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Volumn 20, Issue 5, 2014, Pages 452-459

Angiotensin converting enzyme 2/Ang-(1-7)/mas axis protects brain from ischemic injury with a tendency of age-dependence

Author keywords

Aging; Angiotensin; Angiotensin converting enzyme 2; Ischemic stroke; NADPH oxidase

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; GLUCOSE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; 7-ALA-ANGIOTENSIN (1-7); ANGIOTENSIN I; ANGIOTENSIN I (1-7); ANGIOTENSIN II; CYBB PROTEIN, MOUSE; DIPEPTIDYL CARBOXYPEPTIDASE; MEMBRANE PROTEIN; NOX4 PROTEIN, MOUSE; PEPTIDE FRAGMENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 84899070073     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12233     Document Type: Article
Times cited : (51)

References (41)
  • 1
    • 0038606899 scopus 로고    scopus 로고
    • Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives
    • Veerasingham SJ, Raizada MK. Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br J Pharmacol 2003;139:191-202.
    • (2003) Br J Pharmacol , vol.139 , pp. 191-202
    • Veerasingham, S.J.1    Raizada, M.K.2
  • 2
    • 46449096453 scopus 로고    scopus 로고
    • Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress
    • Mayhan WG, Arrick DM, Sharpe GM, Sun H. Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress. Microcirculation 2008;15:225-236.
    • (2008) Microcirculation , vol.15 , pp. 225-236
    • Mayhan, W.G.1    Arrick, D.M.2    Sharpe, G.M.3    Sun, H.4
  • 3
    • 36248935988 scopus 로고    scopus 로고
    • Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain
    • Park L, Anrather J, Girouard H, Zhou P, Iadecola C. Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J Cereb Blood Flow Metab 2007;27:1908-1918.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1908-1918
    • Park, L.1    Anrather, J.2    Girouard, H.3    Zhou, P.4    Iadecola, C.5
  • 6
    • 33644861536 scopus 로고    scopus 로고
    • Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes
    • Gallagher PE, Chappell MC, Ferrario CM, Tallant EA. Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. Am J Physiol Cell Physiol 2006;290:C420-C426.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Gallagher, P.E.1    Chappell, M.C.2    Ferrario, C.M.3    Tallant, E.A.4
  • 7
    • 2642539225 scopus 로고    scopus 로고
    • Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
    • Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van GH. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004;203:631-637.
    • (2004) J Pathol , vol.203 , pp. 631-637
    • Hamming, I.1    Timens, W.2    Bulthuis, M.L.3    Lely, A.T.4    Navis, G.5    van, G.H.6
  • 8
    • 84876743592 scopus 로고    scopus 로고
    • ACE2-Ang-(1-7)-Mas axis in brain: a potential target for prevention and treatment of ischemic stroke
    • Jiang T, Gao L, Lu J, Zhang YD. ACE2-Ang-(1-7)-Mas axis in brain: a potential target for prevention and treatment of ischemic stroke. Curr Neuropharmacol 2013;11:209-217.
    • (2013) Curr Neuropharmacol , vol.11 , pp. 209-217
    • Jiang, T.1    Gao, L.2    Lu, J.3    Zhang, Y.D.4
  • 10
    • 34250815041 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature
    • Ishikawa M, Sekizuka E, Yamaguchi N, et al. Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature. Am J Physiol Heart Circ Physiol 2007;292:H2306-H2315.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Ishikawa, M.1    Sekizuka, E.2    Yamaguchi, N.3
  • 11
    • 80052853007 scopus 로고    scopus 로고
    • Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke
    • Mecca AP, Regenhardt RW, O'Connor TE, et al. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Exp Physiol 2011;96:1084-1096.
    • (2011) Exp Physiol , vol.96 , pp. 1084-1096
    • Mecca, A.P.1    Regenhardt, R.W.2    O'Connor, T.E.3
  • 12
    • 59849099636 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
    • Xia H, Feng Y, Obr TD, Hickman PJ, Lazartigues E. Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension 2009;53:210-216.
    • (2009) Hypertension , vol.53 , pp. 210-216
    • Xia, H.1    Feng, Y.2    Obr, T.D.3    Hickman, P.J.4    Lazartigues, E.5
  • 13
    • 76349095332 scopus 로고    scopus 로고
    • Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension
    • Feng Y, Xia H, Cai Y, et al. Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res 2010;106:373-382.
    • (2010) Circ Res , vol.106 , pp. 373-382
    • Feng, Y.1    Xia, H.2    Cai, Y.3
  • 14
