Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver

Drug Metabolism and Disposition

Volumn 35, Issue 5, 2007, Pages 765-771

  Fradette, Caroline ^a   Batonga, Joëlle ^a   Teng, Shirley ^b   Piquette Miller, Micheline ^b   Du Souich, Patrick ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B4; CYTOCHROME P450 2C; CYTOCHROME P450 2C16; CYTOCHROME P450 2C5; CYTOCHROME P450 3A; CYTOCHROME P450 3A6; GAMMA INTERFERON; GLYCOPROTEIN P; INTERLEUKIN 1BETA; INTERLEUKIN 2; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING; CONTROLLED STUDY; DOWN REGULATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; IMMUNOBLOTTING; INCUBATION TIME; LIVER CELL; MALE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE DISEASE; ANIMALS; ANOXIA; ARYL HYDROCARBON HYDROXYLASES; CELL HYPOXIA; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; DOWN-REGULATION; HEPATOCYTES; IMMUNOBLOTTING; ISOENZYMES; LIVER; MALE; MODELS, ANIMAL; OXYGEN; OXYGEN CONSUMPTION; P-GLYCOPROTEIN; RABBITS; RECEPTORS, STEROID; RNA, MESSENGER; UP-REGULATION;

ANIMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 34247359571     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.013508     Document Type: Article

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