CpG-ODN combined with Neospora caninum lysate, but not with excreted-secreted antigen, enhances protection against infection in mice

Vaccine

Volumn 27, Issue 19, 2009, Pages 2570-2579

  Ribeiro, Dâmaso P ^a   Freitas, Marina M P ^a   Cardoso, Mariana R D ^a   Pajuaba, Ana C A M ^a   Silva, Neide M ^a   Mineo, Tiago W P ^a,b   Silva, João S ^b   Mineo, José R ^a   Silva, Deise A O ^a  

^a FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Adjuvant; CpG ODN; Neospora caninum; Vaccination

Indexed keywords

BACTERIAL ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CPG OLIGODEOXYNUCLEOTIDE 1826; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; NEOSPORA CANINUM EXCRETED SECRETED ANTIGEN; NEOSPORA CANINUM LYSATE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; MALE; MOUSE; NEOSPORA CANINUM; NEOSPOROSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TH1 CELL;

ANIMALS; ANTIBODIES, FUNGAL; ANTIGENS, FUNGAL; BODY WEIGHT; BRAIN; CELL PROLIFERATION; COCCIDIOSIS; CYTOKINES; FUNGAL VACCINES; IMMUNOGLOBULIN G; INJECTIONS, SUBCUTANEOUS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED C57BL; NEOSPORA; OLIGODEOXYRIBONUCLEOTIDES; SEVERITY OF ILLNESS INDEX; SPLEEN; SURVIVAL ANALYSIS; VACCINES, SUBUNIT;

EID: 63449138101     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.02.028     Document Type: Article

References (53)

