메뉴 건너뛰기




Volumn 2, Issue 2, 2013, Pages 193-208

Use of a Th1 stimulator adjuvant for vaccination against Neospora caninum infection in the pregnant mouse model

Author keywords

Abortion; Cytokines; Mouse model; Neospora caninum; Pregnancy; Recombinant antigen; Vaccination; Vertical transmission

Indexed keywords

FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; NCMIC3 1 R PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 84899083446     PISSN: None     EISSN: 20760817     Source Type: Journal    
DOI: 10.3390/pathogens2020193     Document Type: Article
Times cited : (9)

References (51)
  • 1
    • 79960306192 scopus 로고    scopus 로고
    • Neosporosis in animals-the last five years
    • Dubey, J.P.; Schares, G. Neosporosis in animals--the last five years. Vet. Parasitol. 2011, 180, 90-108.
    • (2011) Vet. Parasitol , vol.180 , pp. 90-108
    • Dubey, J.P.1    Schares, G.2
  • 2
    • 34248210832 scopus 로고    scopus 로고
    • Epidemiology and control of neosporosis and Neospora caninum
    • Dubey, J.P.; Schares, G.; Ortega-Mora, L.M. Epidemiology and control of neosporosis and Neospora caninum. Clin. Microbiol. Rev. 2007, 20, 323-367.
    • (2007) Clin. Microbiol. Rev , vol.20 , pp. 323-367
    • Dubey, J.P.1    Schares, G.2    Ortega-Mora, L.M.3
  • 3
    • 0034600751 scopus 로고    scopus 로고
    • A European perspective on Neospora caninum
    • Hemphill, A.; Gottstein, B. A European perspective on Neospora caninum. Int. J. Parasitol. 2000, 30, 877-924.
    • (2000) Int. J. Parasitol , vol.30 , pp. 877-924
    • Hemphill, A.1    Gottstein, B.2
  • 4
    • 33750053595 scopus 로고    scopus 로고
    • If control of Neospora caninum infection is technically feasible does it make economic sense?
    • Reichel, M.P.; Ellis, J.T. If control of Neospora caninum infection is technically feasible does it make economic sense? Vet. Parasitol. 2006, 142, 23-34.
    • (2006) Vet. Parasitol , vol.142 , pp. 23-34
    • Reichel, M.P.1    Ellis, J.T.2
  • 5
    • 50349101879 scopus 로고    scopus 로고
    • Re-evaluating the economics of neosporosis control
    • Reichel, M.P.; Ellis, J.T. Re-evaluating the economics of neosporosis control. Vet. Parasitol. 2008, 156, 361-362.
    • (2008) Vet. Parasitol , vol.156 , pp. 361-362
    • Reichel, M.P.1    Ellis, J.T.2
  • 6
    • 0032753956 scopus 로고    scopus 로고
    • Estimation of vertical and horizontal transmission parameters of Neospora caninum infections in dairy cattle
    • Davison, H.C.; Otter, A.; Trees, A.J. Estimation of vertical and horizontal transmission parameters of Neospora caninum infections in dairy cattle. Int. J. Parasitol. 1999, 29, 1683-1689.
    • (1999) Int. J. Parasitol , vol.29 , pp. 1683-1689
    • Davison, H.C.1    Otter, A.2    Trees, A.J.3
  • 7
    • 70449481755 scopus 로고    scopus 로고
    • Endogenous and exogenous transplacental transmission of Neospora caninum - how the route of transmission impacts on epidemiology and control of disease
    • Williams, D.J.; Hartley, C.S.; Bjorkman, C.; Trees, A.J. Endogenous and exogenous transplacental transmission of Neospora caninum - how the route of transmission impacts on epidemiology and control of disease. Parasitology 2009, 136, 1895-1900.
    • (2009) Parasitology , vol.136 , pp. 1895-1900
    • Williams, D.J.1    Hartley, C.S.2    Bjorkman, C.3    Trees, A.J.4
  • 8
    • 34447098446 scopus 로고    scopus 로고
    • Comparative host-parasite relationships in ovine toxoplasmosis and bovine neosporosis and strategies for vaccination
    • Innes, E.A.; Bartley, P.M.; Maley, S.W.; Wright, S.E.; Buxton, D. Comparative host-parasite relationships in ovine toxoplasmosis and bovine neosporosis and strategies for vaccination. Vaccine 2007, 25, 5495-5503.
