Effects of L-malate on mitochondrial oxidoreductases in liver of aged rats

Physiological Research

Volumn 60, Issue 2, 2011, Pages 329-336

  Wu, J L ^a   Wu, Q P ^a   Peng, Y P ^b   Zhang, J M ^a  

^a GUANGDONG INSTITUTE OF MICROBIOLOGY   (China)

^b SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Aging; Electron transport chain; L malate; Mitochondria

Indexed keywords

EID: 79959265962     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: 10.33549/physiolres.931986     Document Type: Article

References (42)

1. ARIVAZHAGAN P, RAMANATHAN K, PANNEERSELVAM C: Effect of DL-a-lipoic acid on mitochondrial enzymes in aged rats. Chem Biol Interact 138: 189-198, 2001.
2. BECKMAN KB, AMES BN: The free radical theory of aging matures. Physiol Rev 78: 547-581, 1998.
3. BENDAHAN D, MATTEI JP, GHATTAS B, CONFORT-GOUNY S, LE GUERN ME, COZZONE PJ: Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med 36: 282-289, 2002.
4. BIRCH-MACHIN MA, BRIGGS HL, SABORIDO AA, BINDOFF LA, TURNBULL DM: An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria. Biochem Med Metab Biol 51: 35-42, 1994.
5. BOBYLEVA-GUARRIERO B, LARDY HA: The role of malate in exercise-induced enhancement of mitochondrial respiration. Arch Biochem Biophys 245: 270-276, 1986.
6. BRADFORD MM: A rapid and sensitive method for the quantization of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
7. ČERVINKOVÁ Z, KŘIVÁKOVÁ P, LÁBAJOVÁ A, ROUŠAR T, LOTKOVÁ H, KUČERA O, ENDLICHER R, ČERVINKA M, DRAHOTA Z: Mechanisms participating in oxidative damage of isolated rat hepatocytes. Arch Toxicol 83: 363-372, 2009.
8. CHANCE B, SIES H, BOVERIS A: Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527-605, 1979.
9. CHAPPEL JB: Systems used for the transport of substrates into mitochondria. Br Med Bull 24: 150-157, 1968.
10. CORTOPASSI GA, SHIBATA D, SOONG NW, ARNHEIM N: A pattern of accumulation of somatic deletion of mitochondrial DNA in aging tissue. Proc Natl Acad Sci USA 89: 7370-7374, 1992.
11. DREW B, LEEUWENBRUGH C: Aging and the role of reactive nitrogen species. Ann N Y Acad Sci 959: 66-81, 2002.
12. DROUET M, LAUTHIER F, CHARMES JP, SAUVAGE P, RATINAND MH: Age associated changes in mitochondrial parameters on peripheral human lymphocytes. Exp Gerontol 34: 69-78, 1999.
13. ENDLICHER R, KŘIVÁKOVÁ P, RAUCHOVÁ H, NUSKOVÁ H, ČERVINKOVÁ Z, DRAHOTA Z: Peroxidative damage of mitochondrial respiration is substrate-dependent. Physiol Res 58: 685-692, 2009.
14. FERGUSON M, MOCHETT RJ, SHEN Y, ORR WC, SOHAL RS: Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Biochem J 390: 501-511, 2005.
15. FERGUSON SMF, WILLIAMS GR: The Effect of malate and other dicarboxylic acids on mitochondrial isocitrate metabolism. J Biol Chem 241: 3696-3700, 1966.
16. FERNANDEZ-CHECA JC, YI J, GARCIARUIZ C, OKHTENS M, KAPLOWITZ N: Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis 16: 147-158, 1996.
17. GARCIA-RUIZ C, COLELL A, MORALES A, KAPLOWITZ N, FERNANDEZ-CHECA JC: Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 48: 825-834, 1995.
18. HAGEN TM, LIU J, LYKKESFELDT J, WEHR CM, INGERSOLL RT, VINARSKY V, BARTHOLOMEW JC, AMES BN: Feeding acetyl-Lcarnitine and lipoic acid to old rat significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA 99: 1870-1875, 2002.
