Intra-cisternal vaccination induces high-level protection against Neospora caninum infection in mice

Vaccine

Volumn 30, Issue 28, 2012, Pages 4209-4215

  Debache, Karim ^a   Hemphill, Andrew ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Antibodies; Cerebral infection; Cytokines; Intracisternal vaccination; Intraperitoneal vaccination; Neospora caninum

Indexed keywords

FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MESSENGER RNA; NEOSPOROSIS VACCINE; PROTOZOAL VACCINE; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL INFECTION; FEMALE; HUMORAL IMMUNITY; INTERFERON PRODUCTION; MOUSE; NEOSPORA CANINUM; NEOSPOROSIS; NONHUMAN; PARASITE LOAD; PRIORITY JOURNAL; RNA ANALYSIS; TACHYZOITE; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, PROTOZOAN; BRAIN; COCCIDIOSIS; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION PROFILING; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; NEOSPORA; PARASITE LOAD; PROTOZOAN VACCINES; SPLEEN; SURVIVAL ANALYSIS; VACCINATION;

EID: 84861683793     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.04.050     Document Type: Article

References (48)

1. Dubey J.P., Schares G., Ortega-Mora L.M. Epidemiology and control of neosporosis and Neospora caninum. Clinical Microbiology Reviews 2007, 20(2):323-367.
2. Innes E.A., Wright S.E., Maley S., Rae A., Schock A., Kirvar E., et al. Protection against vertical transmission in bovine neosporosis. International Journal for Parasitology 2001, 31(13):1523-1534.
3. Omata Y., Nidaira M., Kano R., Kobayashi Y., Koyama T., Furuoka H., et al. Vertical transmission of Neospora caninum in BALB/c mice in both acute and chronic infection. Veterinary Parasitology 2004, 121(3-4):323-328.
4. Anderson M.L., Reynolds J.P., Rowe J.D., Sverlow K.W., Packham A.E., Barr B.C., et al. Evidence of vertical transmission of Neospora sp infection in dairy cattle. Journal of the American Veterinary Medical Association 1997, 210(8):1169-1172.
5. Dubey J.P., Schares G Neosporosis in animals - the last five years. Veterinary Parasitology 2011, 180(1-2):90-108.
6. Monney T., Debache K., Hemphill A. Vaccines against a major cause of abortion in cattle: Neospora caninum infection. Animals 2011, 1(3):306-325.
7. Ellis J., Miller C., Quinn H., Ryce C., Reichel M.P. Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model). Vaccine 2008, 26(47):5989-5996.
8. Haldorson G.J., Mathison B.A., Wenberg K., Conrad P.A., Dubey J.P., Trees A.J., et al. Immunization with native surface protein NcSRS2 induces a Th2 immune response and reduces congenital Neospora caninum transmission in mice. International Journal for Parasitology 2005, 35(13):1407-1415.
9. Marugan-Hernandez V., Ortega-Mora L.M., Aguado-Martinez A., Jimenez-Ruiz E., Alvarez-Garcia G Transgenic Neospora caninum strains constitutively expressing the bradyzoite NcSAG4 protein proved to be safe and conferred significant levels of protection against vertical transmission when used as live vaccines in mice. Vaccine 2011, 29(44):7867-7874.
10. Debache K., Guionaud C., Alaeddine F., Mevissen M., Hemphill A. Vaccination of mice with recombinant NcROP2 antigen reduces mortality and cerebral infection in mice infected with Neospora caninum tachyzoites. International Journal for Parasitology 2008, 38(12):1455-1463.
11. Debache K., Alaeddine F., Guionaud C., Monney T., Muller J., Strohbusch M., et al. Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. International Journal for Parasitology 2009, 39(12):1373-1384.
12. Khan I.A., Schwartzman J.D., Fonseka S., Kasper L.H. Neospora caninum: role for immune cytokines in host immunity. Experimental Parasitology 1997, 85(1):24-34.