    • (2007) Vaccine , vol.25 , pp. 5495-5503
    • Innes, E.A.1    Bartley, P.M.2    Maley, S.W.3    Wright, S.E.4    Buxton, D.5
  • 9
    • 33846811391 scopus 로고    scopus 로고
    • Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora
    • Innes, E.A.; Vermeulen, A.N. Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora. Parasitology 2006, 133 (Suppl), S145-S168.
    • (2006) Parasitology , vol.133 , Issue.SUPPL.
    • Innes, E.A.1    Vermeulen, A.N.2
  • 10
    • 67650499884 scopus 로고    scopus 로고
    • Neospora caninum--how close are we to development of an efficacious vaccine that prevents abortion in cattle
    • Reichel, M.P.; Ellis, J.T. Neospora caninum--how close are we to development of an efficacious vaccine that prevents abortion in cattle? Int. J. Parasitol. 2009, 39, 1173-1187.
    • (2009) Int. J. Parasitol , vol.39 , pp. 1173-1187
    • Reichel, M.P.1    Ellis, J.T.2
  • 11
    • 33645093214 scopus 로고    scopus 로고
    • Protecting babies: Vaccine strategies to prevent foetopathy in Neospora caninum-infected cattle
    • Williams, D.J.; Trees, A.J. Protecting babies: Vaccine strategies to prevent foetopathy in Neospora caninum-infected cattle. Parasite Immunol. 2006, 28, 61-67.
    • (2006) Parasite Immunol , vol.28 , pp. 61-67
    • Williams, D.J.1    Trees, A.J.2
  • 12
    • 5444251694 scopus 로고    scopus 로고
    • Effect of a killed whole Neospora caninum tachyzoite vaccine on the crude abortion rate of Costa Rican dairy cows under field conditions
    • Romero, J.J.; Pérez, E.; Frankena, K. Effect of a killed whole Neospora caninum tachyzoite vaccine on the crude abortion rate of Costa Rican dairy cows under field conditions. Vet. Parasitol. 2004, 123, 149-159.
    • (2004) Vet. Parasitol , vol.123 , pp. 149-159
    • Romero, J.J.1    Pérez, E.2    Frankena, K.3
  • 13
    • 84655161479 scopus 로고    scopus 로고
    • Efficacy of a Neospora caninum killed tachyzoite vaccine in preventing abortion and vertical transmission in dairy cattle
    • Weston, J.F.; Heuer, C.; Williamson, N.B. Efficacy of a Neospora caninum killed tachyzoite vaccine in preventing abortion and vertical transmission in dairy cattle. Prev. Vet. Med. 2011, 103, 136-144.
    • (2011) Prev. Vet. Med , vol.103 , pp. 136-144
    • Weston, J.F.1    Heuer, C.2    Williamson, N.B.3
  • 14
    • 33847760357 scopus 로고    scopus 로고
    • Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death
    • Williams, D.J.; Guy, C.S.; Smith, R.F.; Ellis, J.; Bjorkman, C.; Reichel, M.P.; Trees, A.J.; Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death. Infect. Immun. 2007, 75, 1343-1348.
    • (2007) Infect. Immun , vol.75 , pp. 1343-1348
    • Williams, D.J.1    Guy, C.S.2    Smith, R.F.3    Ellis, J.4    Bjorkman, C.5    Reichel, M.P.6    Trees, A.J.7
  • 15
    • 84861657429 scopus 로고    scopus 로고
    • Vaccines against a major cause of abortion in cattle, Neospora caninum infection
    • Monney, T.; Debache, K.; Hemphill, A. Vaccines against a major cause of abortion in cattle, Neospora caninum infection. Animals 2011, 1, 306-325.
    • (2011) Animals , vol.1 , pp. 306-325
    • Monney, T.1    Debache, K.2    Hemphill, A.3
  • 16
    • 33747074886 scopus 로고    scopus 로고
    • Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninum
    • Hemphill, A.; Vonlaufen, N.; Naguleswaran, A. Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninum. Parasitology 2006, 133, 261-278.