19. HAGEN TM, YOWE DL, BARTHOLOMEW JC, WHER CM, DO KL, PARK JY, AMES BN: Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci USA 94: 3064-3069, 1997.
20. HARMAN D: Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 340-351, 1956.
21. HARMAN D: The biological clock: the mitochondria? J Am Geriatr Soc 20: 145-147, 1972
22. HOCH FL: Cardiolipins and biomembrane function. Biochim Biophys Acta 1113: 71-133, 1992.
23. JOHNSON LV, WALSH ML, CHEN LB: Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acad Sci USA 77: 990-994, 1980.
24. KALAISELVI T, PANNEERSELVAM C: Effect of l-carnitine on the status of lipid peroxidation and antioxidants in aging rats. J Nutr Biochem 9: 575-581, 1998.
25. KWONG LK, SOHAL RS: Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria. Arch Biochem Biophys 350: 118-126, 1998.
26. KWONG LK, SOHAL RS: Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse. Arch Biochem Biophys 373: 16-22, 2000.
27. MECOCCI P, BEAL MF, CECCHETTI R, POLIDORI MC, CHERUBINI A, CHIONNE F, AVELLINI L, ROMANO G, SENIN U: Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol Chem Neuropathol 31: 53-64, 1997.
28. MIQUEL J, ECONOMOS AC, FLEMING J, JOHNSON JE JR: Mitochondrial role in cell aging. Exp Gerontol 15: 575-591, 1980.
29. MULLER-HOCKER J, AUST D, ROHRBACH H, NAPIWOTZKY J, REITH A, LINK TA, SEIBEL P, HOLZEL D, HADENBACH B: Defects of the respiratory chain in the normal human liver and in cirrhosis during aging. Hepatology 26: 709-719, 1997.
30. OZAWA T: Genetic and functional changes in mitochondria associated with aging. Physiol Rev 77: 425-464, 1997.
31. PARADIES G, PETROSILLO G, PISTOLESE M, RUGGIERO FM: The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS Lett 466: 323-326, 2000.
32. SANDHU SK, KAUR G: Mitochondrial electron transport chain complexes in aging rat brain and lymphocytes Biogerontology 4: 19-29, 2003
33. SAVITHA S, SIVARAJAN K, HARIPRIYA D, KOKILAVANI V, PANNEERSELVAM C: Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr 24: 794-800, 2005.
34. SCHOLZ TD, TENEYCK CJ, SCHUTTE BC: Thyroid hormone regulation of the NADH shuttles in liver and cardiac mitochondria. J Mol Cell Cardiol 32: 1-10, 2000.
35. SHIGENAGA MK, HAGEN TM, AMES BN: Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 91: 10771-10778, 1994.
36. SMITH JA, WEIDEMANN MJ: Further characterization of the neutrophil oxidative burst by flow cytometry. J Immunol Methods 162: 261-268, 1993.
37. SOHAL RS, DUBEY A: Mitochondrial oxidative damage, hydrogen peroxide release and aging. Free Radic Biol Med 16: 621-626, 1994.
38. SOHAL RS, SOHAL BH: Hydrogen peroxide release by mitochondria increases during aging. Mech Ageing Dev 57: 187-202, 1991.
39. RICHTER C, GOGVADZE V, LAFFRANCHI R, SCHLAPBACH R, SCHWEIZER M, SUTER M, WALTER P, YAFFEE M: Oxidants in mitochondria: from physiology to disease. Biochim Biophys Acta 1271: 67-74, 1995.
40. TROUNCE I, BYRNE E, MARZUKI S: Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing. Lancet 8639: 637-639, 1989.
41. WU JL WU QP, HUANG JM, CHEN RY, CAI M, TAN JB: Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice. Physiol Res 56: 213-220, 2007.
42. WU JL, WU QP, YANG XF, WEI MK, ZHANG JM, HUANG Q, ZHOU XY: L-malate reverses oxidative stress and antioxidative defenses in liver and heart of aged rats. Physiol Res 57: 261-268, 2008.