13. Yamane I., Kitani H., Kokuho T., Shibahara T., Haritani M., Hamaoka T., et al. The inhibitory effect of interferon gamma and tumor necrosis factor alpha on intracellular multiplication of Neospora caninum in primary bovine brain cells. Journal of Veterinary Medical Science 2000, 62(3):347-351.
14. Williams D.J., Guy C.S., Smith R.F., Ellis J., Bjorkman C., Reichel M.P., et al. Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death. Infection and Immunity 2007, 75(3):1343-1348.
15. Innes E.A., Vermeulen AN Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora. Parasitology 2006, 133(Suppl):S145-S168.
16. Nishikawa Y., Mikami T., Nagasawa H. Vaccine development against Neospora caninum infection. Journal of Veterinary Medical Science 2002, 64(1):1-5.
17. Bigalke R.D., Schoeman J.H., McCully R.M. Immunization against bovine besnoitiosis with a live vaccine prepared from a blue wildebeest strain of Besnoitia besnoiti grown in cell cultures. 1. Studies on rabbits. Onderstepoort Journal of Veterinary Research 1974, 41(1):1-5.
18. Buxton D., Thomson K.M., Maley S., Wright S., Bos H.J. Experimental challenge of sheep 18 months after vaccination with a live (S48) Toxoplasma gondii vaccine. Veterinary Record 1993, 133(13):310-312.
19. Miller C., Quinn H., Ryce C., Reichel M.P., Ellis J.T. Reduction in transplacental transmission of Neospora caninum in outbred mice by vaccination. International Journal for Parasitology 2005, 35(7):821-828.
20. Williams D.J., Trees A.J. Protecting babies: vaccine strategies to prevent foetopathy in Neospora caninum-infected cattle. Parasite Immunology 2006, 28(3):61-67.
21. Weston J.F., Heuer C., Williamson N.B. Efficacy of a Neospora caninum killed tachyzoite vaccine in preventing abortion and vertical transmission in dairy cattle. Preventive Veterinary Medicine 2011, 103(2-3):136-144.
22. Liddell S., Jenkins M.C., Collica C.M., Dubey J.P. Prevention of vertical transfer of Neospora caninum in BALB/c mice by vaccination. Journal of Parasitology 1999, 85(6):1072-1075.
23. Monney T., Rutti D., Schorer M., Debache K., Grandgirard D., Leib S.L., et al. RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection. Vaccine 2011, 29(40):6967-6975.
24. Neumann H. Microglia: a cellular vehicle for CNS gene therapy. Journal of Clinical Investigation 2006, 116(11):2857-2860.
25. Shin J.H., Sakoda Y., Kim J.H., Ochiai K., Umemura T. Comparison of antibody titers in rabbits following immunization with inactivated influenza virus via subarachnoidal or subcutaneous route. Journal of Veterinary Medical Science 2007, 69(11):1167-1169.
26. Sunden Y., Yano S., Ishida S., Ochiai K., Umemura T Intracerebral vaccination suppresses the spread of rabies virus in the mouse brain. Microbes and Infection 2010, 12(14-15):1163-1169.
27. Harling-Berg C., Knopf P.M., Merriam J., Cserr H.F. Role of cervical lymph nodes in the systemic humoral immune response to human serum albumin microinfused into rat cerebrospinal fluid. Journal of Neuroimmunology 1989, 25(2-3):185-193.
28. Dubey J.P., Hattel A.L., Lindsay D.S., Topper M.J. Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission. Journal of the American Veterinary Medical Association 1988, 1988(193):1259-1263.
29. Alaeddine F., Keller N., Leepin A., Hemphill A. Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1. Journal of Parasitology 2005, 91(3):657-665.
30. Yamazaki H., Arai M., Matsumura S., Inoue K., Fushiki T. Intracranial administration of transforming growth factor-beta3 increases fat oxidation in rats. American Journal of Physiology Endocrinology and Metabolism 2002, 283(3):E536-E544.
31. Patwardhan R.V., Calvert J.W., Besio W., Kusaka G., Kusaka I., Zhang J., et al. Technical note: preliminary results in development of a novel intracisternal penicillin seizure model in the rat. Frontiers in Bioscience 2005, 10:3009-3012.
