D-Amino acid-based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy

ACS Medicinal Chemistry Letters

Volumn 3, Issue 12, 2012, Pages 1081-1085

  Bicker, Kevin L ^a   Anguish, Lynne ^b   Chumanevich, Alexander A ^c   Cameron, Michael D ^a   Cui, Xiangli ^c   Witalison, Erin ^c   Subramanian, Venkataraman ^a   Zhang, Xuesen ^b   Chumanevich, Alena P ^c   Hofseth, Lorne J ^c   Coonrod, Scott A ^b   Thompson, Paul R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Cornell University ^*  (United States)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

D Amino acid; in cellulo efficacy; pharmacokinetic properties; protein arginine deiminases

Indexed keywords

AMIDINE; DEXTRO AMINO ACID; ISOENZYME; PROTEIN ARGININE DEIMINASE; PROTEIN ARGININE DEIMINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL KILLING; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOCHEMISTRY;

EID: 84871200341     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300288d     Document Type: Article

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