Identification of macrophage extracellular trap-like structures in mammary gland adipose tissue: A preliminary study

Frontiers in Immunology

Volumn 4, Issue MAR, 2013, Pages

  Mohanan, Sunish ^a   Horibata, Sachi ^a   McElwee, John L ^a   Dannenberg, Andrew J ^b   Coonrod, Scott A ^a  

^a Department of Obstetrics Gynecology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

peptidylarginine deiminases, PAD2, ETosis, macrophage extracellular traps, adipose tissue inflammation, histone citrullination, deimination, crown like structures

Indexed keywords

HISTONE H4;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HISTOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MACROPHAGE MIGRATION; MAMMARY GLAND; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84883748457     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00067     Document Type: Article

References (27)

1. Amulic, B., and Hayes, G. (2011). Neutrophil extracellular traps. Curr. Biol. 21, R297-R298.
2. Aulik, N. A., Hellenbrand, K. M., and Czuprynski, C. J. (2012). Mannheimia haemolytica and its leukotoxin cause macrophage extracellular trap formation by bovine macrophages. Infect. Immun. 80, 1923-1933.
3. Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., et al. (2004). Neutrophil extracellular traps kill bacteria. Science 303, 1532-1535.
4. Cherrington, B. D., Morency, E., Struble, A. M., Coonrod, S. A., and Wakshlag, J. J. (2010). Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones. PLoS ONE 5:e11768. doi:10.1371/journal.pone.0011768
5. Cherrington, B. D., Zhang, X., McElwee, J. L., Morency, E., Anguish, L. J., and Coonrod, S. A. (2012). Potential role for PAD2 in gene regulation in breast cancer cells. PLoS ONE 7:e41242. doi:10.1371/journal.pone.0041242
6. Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., et al. (2005). Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46, 2347-2355.
7. Cleary, M. P., and Grossmann, M. E. (2009). Minireview: obesity and breast cancer: the estrogen connection. Endocrinology 150, 2537-2542.
8. Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., et al. (2007). Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 176, 231-241.
9. Gavet, O., and Pines, J. (2010). Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. Dev. Cell 18, 533-543.
10. Guimaraes-Costa, A. B., Nascimento, M. T., Wardini, A. B., Pinto-Da-Silva, L. H., and Saraiva, E. M. (2012). ETosis: a microbicidal mechanism beyond cell death. J. Parasitol. Res. 2012, 929743.
11. Hellenbrand, K. M., Forsythe, K. M., Rivera-Rivas, J. J., Czuprynski, C. J., and Aulik, N. A. (2013). Histophilus somni causes extracellular trap formation by bovine neutrophils and macrophages. Microb. Pathog. 54, 67-75.
12. Hong, J., Stubbins, R. E., Smith, R. R., Harvey, A. E., and Nunez, N. P. (2009). Differential susceptibility to obesity between male, female and ovariectomized female mice. Nutr. J. 8, 11.
13. Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., and Wang, Y. (2010). PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 207, 1853-1862.
14. Liu, C. L., Tangsombatvisit, S., Rosenberg, J. M., Mandelbaum, G., Gillespie, E. C., Gozani, O. P., et al. (2012). Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Arthritis Res. Ther. 14, R25.
15. Marcos, V., Zhou, Z., Yildirim, A. O., Bohla, A., Hector, A., Vitkov, L., et al. (2010). CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Nat. Med. 16, 1018-1023.
16. Mohanan, S., Cherrington, B. D., Horibata, S., McElwee, J. L., Thompson, P. R., and Coonrod, S. A. (2012). Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis. Biochem. Res. Int. doi:10.1155/2012/895343.
17. Morris, P. G., Hudis, C. A., Giri, D., Morrow, M., Falcone, D. J., Zhou, X. K., et al. (2011). Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev. Res. (Phila.) 4, 1021-1029.
18. Neeli, I., Khan, S. N., and Radic, M. (2008). Histone deimination as a response to inflammatory stimuli in neutrophils. J. Immunol. 180, 1895-1902.
19. Remijsen, Q., Vanden Berghe, T., Wirawan, E., Asselbergh, B., Parthoens, E., De Rycke, R., et al. (2011). Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res. 21, 290-304.
20. Saffarzadeh, M., Juenemann, C., Queisser, M. A., Lochnit, G., Barreto, G., Galuska, S. P., et al. (2012). Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS ONE 7:e32366. doi:10.1371/journal.pone.0032366
21. Subbaramaiah, K., Howe, L. R., Bhardwaj, P., Du, B., Gravaghi, C., Yantiss, R. K., et al. (2011). Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev. Res. (Phila.) 4, 329-346.
22. Subbaramaiah, K., Morris, P. G., Zhou, X. K., Morrow, M., Du, B., Giri, D., et al. (2012). Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2, 356-365.
23. Suganami, T., and Ogawa, Y. (2010). Adipose tissue macrophages: their role in adipose tissue remodeling. J. Leukoc. Biol. 88, 33-39.
24. Urban, C. F., Ermert, D., Schmid, M., Abu-Abed, U., Goosmann, C., Nacken, W., et al. (2009). Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog. 5:e1000639. doi:10.1371/journal.ppat.1000639
25. van Kruijsdijk, R. C., van der Wall, E., and Visseren, F. L. (2009). Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol. Biomarkers Prev. 18, 2569-2578.
26. Wang, Y., Li, M., Stadler, S., Correll, S., Li, P., Wang, D., et al. (2009). Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J. Cell Biol. 184, 205-213.
27. Zhang, X., Bolt, M., Guertin, M. J., Chen, W., Zhang, S., Cherrington, B. D., et al. (2012). Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor alpha target gene activation. Proc. Natl. Acad. Sci. U.S.A. 109, 13331-13336.