    • 60549113487 scopus 로고    scopus 로고
    • Exaggeration of focal cerebral ischemia in transgenic mice carrying human renin and human angiotensinogen genes
    • Inaba S, Iwai M, Tomono Y, et al. Exaggeration of focal cerebral ischemia in transgenic mice carrying human renin and human angiotensinogen genes. Stroke 2009;40:597-603.
    • (2009) Stroke , vol.40 , pp. 597-603
    • Inaba, S.1    Iwai, M.2    Tomono, Y.3
  • 15
    • 70449659424 scopus 로고    scopus 로고
    • Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice
    • Chen S, Li G, Zhang W, et al. Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. Am J Physiol Regul Integr Comp Physiol 2009;297:R1526-R1531.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Chen, S.1    Li, G.2    Zhang, W.3
  • 16
    • 84870908340 scopus 로고    scopus 로고
    • Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging
    • Pena Silva RA, Chu Y, Miller JD, et al. Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke 2012;43:3358-3363.
    • (2012) Stroke , vol.43 , pp. 3358-3363
    • Pena Silva, R.A.1    Chu, Y.2    Miller, J.D.3
  • 17
    • 84864360749 scopus 로고    scopus 로고
    • Targeting NOX enzymes in the central nervous system: therapeutic opportunities
    • Sorce S, Krause KH, Jaquet V. Targeting NOX enzymes in the central nervous system: therapeutic opportunities. Cell Mol Life Sci 2012;69:2387-2407.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2387-2407
    • Sorce, S.1    Krause, K.H.2    Jaquet, V.3
  • 18
    • 79960810124 scopus 로고    scopus 로고
    • ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function
    • Xia H, Suda S, Bindom S, et al. ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS ONE 2011;6:e22682.
    • (2011) PLoS ONE , vol.6
    • Xia, H.1    Suda, S.2    Bindom, S.3
  • 19
    • 79959617416 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage
    • Chen J, Chen S, Chen Y, et al. Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage. Am J Physiol Endocrinol Metab 2011;301:E62-E71.
    • (2011) Am J Physiol Endocrinol Metab , vol.301
    • Chen, J.1    Chen, S.2    Chen, Y.3
  • 20
    • 34547802699 scopus 로고    scopus 로고
    • Superoxide (*O2-) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen
    • D'Agostino DP, Putnam RW, Dean JB. Superoxide (*O2-) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen. J Neurophysiol 2007;98:1030-1041.
    • (2007) J Neurophysiol , vol.98 , pp. 1030-1041
    • D'Agostino, D.P.1    Putnam, R.W.2    Dean, J.B.3
  • 21
    • 7944234144 scopus 로고    scopus 로고
    • Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia
    • Shichinohe H, Kuroda S, Yasuda H, et al. Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res 2004;1029:200-206.
    • (2004) Brain Res , vol.1029 , pp. 200-206
    • Shichinohe, H.1    Kuroda, S.2    Yasuda, H.3
  • 23
    • 84886089553 scopus 로고    scopus 로고
    • Brain ACE2 shedding contributes to the development of neurogenic hypertension
    • Xia H, Sriramula S, Chhabra KH, Lazartigues E. Brain ACE2 shedding contributes to the development of neurogenic hypertension. Circ Res 2013;113:1087-1096.
    • (2013) Circ Res , vol.113 , pp. 1087-1096
    • Xia, H.1    Sriramula, S.2    Chhabra, K.H.3    Lazartigues, E.4
  • 24
    • 57049183645 scopus 로고    scopus 로고
    • Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis
    • Lovren F, Pan Y, Quan A, et al. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol 2008;295:H1377-H1384.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Lovren, F.1    Pan, Y.2    Quan, A.3
  • 25
    • 77955440123 scopus 로고    scopus 로고
    • ACE2 and angiotensin 1-7 are increased in a human model of cardiovascular hyporeactivity: pathophysiological implications
    • Calo LA, Schiavo S, Davis PA, et al. ACE2 and angiotensin 1-7 are increased in a human model of cardiovascular hyporeactivity: pathophysiological implications. J Nephrol 2010;23:472-477.
    • (2010) J Nephrol , vol.23 , pp. 472-477
    • Calo, L.A.1    Schiavo, S.2    Davis, P.A.3
  • 27
    • 84868667825 scopus 로고    scopus 로고
    • Suppressing inflammation by inhibiting the NF-kappaB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia
    • Jiang T, Gao L, Guo J, Lu J, Wang Y, Zhang Y. Suppressing inflammation by inhibiting the NF-kappaB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia. Br J Pharmacol 2012;167:1520-1532.
    • (2012) Br J Pharmacol , vol.167 , pp. 1520-1532
    • Jiang, T.1    Gao, L.2    Guo, J.3    Lu, J.4    Wang, Y.5    Zhang, Y.6