    • (2006) Parasitology , vol.133 , pp. 261-278
    • Hemphill, A.1    Vonlaufen, N.2    Naguleswaran, A.3
  • 17
    • 35548978109 scopus 로고    scopus 로고
    • The host-parasite relationship in pregnant cattle infected with Neospora caninum
    • Innes, E.A. The host-parasite relationship in pregnant cattle infected with Neospora caninum. Parasitology 2007, 134, 1903-1910.
    • (2007) Parasitology , vol.134 , pp. 1903-1910
    • Innes, E.A.1
  • 19
    • 33846951501 scopus 로고    scopus 로고
    • Comparative effect of Neospora caninum infection in BALB/c mice at three different gestation periods
    • Lopez-Perez, I.C.; Risco-Castillo, V.; Collantes-Fernandez, E.; Ortega-Mora, L.M. Comparative effect of Neospora caninum infection in BALB/c mice at three different gestation periods. J. Parasitol. 2006, 92, 1286-1291.
    • (2006) J. Parasitol , vol.92 , pp. 1286-1291
    • Lopez-Perez, I.C.1    Risco-Castillo, V.2    Collantes-Fernandez, E.3    Ortega-Mora, L.M.4
  • 20
    • 22244476152 scopus 로고    scopus 로고
    • Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1
    • Alaeddine, F.; Keller, N.; Leepin, A.; Hemphill, A. Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1. J. Parasitol. 2005, 91, 657-665.
    • (2005) J. Parasitol , vol.91 , pp. 657-665
    • Alaeddine, F.1    Keller, N.2    Leepin, A.3    Hemphill, A.4
  • 21
    • 0037325687 scopus 로고    scopus 로고
    • Reduced cerebral infection of Neospora caninum-infected mice after vaccination with recombinant microneme protein NcMIC3 and ribi adjuvant
    • Cannas, A.; Naguleswaran, A.; Muller, N.; Gottstein, B.; Hemphill, A. Reduced cerebral infection of Neospora caninum-infected mice after vaccination with recombinant microneme protein NcMIC3 and ribi adjuvant. J. Parasitol. 2003, 89, 44-50.
    • (2003) J. Parasitol , vol.89 , pp. 44-50
    • Cannas, A.1    Naguleswaran, A.2    Muller, N.3    Gottstein, B.4    Hemphill, A.5
  • 22
    • 51249107767 scopus 로고    scopus 로고
    • Vaccination of mice with recombinant NcROP2 antigen reduces mortality and cerebral infection in mice infected with Neospora caninum tachyzoites
    • Debache, K.; Guionaud, C.; Alaeddine, F.; Mevissen, M.; Hemphill, A. Vaccination of mice with recombinant NcROP2 antigen reduces mortality and cerebral infection in mice infected with Neospora caninum tachyzoites. Int. J. Parasitol. 2008, 38, 1455-1463.
    • (2008) Int. J. Parasitol , vol.38 , pp. 1455-1463
    • Debache, K.1    Guionaud, C.2    Alaeddine, F.3    Mevissen, M.4    Hemphill, A.5
  • 23
    • 68049137627 scopus 로고    scopus 로고
    • Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites
    • Debache, K.; Alaeddine, F.; Guionaud, C.; Monney, T.; Muller, J.; Strohbusch, M.; Leib, S.L.; Grandgirard, D.; Hemphill, A. Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. Int. J. Parasitol. 2009, 39, 1373-1384.
    • (2009) Int. J. Parasitol , vol.39 , pp. 1373-1384
    • Debache, K.1    Alaeddine, F.2    Guionaud, C.3    Monney, T.4    Muller, J.5    Strohbusch, M.6    Leib, S.L.7    Grandgirard, D.8    Hemphill, A.9
  • 24
    • 80052337442 scopus 로고    scopus 로고
    • RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection
    • Monney, T.; Rütti, D.; Schorer, M.; Debache, K.; Grandgirard, D.; Leib, S.L.; Hemphill, A.; RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection. Vaccine 2011, 29, 6967-6975.