32. Matsumura S., Shibakusa T., Fujikawa T., Yamada H., Matsumura K., Inoue K., et al. Intracisternal administration of transforming growth factor-beta evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2008, 294(1):R266-R275.
33. Debache K., Guionaud C., Alaeddine F., Hemphill A Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites. Parasitology 2010, 137(2):229-240.
34. Debache K., Guionaud C., Kropf C., Boykin D., Stephens C.E., Hemphill A Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide. Experimental Parasitology 2011, 129(2):95-100.
35. Muller N., Vonlaufen N., Gianinazzi C., Leib S.L., Hemphill A. Application of real-time fluorescent PCR for quantitative assessment of Neospora caninum infections in organotypic slice cultures of rat central nervous system tissue. Journal of Clinical Microbiology 2002, 40(1):252-255.
36. Srinivasan S., Mueller J., Suana A., Hemphill A. Vaccination with microneme protein NcMIC4 increases mortality in mice inoculated with Neospora caninum. Journal of Parasitology 2007, 93(5):1046-1055.
37. Overbergh L., Valckx D., Waer M., Mathieu C. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 1999, 11(4):305-312.
38. Innes E.A., Andrianarivo A.G., Bjorkman C., Williams D.J., Conrad P.A. Immune responses to Neospora caninum and prospects for vaccination. Trends in Parasitology 2002, 18(11):497-504.
39. Harling-Berg C.J., Knopf P.M., Cserr H.F. Myelin basic protein infused into cerebrospinal fluid suppresses experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 1991, 35(1-3):45-51.
40. Knopf P.M., Harling-Berg C.J., Cserr H.F., Basu D., Sirulnick E.J., Nolan S.C., et al. Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells. Journal of Immunology 1998, 161(2):692-701.
41. Hochmeister S., Zeitelhofer M., Bauer J., Nicolussi E.M., Fischer M.T., Heinke B., et al. After injection into the striatum, in vitro-differentiated microglia- and bone marrow-derived dendritic cells can leave the central nervous system via the blood stream. American Journal of Pathology 2008, 173(6):1669-1681.
42. Hatterer E., Touret M., Belin M.F., Honnorat J., Nataf S. Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions. PLoS One 2008, 3(10):e3321.
43. Walter B.A., Valera V.A., Takahashi S., Matsuno K., Ushiki T. Evidence of antibody production in the rat cervical lymph nodes after antigen administration into the cerebrospinal fluid. Archives of Histology and Cytology 2006, 69(1):37-47.
44. Baszler T.V., Long M.T., McElwain T.F., Mathison B.A. Interferon-gamma and interleukin-12 mediate protection to acute Neospora caninum infection in BALB/c mice. International Journal for Parasitology 1999, 29(10):1635-1646.
45. Klevar S., Kulberg S., Boysen P., Storset A.K., Moldal T., Bjorkman C., et al. Natural killer cells act as early responders in an experimental infection with Neospora caninum in calves. International Journal for Parasitology 2007, 37(3-4):329-339.
46. Ramamoorthy S., Sanakkayala N., Vemulapalli R., Duncan R.B., Lindsay D.S., Schurig G.S., et al. Prevention of lethal experimental infection of C57BL/6 mice by vaccination with Brucella abortus strain RB51 expressing Neospora caninum antigens. International Journal for Parasitology 2007, 37(13):1521-1529.
47. Ramamoorthy S., Sanakkayala N., Vemulapalli R., Jain N., Lindsay D.S., Schurig G.S., et al. Prevention of vertical transmission of Neospora caninum in C57BL/6 mice vaccinated with Brucella abortus strain RB51 expressing N. caninum protective antigens. International Journal for Parasitology 2007, 37(13):1531-1538.
48. Hemphill A., Vonlaufen N., Naguleswaran A. Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninum. Parasitology 2006, 133(Pt 3):261-278.