A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs

ACS Chemical Biology

Volumn 9, Issue 4, 2014, Pages 913-921

  Lewallen, Daniel M ^a   Bicker, Kevin L ^a   Madoux, Franck ^b   Chase, Peter ^b   Anguish, Lynne ^a   Coonrod, Scott ^a   Hodder, Peter ^b   Thompson, Paul R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Department of Molecular Biology and Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOENZYME; CALCIUM ION; HOLOENZYME; HYDROLASE INHIBITOR; NSC 95397; PROTEIN ARGININE DEIMINASE; PROTEIN ARGININE DEIMINASE INHIBITOR; RUTHENIUM RED; SANGUINARINE; UNCLASSIFIED DRUG; CALCIUM; ENZYME INHIBITOR; HYDROLASE; PROTEIN BINDING; PROTEIN-ARGININE DEIMINASE;

ACTIVITY BASED PROTEIN PROFILING; ANALYTIC METHOD; ARTICLE; CALCIUM BINDING; CONFORMATIONAL TRANSITION; DRUG EFFICACY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; REPRODUCIBILITY; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOASSAY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; PRECLINICAL STUDY;

BINDING SITES; BIOLOGICAL ASSAY; CALCIUM; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HYDROLASES; MOLECULAR STRUCTURE; PROTEIN BINDING; RUTHENIUM RED;

EID: 84899078046     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400841k     Document Type: Article

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