LPLUNC1 modulates innate immune responses to vibrio cholerae

Journal of Infectious Diseases

Volumn 204, Issue 9, 2011, Pages 1349-1357

  Shin, Ok S ^a,b   Uddin, Taher ^f   Citorik, Robert ^a   Wang, Jennifer P ^e   Della Pelle, Patricia ^a   Kradin, Richard L ^a   Bingle, Colin D ^g   Bingle, Lynne ^h   Camilli, Andrew ^d   Bhuiyan, Taufiqur R ^f   Shirin, Tahmina ^f   Ryan, Edward T ^a,b   Calderwood, Stephen B ^a,b   Finberg, Robert W ^e   Qadri, Firdausi ^f   Larocque, Regina C ^a,b   Harris, Jason B ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Department of Medicine ^*  (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f ICDDRB Laboratory Sciences Division   (Bangladesh)

^g Department of Infection and Immunity   (United States)

^h UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LONG PALATE LUNG AND NASAL EPITHELIUM CLONE 1 PROTEIN; OUTER MEMBRANE PROTEIN; POLYMYXIN B; PROTEIN MD 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL GROWTH; BACTERIAL OUTER MEMBRANE; BACTERIAL STRAIN; CHOLERA; CONTROLLED STUDY; DOSE RESPONSE; DUODENUM BIOPSY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; INTESTINE MUCOSA; MEMBRANE VESICLE; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VIBRIO CHOLERAE;

DUODENUM; ESCHERICHIA COLI; HUMANS; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; PANETH CELLS; PROTEINS; VIBRIO CHOLERAE;

EID: 80053398939     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir544     Document Type: Article

References (36)

