Hypoxia/oxidative stress alters the pharmacokinetics of CPU86017-RS through mitochondrial dysfunction and NADPH oxidase activation

Acta Pharmacologica Sinica

Volumn 34, Issue 12, 2013, Pages 1575-1584

  Gao, Jie ^a   Ding, Xuan Sheng ^a   Zhang, Yu Mao ^a   Dai, De Zai ^a   Liu, Mei ^a   Zhang, Can ^a   Dai, Yin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antiarrhythmic agents; Apocynin; CPU86017 RS; ER stress; Hypoxia; Isoproterenol; Mitochondria; N acetylcysteine; NADPH oxidase; Pharmacokinetics

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 6; ANTIARRHYTHMIC AGENT; APOCYNIN; ASCORBIC ACID; CPU 86017 RS; CPU 86017RS; ISOPRENALINE; MANGANESE SUPEROXIDE DISMUTASE; NITROGEN; PRK LIKE ER KINASE; PROTEIN; PROTEIN PERK; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; CPU86017 RS; CPU86017-RS; FUSED HETEROCYCLIC RINGS;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; DRUG METABOLISM; DRUG TISSUE LEVEL; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; IN VITRO STUDY; INTERMITTENT HYPOXIA; LIVER MICROSOME; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TISSUE DISTRIBUTION; TREATMENT DURATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; DOSE RESPONSE; ENZYMOLOGY; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HALF-LIFE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MALE; MICROSOMES, LIVER; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84899128523     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.94     Document Type: Article

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