    • (2011) Vaccine , vol.29 , pp. 6967-6975
    • Monney, T.1    Rütti, D.2    Schorer, M.3    Debache, K.4    Grandgirard, D.5    Leib, S.L.6    Hemphill, A.7
  • 25
    • 84866995367 scopus 로고    scopus 로고
    • Vaccination with the recombinant chimeric antigen recNcMIC3-1-R induces a non-protective Th2-type immune response in the pregnant mouse model for
    • Monney, T.; Debache, K.; Grandgirard, D.; Leib, S.L.; Hemphill, A. Vaccination with the recombinant chimeric antigen recNcMIC3-1-R induces a non-protective Th2-type immune response in the pregnant mouse model for N. caninum infection. Vaccine 2012, 30, 6588-6594.
    • (2012) N. Caninum Infection. Vaccine , vol.30 , pp. 6588-6594
    • Monney, T.1    Debache, K.2    Grandgirard, D.3    Leib, S.L.4    Hemphill, A.5
  • 26
    • 0024328379 scopus 로고    scopus 로고
    • Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: The role of endogenous interleukin 1 in proliferative responses
    • Grun, J.L.; Maurer, P.H. Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: the role of endogenous interleukin 1 in proliferative responses. Cell. Immunol. 1998, 121, 134-145.
    • (1998) Cell. Immunol , vol.121 , pp. 134-145
    • Grun, J.L.1    Maurer, P.H.2
  • 27
    • 77956136738 scopus 로고    scopus 로고
    • Neospora caninum tachyzoite- and antigen-stimulated cytokine production by bone marrow-derived dendritic cells and spleen cells of naive BALB/c Mice
    • Feng, X.; Zhang, N.; Tuo, W. Neospora caninum tachyzoite- and antigen-stimulated cytokine production by bone marrow-derived dendritic cells and spleen cells of naive BALB/c Mice. J. Parasitol 2010, 96, 717-723.
    • (2010) J. Parasitol , vol.96 , pp. 717-723
    • Feng, X.1    Zhang, N.2    Tuo, W.3
  • 29
    • 0033404134 scopus 로고    scopus 로고
    • Prevention of vertical transfer of Neospora caninum in BALB/c mice by vaccination
    • Liddell, S.; Jenkins, M.C.; Collica, C.M.; Dubey, J.P. Prevention of vertical transfer of Neospora caninum in BALB/c mice by vaccination. J. Parasitol. 1999, 85, 1072-1075.
    • (1999) J. Parasitol , vol.85 , pp. 1072-1075
    • Liddell, S.1    Jenkins, M.C.2    Collica, C.M.3    Dubey, J.P.4
  • 30
    • 0034152813 scopus 로고    scopus 로고
    • The inhibitory effect of interferon gamma and tumor necrosis factor alpha on intracellular multiplication of Neospora caninum in primary bovine brain cells
    • Yamane, I.; Kitani, H.; Kokuho, T.; Shibahara, T.; Haritani, M.; Hamaoka, T.; Shimizu, S.; Koiwai, M.; Shimura, K.; Yokomizo, Y. The inhibitory effect of interferon gamma and tumor necrosis factor alpha on intracellular multiplication of Neospora caninum in primary bovine brain cells. J. Vet. Med. Sci. 2000, 62, 347-351.
    • (2000) J. Vet. Med. Sci , vol.62 , pp. 347-351
    • Yamane, I.1    Kitani, H.2    Kokuho, T.3    Shibahara, T.4    Haritani, M.5    Hamaoka, T.6    Shimizu, S.7    Koiwai, M.8    Shimura, K.9    Yokomizo, Y.10
  • 31
    • 0032745343 scopus 로고    scopus 로고
    • Interferon-gamma and interleukin-12 mediate protection to acute Neospora caninum infection in BALB/c mice
    • Baszler, T.V.; Long, M.T.; McElwain, T.F.; Mathison, B.A. Interferon-gamma and interleukin-12 mediate protection to acute Neospora caninum infection in BALB/c mice. Int. J. Parasitol. 1999, 29, 1635-1646.
    • (1999) Int. J. Parasitol , vol.29 , pp. 1635-1646
    • Baszler, T.V.1    Long, M.T.2    McElwain, T.F.3    Mathison, B.A.4
  • 32
    • 66949180082 scopus 로고    scopus 로고
    • The development of immune responses in BALB/c mice following inoculation with attenuated or virulent Neospora caninum tachyzoites
    • Bartley, P.M.; Wright, S.E.; Maley, S.W.; Buxton, D.; Nath, M.; Innes, E.A. The development of immune responses in BALB/c mice following inoculation with attenuated or virulent Neospora caninum tachyzoites. Parasite Immunol. 2009, 31, 392-401.