1. Dubey J.P., Hattel A.L., Lindsay D.S., and Topper M.J. Neonatal Neospora caninum infection in dogs: isolation of the causative agent and the experimental transmission. J Am Vet Med Assoc 193 (1988) 1259-1263
2. Dubey J.P., Schares G., and Ortega-Mora L.M. Epidemiology and control of neosporosis and Neospora caninum. Clin Microbiol Rev 20 (2007) 323-367
3. Trees A.J., McAllister M.M., Guy C.S., McGarry J.W., Smith R.F., and Willians D.J.L. Neospora caninum oocyst challenge of pregnant cows. Vet Parasitol 109 (2002) 147-154
4. Willians D.J.L., and Trees A.J. Protecting babies: vaccine strategies to prevent foetal infection in Neospora caninum infected cattle. Parasite Immunol 28 (2006) 61-67
5. Willians D.J.L., Guy C.S., McGarry J.W., Guy F., Tasker L., Smith R.F., et al. Neospora caninum-associated abortion in cattle: the time of experimentally-induced parasitaemia during gestation determines foetal survival. Vet Parasitol 121 (2000) 347-358
6. Davison H.C., Otter A., and Trees A.J. Estimation of vertical and horizontal transmission parameters of Neospora caninum infections in dairy cattle. Int J Parasitol 29 (1999) 1683-1689
7. Hemphill A., Vonlaufen N., and Naguleswaran A. Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninum. Parasitol 133 (2006) 261-278
8. Baszler T.V., Long M.T., McElwain T.F., and Mathison B.A. Interferon-γ and interleukin-12 mediate protection to acute Neospora caninum infection in BALB/c mice. Int J Parasitol 29 (1999) 1635-1646
9. Epperon S., Bronnnimann K., Hemphill A., and Gottstein B. Susceptibility of B-cell deficient C57BL/6 (micro MT) mice to Neospora caninum infection. Parasite Immunol 21 (1999) 225-236
10. Akira S. Toll-like receptor signaling. J Biol Chem 278 (2003) 38105-38108
11. Debache K., Guionaud C., Alaeddine F., Mevissen M., and Hemphill A. Vaccination of mice with recombinant NcROP2 antigen reduces mortality and cerebral infection in mice infected with Neospora caninum tachyzoites. Int J Parasitol 38 (2008) 1455-1463
12. Lundén A., Wright S., Allen J.E., and Buxton D. Immunisation of mice against neosporosis. Int J Parasitol 32 (2002) 867-876
13. Ramamoorthy S., Lindsay D.S., Schurig G.G., Boyle S.M., Duncan R.B., Vemulapalli R., et al. Vaccination with γ-irradiated Neospora caninum tachyzoites protects mice against acute challenge with N. caninum. J Eurkaryot Microbiol 53 (2006) 151-156
14. Bartley P.M., Wright S., Chianini F., Buxton D., and Innes E.A. Inoculation of Balb/c mice with live attenuated tachyzoites protects against a lethal challenge of Neospora caninum. Parasitol 135 (2008) 13-21
15. Liddell S., Jenkins M., Collica C.M., and Dubey J.P. Prevention of vertical transfer Neospora caninum in BALB/c mice by vaccination. J Parasitol 85 (1999) 1072-1075
16. Nishikawa Y., Xuan X., Nagasawa H., Igarashi I., Fujisaki K., Otsuka H., et al. Prevention of vertical transmission of Neospora caninum in BALB/c mice by recombinant vaccinia virus carrying NcSRS2 gene. Vaccine 19 (2001) 1710-1716
17. Cannas A., Naguleswaran A., Muller N., Gottstein B., Eperon S., and Hemphill A. Vaccination of mice against experimental N.caninum infection using NcSAG-1 and NcSRS2-based recombinant antigens and DNA-vaccines. Parasitol 126 (2003) 303-312
18. Cannas A., Naguleswaran A., Muller N., Gottstein B., and Hemphill A. Reduced cerebral infection of Neospora caninum-infected mice after vaccination with recombinant microneme protein NcMIC3 and ribi adjuvant. J Parasitol 89 (2003) 44-50
19. Alaeddine F., Keller N., Leepin A., and Hemphill A. Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1. J Parasitol 91 (2005) 657-665
20. Srinivasan S., Muller J., Suana A., and Hemphill A. Vaccination with microneme protein NcMIC4 increases mortality in mice inoculated with Neospora caninum. J Parasitol 93 (2007) 1046-1055
21. Jenkins M., Parker C., Tuo W., Vinyard B., and Dubey J.P. Inclusion of CpG adjuvant with plasmid DNA coding for NcGRA7 improves protection against congenital neosporosis. Infect Immun 72 (2004) 1817-1819
22. Ramammoorthy S., Sanakkayala N., Vemulapalli R., Jain N., Lindsay D.S., and Schurig G.S. Prevention of vertical transmission of Neospora caninum in C57BL/6 mice vaccinated with Brucella abortus strain RB51 expressing N.caninum protective antigens. Int J Parasitol 37 (2007) 1531-1538
23. Cho J.H., Chung W.S., Song K.J., Na B.K., Kang S.W., Song C.Y., et al. Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against experimental Neospora caninum infection. Korean J Parasitol 43 (2005) 19-25
24. Ellis J., Miller C., Quinn H., Ryce C., and Reichel M.P. Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model). Vaccine 26 (2008) 5989-5996
25. Krieg A.M., and Vollmer J. Toll like receptors 7, 8, and 9: linking innate immunity to autoimmunity. Immunological Reviews 220 (2007) 251-269
26. Klinman D.M., Currie D., Gurse I., and Verthelyi D. Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol Rev 199 (2004) 201-216
27. Jaafari M.R., Badiee A., Khamesipour A., Samiei A., Soroush D., Kheiri M.T., et al. The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (grp63) encapsulated in cationic liposome. Vaccine 25 (2007) 6107-6117