  • 28
    • 77951183011 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2: a new target for neurogenic hypertension
    • Feng Y, Xia H, Santos RA, Speth R, Lazartigues E. Angiotensin-converting enzyme 2: a new target for neurogenic hypertension. Exp Physiol 2010;95:601-606.
    • (2010) Exp Physiol , vol.95 , pp. 601-606
    • Feng, Y.1    Xia, H.2    Santos, R.A.3    Speth, R.4    Lazartigues, E.5
  • 29
    • 77955175630 scopus 로고    scopus 로고
    • Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice
    • Tesanovic S, Vinh A, Gaspari TA, Casley D, Widdop RE. Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2010;30:1606-1613.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1606-1613
    • Tesanovic, S.1    Vinh, A.2    Gaspari, T.A.3    Casley, D.4    Widdop, R.E.5
  • 30
    • 48349091599 scopus 로고    scopus 로고
    • Markers of endothelial dysfunction in older subjects with late onsheimer's disease or vascular dementia
    • Zuliani G, Cavalieri M, Galvani M, et al. Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia. J Neurol Sci 2008;272:164-170.
    • (2008) J Neurol Sci , vol.272 , pp. 164-170
    • Zuliani, G.1    Cavalieri, M.2    Galvani, M.3
  • 31
    • 33644649803 scopus 로고    scopus 로고
    • Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
    • Girouard H, Iadecola C. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol 2006;100:328-335.
    • (2006) J Appl Physiol , vol.100 , pp. 328-335
    • Girouard, H.1    Iadecola, C.2
  • 32
  • 33
    • 84887041623 scopus 로고    scopus 로고
    • Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension
    • Toth P, Tucsek Z, Sosnowska D, et al. Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. J Cereb Blood Flow Metab 2013;33:1732-1742.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1732-1742
    • Toth, P.1    Tucsek, Z.2    Sosnowska, D.3
  • 34
    • 84884502543 scopus 로고    scopus 로고
    • Age-dependent exacerbation of white matter stroke outcomes: a role for oxidative damage and inflammatory mediators
    • Rosenzweig S, Carmichael ST. Age-dependent exacerbation of white matter stroke outcomes: a role for oxidative damage and inflammatory mediators. Stroke 2013;44:2579-2586.
    • (2013) Stroke , vol.44 , pp. 2579-2586
    • Rosenzweig, S.1    Carmichael, S.T.2
  • 35
    • 84884503312 scopus 로고    scopus 로고
    • Age-related decline in oligodendrogenesis retards white matter repair in mice
    • Miyamoto N, Pham LD, Hayakawa K, et al. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke 2013;44:2573-2578.
    • (2013) Stroke , vol.44 , pp. 2573-2578
    • Miyamoto, N.1    Pham, L.D.2    Hayakawa, K.3
  • 36
    • 84868282338 scopus 로고    scopus 로고
    • Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats
    • Bosnyak S, Widdop RE, Denton KM, Jones ES. Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats. Int J Hypertens 2012;2012:192567.
    • (2012) Int J Hypertens , vol.2012 , pp. 192567
    • Bosnyak, S.1    Widdop, R.E.2    Denton, K.M.3    Jones, E.S.4
  • 37
    • 73849117533 scopus 로고    scopus 로고
    • Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus
    • Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension 2010;55:166-171.
    • (2010) Hypertension , vol.55 , pp. 166-171
    • Gwathmey, T.M.1    Pendergrass, K.D.2    Reid, S.D.3    Rose, J.C.4    Diz, D.I.5    Chappell, M.C.6
  • 38
    • 56349133166 scopus 로고    scopus 로고
    • Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats
    • Zhang Y, Lu J, Shi J, et al. Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats. Neuropeptides 2008;42:593-600.
    • (2008) Neuropeptides , vol.42 , pp. 593-600
    • Zhang, Y.1    Lu, J.2    Shi, J.3
  • 39
    • 84885118956 scopus 로고    scopus 로고
    • Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species
    • Lee DY, Wauquier F, Eid AA, et al. Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species. J Biol Chem 2013;288:28668-28686.
    • (2013) J Biol Chem , vol.288 , pp. 28668-28686
    • Lee, D.Y.1    Wauquier, F.2    Eid, A.A.3
  • 41
    • 33751178591 scopus 로고    scopus 로고
    • Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite
    • Xu J, Xie Z, Reece R, Pimental D, Zou MH. Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite. Arterioscler Thromb Vasc Biol 2006;26:2688-2695.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2688-2695
    • Xu, J.1    Xie, Z.2    Reece, R.3    Pimental, D.4    Zou, M.H.5


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