Influence of adjuvant and antigen dose on protection induced by an inactivated whole vaccine against Neospora caninum infection in mice

Veterinary Parasitology

Volumn 175, Issue 3-4, 2011, Pages 220-229

  Rojo Montejo, Silvia ^a   Collantes Fernández, Esther ^a   Regidor Cerrillo, Javier ^a   Rodríguez Bertos, Antonio ^a   Prenafeta, Antoni ^b   Gomez Bautista, Mercedes ^a   Ortega Mora, Luis M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b LABORATORIOS HIPRA S A   (Spain)

Author keywords

Adjuvant; Inactivated vaccine; Mice; Neospora caninum

Indexed keywords

ALUMINUM HYDROXIDE; CPG OLIGODEOXYNUCLEOTIDE; GINSENG EXTRACT; INACTIVATED VACCINE; WATER OIL CREAM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG MEGADOSE; DRUG MIXTURE; FEMALE; INFECTION PREVENTION; LOW DRUG DOSE; MOUSE; NEOSPORA CANINUM; NEOSPOROSIS; NONHUMAN; OUTCOME ASSESSMENT; PARASITE LOAD; TACHYZOITE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; BRAIN; COCCIDIOSIS; DNA, PROTOZOAN; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; IMMUNOGLOBULIN G; INJECTIONS, SUBCUTANEOUS; LUNG; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; NEOSPORA; PARASITEMIA; PROTOZOAN VACCINES; TIME FACTORS; VACCINATION; VACCINES, INACTIVATED;

MUS; NEOSPORA CANINUM; PANAX GINSENG;

EID: 78751614987     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2010.10.028     Document Type: Article

References (53)