1. Cholera vaccines: WHO position paper. Wkly Epidemiol Rec 2010; 85: 117-28.
2. Nelson EJ, Harris JB, Morris JG Jr, Calderwood SB, Camilli A. Cholera transmission: the host, pathogen and bacteriophage dynamic. Nat Rev Microbiol 2009; 7:693-702.
3. Taylor RK, Miller VL, Furlong DB, Mekalanos JJ. Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. Proc Natl Acad Sci USA 1987; 84:2833-7. (Pubitemid 17064736)
4. Sack DA, Sack RB, Nair GB, Siddique AK. Cholera. Lancet 2004; 363: 223-33. (Pubitemid 38114723)
5. Qadri F, Bhuiyan TR, Dutta KK, et al. Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surface of the gut. Gut 2004; 53:62-9. (Pubitemid 38083012)
6. Mathan MM, Chandy G, Mathan VI. Ultrastructural changes in the upper small intestinal mucosa in patients with cholera. Gastroenterology 1995; 109:422-30.
7. Qadri F, Raqib R, Ahmed F, et al. Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139. Clin Diagn Lab Immunol 2002; 9:221-9. (Pubitemid 34226010)
8. Flach CF, Qadri F, Bhuiyan TR, et al. Broad up-regulation of innate defense factors during acute cholera. Infect Immun 2007; 75:2343-50. (Pubitemid 46744323)
9. LaRocque RC, Sabeti P, Duggal P, et al. A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population. Genes Immun 2009; 10(3);267-72.
10. Bingle CD, Gorr SU. Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family. Int J Biochem Cell Biol 2004; 36:2144-52. (Pubitemid 39094438)
11. Bingle CD, Wilson K, Lunn H, et al. Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts. Histochem Cell Biol 2010; 133:505-15.
12. Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999; 162:3749-52. (Pubitemid 29314747)
13. Wittmann I, Schonefeld M, Aichele D, Groer G, Gessner A, Schnare M. Murine bactericidal/permeability-increasing protein inhibits the endotoxic activity of lipopolysaccharide and gram-negative bacteria. J Immunol 2008; 180:7546-52.
14. Marra MN, Wilde CG, Collins MS, Snable JL, Thornton MB, Scott RW. The role of bactericidal/permeability-increasing protein as a natural inhibitor of bacterial endotoxin. J Immunol 1992; 148:532-7.
15. Canny G, Levy O. Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites. Trends Immunol 2008; 29:541-7.
16. Wilde CG, Seilhamer JJ, McGrogan M, et al. Bactericidal/ permeabilityincreasing protein and lipopolysaccharide (LPS)-binding protein: LPS binding properties and effects on LPS-mediated cell activation. J Biol Chem 1994; 269:17411-6.
17. Qadri F, Ahmed F, Karim MM, et al. Lipopolysaccharide-and cholera toxin-specific subclass distribution of B-cell responses in cholera. Clin Diagn Lab Immunol 1999; 6:812-8. (Pubitemid 29529971)
18. Bishop AL, Schild S, Patimalla B, Klein B, Camilli A. Mucosal immunization with Vibrio cholerae outer membrane vesicles provides maternal protection mediated by antilipopolysaccharide antibodies that inhibit bacterial motility. Infect Immun 2010; 78:4402-20.
19. Latz E, Visintin A, Lien E, et al. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem 2002; 277:47834-43. (Pubitemid 36159310)
20. Zhou S, Cerny AM, Bowen G, et al. Discovery of a novel TLR2 signaling inhibitor with anti-viral activity. Antiviral Res 2010; 87:295-306.
21. Kurt-Jones EA, Popova L, Kwinn L, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000; 1:398-401.
22. Matson JS, Yoo HJ, Hakansson K, Dirita VJ. Polymyxin B resistance in El Tor Vibrio cholerae requires lipid acylation catalyzed by MsbB. J Bacteriol 2010; 192:2044-52.
23. Harrison LM, Rallabhandi P, Michalski J, et al. Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kappaB activation. Infect Immun 2008; 76:5524-34.
24. Hou J, Yashiro K, Okazaki Y, Saijoh Y, Hayashizaki Y, Hamada H. Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily. Dev Dyn 2004; 229:373-9. (Pubitemid 38140477)
25. LeClair EE, Nomellini V, Bahena M, et al. Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium. Genomics 2004; 83:658-66. (Pubitemid 38340807)
26. Bingle CD, LeClair EE, Havard S, Bingle L, Gillingham P, Craven CJ. Phylogenetic and evolutionary analysis of the PLUNC gene family. Protein Sci 2004; 13:422-30. (Pubitemid 38124963)
27. Wheeler TT, Haigh BJ, McCracken JY, Wilkins RJ, Morris CA, Grigor MR. The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor salivary gland protein are members of the PSP/LBP superfamily of proteins. Biochim Biophys Acta 2002; 1579:92-100. (Pubitemid 35341431)
28. Bingle CD, Craven CJ. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet 2002; 11:937-43. (Pubitemid 34449781)
29. Gazzano-Santoro H, Parent JB, Grinna L, et al. High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide. Infect Immun 1992; 60:4754-61.
30. Iovine NM, Elsbach P, Weiss J. An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N-and C-terminal domains. Proc Natl Acad Sci USA 1997; 94:10973-8.
31. Marra MN, Wilde CG, Griffith JE, Snable JL, Scott RW. Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. J Immunol 1990; 144:662-6. (Pubitemid 20036099)
32. UddinT, Harris JB,BhuiyanTR, et al.Mucosal immunologic responses in cholera patients in Bangladesh. Clin Vaccine Immunol 2011; 18:506-12.
33. Bandyopadhaya A, Sarkar M, Chaudhuri K. IL-1beta expression in Int407 is induced by flagellin of Vibrio cholerae through TLR5 mediated pathway. Microb Pathog 2008; 44:524-36.
34. Toma C, Higa N, Koizumi Y, et al. Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. J Immunol 2010; 184:5287-97.
35. Yoon SS, Mekalanos JJ. Decreased potency of the Vibrio cholerae sheathed flagellumto trigger host innate immunity. Infect Immun 2008; 76:1282-8. (Pubitemid 351428092)
36. Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 2000; 1:113-8.