28. El-Malky M., Shaohong L., Kumagai T., Yabu Y., Noureldin M.S., Saudy, et al. Protective effect of vaccination with Toxoplasma lysate antigen and CpG as an adjuvant against Toxoplasma gondii in susceptible C57BL/6 mice. Microbiol Immunol 49 (2005) 639-646
29. Mullen G.E.D., Aebig J.A., Dobrescu G., Rausch K., Lambert L., Long C.A., et al. Enhanced antibody production in mice to the malaria antigen AMA1 by CPG 7909 requires physical association of CpG and antigen. Vaccine 25 (2007) 5343-5347
30. Dubremetz J.F. Roptries are major players in Toxoplasma gondii invasion and host cell interaction. Cell Microbiol 9 (2007) 841-848
31. Lindsay D.S., Lenz S.D., Blagburn B.L., and Blake D.A. Characterization of temperature-sensitive strains of Neospora caninum in mice. J Parasitol 85 (1999) 64-67
32. Silva D.A.O., Lobato J., Mineo T.W., and Mineo J.R. Evaluation of serological tests for the diagnosis of Neospora caninum infection in dogs: optimization of cut off titers and inhibition studies of cross-reactivity with Toxoplasma gondii. Vet Parasitol 143 (2007) 234-244
33. Lowry O.H., Rosenborough N.J., Farr A.L., and Randall R.J. Protein measurement with folin phenol reagent. J Biol Chemisty 193 (1951) 265-275
34. Naguleswaran A., Cannas A., Keller N., Vonlaufen N., Schares G., Conraths F.J., et al. Neospora caninum microneme protein NcMIC3: secretion, subcellular localization, and functional involvement in host cell interaction. Infect Immun 69 (2001) 6483-6494
35. Matsuura T., and Kasper L.H. Molecular analysis and characterization of a protein involved in the replication of intracellular Toxoplasma gondii. Mol Biochem Parasitol 90 (1997) 403-413
36. Mineo J.R., Khan I.A., and Kasper L.H. Toxoplasma gondii: a monoclonal antibody that inhibits intracellular replication. Exp Parasitol 79 (1994) 351-361
37. Camargo M.E. Improved technique of indirect immunofluorescence for serological diagnosis of toxoplasmosis. Rev Inst Med Trop São Paulo 12 (1964) 117-118
38. Corral R.S., and Petray P.B. CpG DNA as a Th1-promoting adjuvant in immunization against Trypanossoma cruzi. Vaccine 19 (2000) 234-242
39. Bartley P.M., Wright S., Sales J., Chianini F., Buxton D., and Innes E.A. Long-term passage of tachyzoites in tissue culture can attenuate virulence of Neospora caninum in vivo. Parasitol 133 (2006) 421-432
40. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
41. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci 76 (1979) 4350-4356
42. Frank F.M., Petray P.B., Cazorla S.I., Munoz M.C., Corral R., and Malchiodi E.L. Use of a purified Trypanossoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with tripomastigotes. Vaccine 22 (2003) 77-86
43. Silva N.M., Tafuri W.L., Alvarez-Leite J.I., Mineo J.R., and Gazzinelli R.T. Toxoplasma gondii: in vivo expression of BAG-5 and cyst formation is independent of TNF p55 receptor and inducible nitric oxide synthase functions. Microb Infect 4 (2002) 261-270
44. Bernardes E.S., Silva N.M., Ruas L.P., Mineo J.R., Loyola A.M., Hsu D.K., et al. Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptative immunity. Am J Pathol 168 (2006) 1910-1920
45. Innes E.A. The host-parasite relationship in pregnant cattle infected with Neospora caninum. Parasitol 34 (2007) 1903-1910
46. Baszler T.V., McElwain T.F., and Mathison B.A. Immunization of BALB/c mice with killed Neospora caninum tachyzoite antigen induces a type 2 immune response and exacerbates encephalitis and neurological disease. Clin Diagn Lab Immunol 7 (2000) 893-898
47. Daryani A., Hosseini A.Z., and Dalimi A. Immune responses against excreted/secreted antigens of Toxoplasma gondii tachyzoites in the murine model. Vet Parasitol 113 (2003) 123-124
48. Hafid J., Vincent N., Flori P., Bellete B., Raberin H., and Sung R.T.M. Production of antibodies in murine mucosal immunization with Toxoplasma gondii excreted/secreted antigens. Vet Parasitol 128 (2005) 23-28
49. Holzmuller P., Cavaleyra M., Moreaux J., Kovacic R., Vincendeau P., Papierok G., et al. Lymphocytes of dogs immunised with purified excreted-secreted antigens of Leishmania infantum co-incubated with Leishmania infected macrophages produce IFN gamma resulting in nitric oxide-mediated amastigote apoptosis. Vet Immunol Immunopathol 106 (2005) 247-257
50. Chenik M., Lakhal S., Ben Khalef N., Zribi L., Louzir H., and Dellagi K. Approaches for the identification of potential excreted/secreted proteins of Leishmania major parasites. Parasitology 132 (2006) 493-509
51. Costa-Silva T.A., Meira C.S., Ferreira I.M., Himaroto R.M., and Pereira V.L.C. Evaluation of immunization with tachyzoite excreted-secreted proteins in a novel susceptible mouse model (AS/s) for Toxoplasma gondii. Exp Parasitol 120 (2008) 227-234
52. Zimmermann S., Dalpke A., and Heeg K. CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections. Int J Med Microbiol 298 (2007) 39-44
53. Spencer J.A., Smith B.F., Guarino A.J., Blagburn B.L., and Baker H.J. The use of CpG as an adjuvant to Toxopla gondii vaccination. Parasitol Rev 92 (2004) 313-316