    • (2009) Parasite Immunol , vol.31 , pp. 392-401
    • Bartley, P.M.1    Wright, S.E.2    Maley, S.W.3    Buxton, D.4    Nath, M.5    Innes, E.A.6
  • 34
    • 1542614135 scopus 로고    scopus 로고
    • A role for balance of interferon-gamma and interleukin-4 production in protective immunity against Neospora caninum infection
    • Nishikawa, Y.; Inoue, N.; Makala, L.; Nagasawa, H. A role for balance of interferon-gamma and interleukin-4 production in protective immunity against Neospora caninum infection. Vet. Parasitol. 2003, 116, 175-184.
    • (2003) Vet. Parasitol , vol.116 , pp. 175-184
    • Nishikawa, Y.1    Inoue, N.2    Makala, L.3    Nagasawa, H.4
  • 35
    • 16244423286 scopus 로고    scopus 로고
    • Relationship between type 1/type 2 immune responses and occurrence of vertical transmission in BALB/c mice infected with Neospora caninum
    • Kano, R.; Masukata, Y.; Omata, Y.; Kobayashi, Y.; Maeda, R.; Saito, A. Relationship between type 1/type 2 immune responses and occurrence of vertical transmission in BALB/c mice infected with Neospora caninum. Vet. Parasitol. 2005, 129, 159-164.
    • (2005) Vet. Parasitol , vol.129 , pp. 159-164
    • Kano, R.1    Masukata, Y.2    Omata, Y.3    Kobayashi, Y.4    Maeda, R.5    Saito, A.6
  • 36
    • 1942477562 scopus 로고    scopus 로고
    • The cell-mediated immune response to Neospora caninum during pregnancy in the mouse is associated with a bias towards production of interleukin-4
    • Quinn, H.E.; Miller, C.M.D.; Ellis, J.T. The cell-mediated immune response to Neospora caninum during pregnancy in the mouse is associated with a bias towards production of interleukin-4. Int. J. Parasitol. 2004, 34, 723-732.
    • (2004) Int. J. Parasitol , vol.34 , pp. 723-732
    • Quinn, H.E.1    Miller, C.M.D.2    Ellis, J.T.3
  • 37
    • 0034462220 scopus 로고    scopus 로고
    • Immunization of BALB/c mice with killed Neospora caninum tachyzoite antigen induces a type 2 immune response and exacerbates encephalitis and neurological disease
    • Baszler, T.V.; McElwain, T.F.; Mathison, B.A. Immunization of BALB/c mice with killed Neospora caninum tachyzoite antigen induces a type 2 immune response and exacerbates encephalitis and neurological disease. Clin. Diagn. Lab. Immunol. 2000, 7, 893-898.
    • (2000) Clin. Diagn. Lab. Immunol , vol.7 , pp. 893-898
    • Baszler, T.V.1    McElwain, T.F.2    Mathison, B.A.3
  • 38
    • 0031957265 scopus 로고    scopus 로고
    • Comparison of intracerebral parasite load, lesion development, and systemic cytokines in mouse strains infected with Neospora caninum
    • Long, M.T.; Baszler, T.V.; Mathison, B.A. Comparison of intracerebral parasite load, lesion development, and systemic cytokines in mouse strains infected with Neospora caninum. J. Parasitol. 1998, 84, 316-320.
    • (1998) J. Parasitol , vol.84 , pp. 316-320
    • Long, M.T.1    Baszler, T.V.2    Mathison, B.A.3
  • 40
    • 46249103012 scopus 로고    scopus 로고
    • Upregulation of cytokines is detected in the placentas of cattle infected with Neospora caninum and is more marked early in gestation when fetal death is observed
    • Rosbottom, A.; Gibney, E.H.; Guy, C.S.; Kipar, A.; Smith, R.F.; Kaiser, P.; Trees, A.J.; Williams, D.J. Upregulation of cytokines is detected in the placentas of cattle infected with Neospora caninum and is more marked early in gestation when fetal death is observed. Infect. Immun. 2008, 76, 2352-2361.
