Failure of a vaccine using immunogenic recombinant proteins rNcSAG4 and rNcGRA7 against neosporosis in mice

Vaccine

Volumn 27, Issue 52, 2009, Pages 7331-7338

  Aguado Martínez, Adriana ^a   Álvarez García, Gema ^a   Fernández García, Aurora ^a   Risco Castillo, Verónica ^a   Marugán Hernández, Virginia ^a   Ortega Mora, Luis M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Immune response; Mouse model; Neospora caninum; rNcGRA7; rNcSAG4; Vaccination

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GENOMIC DNA; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN RNCGRA7; RECOMBINANT PROTEIN RNCSAG4; RECOMBINANT PROTEIN RNCSAG4 PLUS PROTEIN RNCGRA7; RECOMBINANT VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BRADYZOITE; BRAIN INFECTION; CELLULAR IMMUNITY; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MIXTURE; DRUG SAFETY; FEMALE; FERTILITY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; LUNG INFECTION; MORTALITY; MOUSE; NEOSPORA CANINUM; NEOSPOROSIS; NEWBORN MORTALITY; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; VACCINATION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, PROTOZOAN; COCCIDIOSIS; DNA, PROTOZOAN; FEMALE; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; NEOSPORA; PREGNANCY; PROTOZOAN VACCINES; RECOMBINANT PROTEINS;

EID: 70649100321     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.09.050     Document Type: Article

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