1. Aguilar J.C., Rodriguez E.G. Vaccine adjuvants revisited. Vaccine 2007, 25(19):3752-3762.
2. Alaeddine F., Keller N., Leepin A., Hemphill A. Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1. J. Parasitol. 2005, 91(3):657-665.
3. Andrianarivo A.G., Rowe J.D., Barr B.C., Anderson M.L., Packham A.E., Sverlow K.W., Choromanski L., Loui C., Grace A., Conrad P.A. A POLYGEN-adjuvanted killed Neospora caninum tachyzoite preparation failed to prevent foetal infection in pregnant cattle following i.v./i.m. experimental tachyzoite challenge. Int. J. Parasitol. 2000, 30(9):985-990.
4. Atkinson R., Harper P.A., Ryce C., Morrison D.A., Ellis J.T. Comparison of the biological characteristics of two isolates of Neospora caninum. Parasitology 1999, 118(Pt 4):363-370.
5. Aucouturier J., Dupuis L., Ganne V. Adjuvants designed for veterinary and human vaccines. Vaccine 2001, 19(17-19):2666-2672.
6. Baszler T.V., McElwain T.F., Mathison B.A. Immunization of BALB/c mice with killed Neospora caninum tachyzoite antigen induces a type 2 immune response and exacerbates encephalitis and neurological disease. Clin. Diagn. Lab. Immunol. 2000, 7(6):893-898.
7. Blackburn N.K., Besselaar T.G. A study of the effect of chemical inactivants on the epitopes of Rift Valley fever virus glycoproteins using monoclonal antibodies. J. Virol. Methods 1991, 33(3):367-374.
8. Brewer J.M., Alexander J. Cytokines and the mechanisms of action of vaccine adjuvants. Cytokines Cell. Mol. Ther. 1997, 3(4):233-246.
9. Buxton D., Maley S.W., Wright S., Thomson K.M., Rae A.G., Innes E.A. The pathogenesis of experimental neosporosis in pregnant sheep. J. Comp. Pathol. 1998, 118(4):267-279.
10. Cannas A., Naguleswaran A., Muller N., Eperon S., Gottstein B., Hemphill A. Vaccination of mice against experimental Neospora caninum infection using NcSAG1- and NcSRS2-based recombinant antigens and DNA vaccines. Parasitology 2003, 126(Pt 4):303-312.
11. Coler R.N., Carter D., Friede M., Reed S.G. Adjuvants for malaria vaccines. Parasite Immunol. 2009, 31(9):520-528.
12. Collantes-Fernandez E., Alvarez-Garcia G., Perez-Perez V., Pereira-Bueno J., Ortega-Mora L.M. Characterization of pathology and parasite load in outbred and inbred mouse models of chronic Neospora caninum infection. J. Parasitol. 2004, 90(3):579-583.
13. Collantes-Fernandez E., Lopez-Perez I., Alvarez-Garcia G., Ortega-Mora L.M. Temporal distribution and parasite load kinetics in blood and tissues during Neospora caninum infection in mice. Infect. Immun. 2006, 74(4):2491-2494.
14. Collantes-Fernandez E., Zaballos A., Alvarez-Garcia G., Ortega-Mora L.M. Quantitative detection of Neospora caninum in bovine aborted fetuses and experimentally infected mice by real-time PCR. J. Clin. Microbiol. 2002, 40(4):1194-1198.
15. Davis H.L., Weeratna R., Waldschmidt T.J., Tygrett L., Schorr J., Krieg A.M. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 1998, 160(2):870-876.
16. Debache K., Guionaud C., Alaeddine F., Mevissen M., Hemphill A. Vaccination of mice with recombinant NcROP2 antigen reduces mortality and cerebral infection in mice infected with Neospora caninum tachyzoites. Int. J. Parasitol. 2008, 38(12):1455-1463.
17. Dubey J.P., Hattel A.L., Lindsay D.S., Topper M.J. Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission. J. Am. Vet. Med. Assoc. 1988, 193(10):1259-1263.
18. Dubey J.P., Lindsay D.S. A review of Neospora caninum and neosporosis. Vet. Parasitol. 1996, 67(1-2):1-59.
19. Dubey J.P., Schares G., Ortega-Mora L.M. Epidemiology and control of neosporosis and Neospora caninum. Clin. Microbiol. Rev. 2007, 20(2):323-367.
20. Eperon S., Bronnimann K., Hemphill A., Gottstein B. Susceptibility of B-cell deficient C57BL/6 (microMT) mice to Neospora caninum infection. Parasite Immunol. 1999, 21(5):225-236.
21. Hosken N.A., Shibuya K., Heath A.W., Murphy K.M., O'Garra A. The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J. Exp. Med. 1995, 182(5):1579-1584.
22. Innes E.A., Andrianarivo A.G., Bjorkman C., Williams D.J., Conrad P.A. Immune responses to Neospora caninum and prospects for vaccination. Trends Parasitol. 2002, 18(11):497-504.
23. Innes E.A., Vermeulen A.N. Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora. Parasitology 2006, 133(Suppl):S145-S168.
24. Klevar S., Kulberg S., Boysen P., Storset A.K., Moldal T., Bjorkman C., Olsen I. Natural killer cells act as early responders in an experimental infection with Neospora caninum in calves. Int. J. Parasitol. 2007, 37(3-4):329-339.
25. Lambert H., Hitziger N., Dellacasa I., Svensson M., Barragan A. Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination. Cell. Microbiol. 2006, 8(10):1611-1623.
26. Liddell S., Jenkins M.C., Collica C.M., Dubey J.P. Prevention of vertical transfer of Neospora caninum in BALB/c mice by vaccination. J. Parasitol. 1999, 85(6):1072-1075.
27. Lindblad E.B. Aluminium adjuvants-in retrospect and prospect. Vaccine 2004, 22(27-28):3658-3668.
28. Lindsay D.S., Lenz S.D., Blagburn B.L., Brake D.A. Characterization of temperature-sensitive strains of Neospora caninum in mice. J. Parasitol. 1999, 85(1):64-67.
