Multiple cell culture factors can affect the glycosylation of Asn-184 in CHO-produced tissue-type plasminogen activator

Biotechnology and Bioengineering

Volumn 70, Issue 1, 2000, Pages 25-31

  Andersen, Dana C ^a   Bridges, Tiffany ^a   Gawlitzek, Martin ^a   Hoy, Cynthia ^a  

^a GENENTECH INC   (United States)

Author keywords

Cell culture; Cell cycle; Chinese hamster ovary (CHO); Glycosylation; Site occupancy; Tissue type plasminogen activator

Indexed keywords

CHEMICAL BONDS; OLIGOMERS; POLYSACCHARIDES; THERMAL EFFECTS; TISSUE CULTURE;

BUTYRATE; GLYCOSYLATION; OLIGOSACCHARIDE;

ANIMAL CELL CULTURE;

AMINO ACID; ASPARAGINE; BUTYRIC ACID; CARBOHYDRATE; GLYCOPROTEIN; OLIGOSACCHARIDE; QUINIDINE; RECOMBINANT PROTEIN; THYMIDINE; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL FRACTIONATION; CHO CELL; CONTROLLED STUDY; FIBRIN FORMATION; GROWTH RATE; NONHUMAN; PROTEIN GLYCOSYLATION; TEMPERATURE;

ANIMAL; ASPARAGINE; BUTYRATES; CELL CULTURE; CELL CYCLE; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSYLATION; HAMSTERS; HUMAN; OLIGOSACCHARIDES; PLASMINOGEN ACTIVATORS; QUINIDINE; RECOMBINANT PROTEINS; TEMPERATURE; THYMIDINE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0034610095     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0290(20001005)70:1<25::AID-BIT4>3.0.CO;2-Q     Document Type: Article

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