Monoclonal antibodies: The story of a discovery that revolutionized scienceand medicine

Nature Reviews Immunology

Volumn 4, Issue 2, 2004, Pages 153-156

  Alkan, Sefik S ^a  

^a 3M COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY;

ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; CELL FUSION; MEDICAL RESEARCH; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS;

ANTIBODIES, MONOCLONAL; CELL FUSION; HISTORY, 20TH CENTURY; NOBEL PRIZE;

EID: 85047696843     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri1265     Document Type: Article

References (19)

1. Köhler, G. and Milstein, C. Continuous cultures of fused cells secreting antibodies of predefined specificity.Nature256, 495-497 (1975).
2. Silverstein, A. M. inFundamentalImmunology.3rd edn (ed. Paul, W. E) 21-41 (Raven Press, New York, 1993).
3. Janeway, Cet al.Immunobiology. (Garland Publishers, 2001).
4. Jerne, N. K. The natural-selection theory of antibody formation.Proc. NatlAcad. Sci. USA41, 849-857(1955).
5. Burnet, F. M., Immunological recognition of self. Nobel lecture, 589-701 (12 December 1960).
6. Tonegawa, S., Somatic generation of immune diversity. Nobel lecture, 381-405 (8 December 1987).
7. Jerne, N. K. andNordin, A. A. Plaque formation in agar by single antibody producing cells.Science140, 405(1963).
8. Jerne, N. K. The generative grammar of the immune system. Nobel lecture, 211-225 (8 December 1984).
9. Milstein, C., From the structure of antibodies to thediversification of the immune response. Nobel lecture, 248-270 (8 December 1984).
10. Köhler, G., Derivation and diversification of monoclonal antibodies. Nobel lecture, 228-243 (8 December 1984).
11. Alkan, S. S. and Braun, D. G. InSynthetic Peptides asAntigens.264-278 (Ciba Foundation, Wiley, Chichester, 1986).
12. Asselbergs, F.et al.Localization of peptides recognized by monoclonal antibodies on tissue-type and urokinase-typeplasminogen activators using recombinant hybridenzymes.Fibrinolysis7, 1-14 (1993).
13. Alkan, S. S.et al.Estimation of heterokaryon formation and hybridoma growth in murine and human cell fusions.Hybridoma6, 371-379 (1987).
14. Monoclonal Antibody-Based Diagnostics.Global Industry Analysts, 1998.
15. Antibody Engineering, special edition, J. Immunol.Methods231(1999).
16. Pollock, D. Pet al.Transgenic milk as a method for the production of recombinant antibodies.J. Immunol. Methods231, 147-157 (1999).
17. W. Mckenzie'sPharmaQuant™. Monoclonal antibodies: on the crest of a wave. Horizons, Pharmaceuticals Issue 6(January 2003).
18. Jerne, N. K. and Melchers, F.25 Years Basel Institute for Immunology Annual Report Introductions.(Roche, Basel, Switzerland, 1996).
19. Soloski, M. J.What on Earth is a Monoclonal Antibody?Johns Hopkins Arthritis Information on monoclonalantibody development (2003).