29. Lindsay D.S., Lenz S.D., Cole R.A., Dubey J.P., Blagburn B.L. Mouse model for central nervous system Neospora caninum infections. J. Parasitol. 1995, 81(2):313-315.
30. Lunden A., Wright S., Allen J.E., Buxton D. Immunisation of mice against neosporosis. Int. J. Parasitol. 2002, 32(7):867-876.
31. Martin V., Supanitsky A., Echeverria P.C., Litwin S., Tanos T., De Roodt A.R., Guarnera E.A., Angel S.O. Recombinant GRA4 or ROP2 protein combined with alum or the gra4 gene provides partial protection in chronic murine models of toxoplasmosis. Clin. Diagn. Lab. Immunol. 2004, 11(4):704-710.
32. Miller C., Quinn H., Ryce C., Reichel M.P., Ellis J.T. Reduction in transplacental transmission of Neospora caninum in outbred mice by vaccination. Int. J. Parasitol. 2005, 35(7):821-828.
33. Morrison D.A. How to improve statistical analysis in parasitology research publications. Int. J. Parasitol. 2002, 32(8):1065-1070.
34. Mutwiri G.K., Nichani A.K., Babiuk S., Babiuk L.A. Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides. J. Control. Release 2004, 97(1):1-17.
35. Near K.A., Stowers A.W., Jankovic D., Kaslow D.C. Improved immunogenicity and efficacy of the recombinant 19-kilodalton merozoite surface protein 1 by the addition of oligodeoxynucleotide and aluminum hydroxide gel in a murine malaria vaccine model. Infect. Immun. 2002, 70(2):692-701.
36. Pereira Garcia-Melo D., Regidor-Cerrillo J., Collantes-Fernandez E., Aguado-Martinez A., Del Pozo I., Minguijon E., Gomez-Bautista M., Aduriz G., Ortega-Mora L.M. Pathogenic characterization in mice of Neospora caninum isolates obtained from asymptomatic calves. Parasitology 2010, 137(7):1057-1068.
37. Perez-Zaballos F.J., Ortega-Mora L.M., Alvarez-Garcia G., Collantes-Fernandez E., Navarro-Lozano V., Garcia-Villada L., Costas E. Adaptation of Neospora caninum isolates to cell-culture changes: an argument in favor of its clonal population structure. J. Parasitol. 2005, 91(3):507-510.
38. Petersen E., Nielsen H.V., Christiansen L., Spenter J. Immunization with E. coli produced recombinant T. gondii SAG1 with alum as adjuvant protect mice against lethal infection with Toxoplasma gondii. Vaccine 1998, 16(13):1283-1289.
39. Pinitkiatisakul S., Mattsson J.G., Lunden A. Quantitative analysis of parasite DNA in the blood of immunized and naive mice after infection with Neospora caninum. Parasitology 2008, 135(2):175-182.
40. Ramamoorthy S., Lindsay D.S., Schurig G.G., Boyle S.M., Duncan R.B., Vemulapalli R., Sriranganathan N. Vaccination with gamma-irradiated Neospora caninum tachyzoites protects mice against acute challenge with N. caninum. J. Eukaryot. Microbiol. 2006, 53(2):151-156.
41. Ribeiro D.P., Freitas M.M., Cardoso M.R., Pajuaba A.C., Silva N.M., Mineo T.W., Silva J.S., Mineo J.R., Silva D.A. CpG-ODN combined with Neospora caninum lysate, but not with excreted-secreted antigen, enhances protection against infection in mice. Vaccine 2009, 27(19):2570-2579.
42. Rivera E., Ekholm Pettersson F., Inganas M., Paulie S., Gronvik K.O. The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response. Vaccine 2005, 23(46-47):5411-5419.
43. Rivera E., Hu S., Concha C. Ginseng and aluminium hydroxide act synergistically as vaccine adjuvants. Vaccine 2003, 21(11-12):1149-1157.
44. Rojo-Montejo S., Collantes-Fernandez E., Blanco-Murcia J., Rodriguez-Bertos A., Risco-Castillo V., Ortega-Mora L.M. Experimental infection with a low virulence isolate of Neospora caninum at 70 days gestation in cattle did not result in foetopathy. Vet. Res. 2009, 40(5):49.
45. Rojo-Montejo S., Collantes-Fernandez E., Regidor-Cerrillo J., Alvarez-Garcia G., Marugan-Hernandez V., Pedraza-Diaz S., Blanco-Murcia J., Prenafeta A., Ortega-Mora L.M. Isolation and characterization of a bovine isolate of Neospora caninum with low virulence. Vet. Parasitol. 2009, 159(1):7-16.
46. Song X., Hu S. Adjuvant activities of saponins from traditional Chinese medicinal herbs. Vaccine 2009, 27(36):4883-4890.
47. Staska L.M., McGuire T.C., Davies C.J., Lewin H.A., Baszler T.V. Neospora caninum-infected cattle develop parasite-specific CD4+ cytotoxic T lymphocytes. Infect. Immun. 2003, 71(6):3272-3279.
48. Su Z., Tam M.F., Jankovic D., Stevenson M.M. Vaccination with novel immunostimulatory adjuvants against blood-stage malaria in mice. Infect. Immun. 2003, 71(9):5178-5187.
49. Sun J., Hu S., Song X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine 2007, 25(6):1114-1120.
50. Sun J., Song X., Hu S. Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice. Clin. Vaccine Immunol. 2008, 15(2):303-307.
51. Tonui W.K., Mejia J.S., Hochberg L., Mbow M.L., Ryan J.R., Chan A.S., Martin S.K., Titus R.G. Immunization with Leishmania major exogenous antigens protects susceptible BALB/c mice against challenge infection with L. major. Infect. Immun. 2004, 72(10):5654-5661.
52. Tritto E., Mosca F., De Gregorio E. Mechanism of action of licensed vaccine adjuvants. Vaccine 2009, 27(25-26):3331-3334.
53. Williams D.J., Guy C.S., Smith R.F., Ellis J., Bjorkman C., Reichel M.P., Trees A.J. Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death. Infect. Immun. 2007, 75(3):1343-1348.