Binder: Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci USA 103, 5454-5459 (2006)
80. L. Ojalvo, C. Whittaker, J. Condeelis, JW Pollard,: Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol 184, 702-712 (2010)
81. N Takebe. PJ Harris, R. Warren, SP Ivy: Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 8, 97-106 (2011)
82. Y Fujiwara. Y Komohara, T Ikeda, M Takeya: Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer Sci 102, 206-211 (2011)
83. I Takanami. K Takeuchi, S Kodaira: Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: association with angiogenesis and poor prognosis. Oncology 57, 138-142 (1999) (Pubitemid 29385492)
84. K. Kerr, S. Johnson, G King. MM Kennedy, J Weir, R Jeffrey: Partial regression in primary carcinoma of the lung: does it occur? Histopathology 33, 55-63 (1998) (Pubitemid 28352572)
85. C Sessa. F De Braud, A Perotti. J Bauer, G Curigliano. C Noberasco, F Zanaboni. L Gianni, S Marsoni. J Jimeno, M D'Incalci. E Dall'ó, N Colombo: Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails. J Clin Oncol 23, 1867-1874 (2005) (Pubitemid 46211364)
86. P Allavena. M Signorelli, M Chieppa. E Erba, G Bianchi. F Marchesi, C. Olimpio, C Bonardi. A Garbi, A Lissoni. F de Braud, J Jimeno, M D'Incalci: Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res 65, 2964-2971 (2005) (Pubitemid 40490102)
87. S Rozel. CJ Galbán, K Nicolay. KC Lee, S Sud. C Neeley, L. Snyder, T. Chenevert, A Rehemtulla. BD Ross, KJ Pienta: Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model. J Cell Biochem 107, 58-64 (2009)
88. B Whitehurst. MJ Flister, J Bagaitkar. L Volk, C. Bivens, B Pickett. E Castro-Rivera, R. Brekken, R. Gerard, S Ran: Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor mode. Int J Cancer 121, 2181-2191 (2007) (Pubitemid 47585596)
89. PC Calder: Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids 75, 197-202 (2006) (Pubitemid 44292527)
90. L. Wahl, HK Kleinman,: Tumor-associated macrophages as targets for cancer therapy. J Natl Cancer Inst 90, 1583-1584 (1998) (Pubitemid 28523431)
91. E Giraudo. M Inoue, D Hanahan: An aminobisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 114, 623-633 (2004) (Pubitemid 39578752)
92. A Sica, V Bronte: Altered macrophage differentiation and immune dysfunction in tumor development. Clin Invest 117, 1155-1166 (2007) (Pubitemid 46718400)
93. A Mantovani, A Sica: Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 22, 231-237 (2010)
94. A Mantovani. P Allavena, A Sica, F Balkwill: Cancerrelated inflammation. Nature 24, 436-444 (2008)
95. T. Novak, T. Babcock, D. Jho, W. Helton, NJ Espat: NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am J Physiol Lung Cell Mol Physiol 284, 84-89 (2003)
96. C Guiducci. AP Vicari, S Sangaletti. G Trinchieri, MP Colombo: Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res 65, 3437-3446 (2005) (Pubitemid 40524630)
97. S. Robinson, K. Scott, J. Wilson, R. Thompson, A. Proudfoot, FR Balkwill: A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res 63, 8360-8365 (2003) (Pubitemid 37549490)
98. B Du. ZY Yang, X. Zhong, M Fang. YR Yan, G. Qi, YL Pan: Metastasis-associated protein1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer. World J Gastroenterol 17, 1219-1226 (2011)