    • (2008) Infect. Immun , vol.76 , pp. 2352-2361
    • Rosbottom, A.1    Gibney, E.H.2    Guy, C.S.3    Kipar, A.4    Smith, R.F.5    Kaiser, P.6    Trees, A.J.7    Williams, D.J.8
  • 43
    • 63449138101 scopus 로고    scopus 로고
    • CpG-ODN combined with Neospora caninum lysate, but not with excretedsecreted antigen, enhances protection against infection in mice
    • Ribeiro, D.P.; Freitas, M.M.; Cardoso, M.R.; Pajuaba, A.C.; Silva, N.M.; Mineo, T.W.; Silva, J.S.; Mineo, J.R.; Silva, D.A. CpG-ODN combined with Neospora caninum lysate, but not with excretedsecreted antigen, enhances protection against infection in mice. Vaccine 2009, 27, 2570-2579.
    • (2009) Vaccine , vol.27 , pp. 2570-2579
    • Ribeiro, D.P.1    Freitas, M.M.2    Cardoso, M.R.3    Pajuaba, A.C.4    Silva, N.M.5    Mineo, T.W.6    Silva, J.S.7    Mineo, J.R.8    Silva, D.A.9
  • 45
    • 77949653962 scopus 로고    scopus 로고
    • Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites
    • Debache, K.; Guionaud, C.; Alaeddine, F.; Hemphill, A. Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites. Parasitology 2010, 137, 229-240.
    • (2010) Parasitology , vol.137 , pp. 229-240
    • Debache, K.1    Guionaud, C.2    Alaeddine, F.3    Hemphill, A.4
  • 46
    • 84861683793 scopus 로고    scopus 로고
    • Intra-cisternal vaccination induces high-level protection against Neospora caninum infection in mice
    • Debache, K.; Hemphill, A. Intra-cisternal vaccination induces high-level protection against Neospora caninum infection in mice. Vaccine 2012, 30, 4209-4215.
    • (2012) Vaccine , vol.30 , pp. 4209-4215
    • Debache, K.1    Hemphill, A.2
  • 48
    • 0030023672 scopus 로고    scopus 로고
    • Adhesion and invasion of bovine endothelial cells by Neospora caninum
    • Hemphill, A.; Gottstein, B.; Kaufmann, H. Adhesion and invasion of bovine endothelial cells by Neospora caninum. Parasitology 1996, 112, 183-197.
    • (1996) Parasitology , vol.112 , pp. 183-197
    • Hemphill, A.1    Gottstein, B.2    Kaufmann, H.3
  • 49
    • 0003421717 scopus 로고
    • Effect of exteroceptive factors on the oestrous cycle of mice
    • Whitten, M.K. Effect of exteroceptive factors on the oestrous cycle of mice. Nature 1957, 180, 1436.
    • (1957) Nature , vol.180 , pp. 1436
    • Whitten, M.K.1
  • 50
    • 0036136354 scopus 로고    scopus 로고
    • Application of real-time fluorescent PCR for quantitative assessment of Neospora caninum infections in organotypic slice cultures of rat central nervous system tissue
    • Müller, N.; Vonlaufen, N.; Gianinazzi, C.; Leib, S.L.; Hemphill, A. Application of real-time fluorescent PCR for quantitative assessment of Neospora caninum infections in organotypic slice cultures of rat central nervous system tissue. J. Clin. Microbiol. 2002, 40, 252-255.
    • (2002) J. Clin. Microbiol , vol.40 , pp. 252-255
    • Müller, N.1    Vonlaufen, N.2    Gianinazzi, C.3    Leib, S.L.4    Hemphill, A.5
  • 51
    • 84855233470 scopus 로고    scopus 로고
    • A new cloning system based on the OprI lipoprotein for the production of recombinant bacterial cell wall-derived immunogenic formulations
    • Basto, A.; Piedade, J.; Ramalho, R.; Alves, S.; Soares, H.; Cornelis, P.; Martins, C.; Leitao, A. A new cloning system based on the OprI lipoprotein for the production of recombinant bacterial cell wall-derived immunogenic formulations. J. Biotechnol. 2012, 157, 50-63.
    • (2012) J. Biotechnol , vol.157 , pp. 50-63
    • Basto, A.1    Piedade, J.2    Ramalho, R.3    Alves, S.4    Soares, H.5    Cornelis, P.6    Martins, C.7    Leitao, A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.