Angiotensin-converting enzyme 2: A new target for neurogenic hypertension

Experimental Physiology

Volumn 95, Issue 5, 2010, Pages 601-606

  Feng, Yumei ^a   Xia, Huijing ^a   Santos, Robson A ^b   Speth, Robert ^c   Lazartigues, Eric ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE;

ANTIHYPERTENSIVE THERAPY; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE REGULATION; BLOOD VESSEL; BRAIN REGION; CARDIOVASCULAR FUNCTION; CONFERENCE PAPER; DRUG TARGETING; EXPERIMENTAL MODEL; GENE THERAPY; GENETIC MODEL; HEART; HEART FUNCTION; HUMAN; HYPERTENSION; KIDNEY; NONHUMAN; PATHOGENESIS; PRESSORECEPTOR REFLEX; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 77951183011     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2009.047407     Document Type: Conference Paper

References (27)

1. Bader M Ganten D (2008). Update on tissue renin-angiotensin systems. J Mol Med 86, 615 621.
2. Davisson RL (2003). Physiological genomic analysis of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 285, R498 R511.
3. Diez-Freire C, Vazquez J, Correa de Adjounian MF, Ferrari MFR, Yuan L, Silver X, Torres R Raizada MK (2006). ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR. Physiol Genomics 27, 12 19.
4. 4 receptors. J Hypertens 26, 2008 2015.
5. Feng Y, Yue X, Xia H, Bindom SM, Hickman PJ, Filipeanu CM, Wu G Lazartigues E (2008). Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Res 102, 729 736.
6. Goldstein DS (1983). Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5, 86 99.
7. Grassi G Mancia G (2004). Neurogenic hypertension: is the enigma of its origin near the solution? Hypertension 43, 154 155.
8. Johnson AK Thunhorst RL (1997). The neuroendocrinology of thirst and salt appetite: visceral sensory signals and mechanisms of central integration. Front Neuroendocrinol 18, 292 353.
9. Julius S Majahalme S (2000). The changing face of sympathetic overactivity in hypertension. Ann Med 32, 365 370.
10. Lavoie JL Sigmund CD (2003). Minireview: overview of the renin-angiotensin system - an endocrine and paracrine system. Endocrinology 144, 2179 2183.
11. Lazartigues E, Feng Y Lavoie JL (2007). The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. Curr Pharm Des 13, 1231 1245.
12. Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE Sigmund CD (1996). Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest 97, 1047 1055.
13. Nagata S, Kato J, Sasaki K, Minamino N, Eto T Kitamura K (2006). Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system. Biochem Biophys Res Commun 350, 1026 1031.
14. Paul M, Poyan Mehr A Kreutz R (2006). Physiology of local renin-angiotensin systems. Physiol Rev 86, 747 803.
15. Rentzsch B, Iliescu R, Todiras M, Popova E, Baltatu O, Santos R Bader M (2007). Transgenic ACE2 overexpression in vascular smooth muscle of SHR-SP rats reduces blood pressure and improves endothelial function. Hypertension 50, e89.
16. Sakai K, Hirooka Y, Shigematsu H, Kishi T, Ito K, Shimokawa H, Takeshita A Sunagawa K (2005). Overexpression of eNOS in brain stem reduces enhanced sympathetic drive in mice with myocardial infarction. Am J Physiol Heart Circ Physiol 289, H2159 H2166.
17. Sakima A, Averill DB, Gallagher PE, Kasper SO, Tommasi EN, Ferrario CM Diz DI (2005). Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii. Hypertension 46, 333 340.
18. Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL Touyz RM (2007). Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49, 185 192.
19. Schiavone MT, Santos RAS, Brosnihan KB, Khosla MC Ferrario CM (1988). Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide. Proc Natl Acad Sci U S A 85, 4095 4098.
20. 2 receptor-mediated hypotension. J Hum Hypertens 14 (Suppl 1 S40 S46.
21. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G Turner AJ (2000). A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 275 33238 33243.
22. Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A Tummino P (2002). Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 277, 14838 14843.
23. Xia H, Feng Y, Obr TD, Hickman PJ Lazartigues E (2009). Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension 53, 210 216.
24. Xu P, Costa-Goncalves AC, Todiras M, Rabelo LA, Sampaio WO, Moura MM, Santos SS, Luft FC, Bader M, Gross V, Alenina N Santos RAS (2008). Endothelial dysfunction and elevated blood pressure in Mas gene-deleted mice. Hypertension 51, 574 580.
25. Yamazato M, Yamazato Y, Sun C, Diez-Freire C Raizada MK (2007). Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 49, 926 931.
26. Yang R, Smolders I, De Bundel D, Fouyn R, Halberg M, Demaegdt H, Vanderheyden P Dupont AG (2008). Brain and peripheral angiotensin II type 1 receptors mediate renal vasoconstrictor and blood pressure responses to angiotensin IV in the rat. J Hypertens 26, 998 1007.
27. Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, Spitz DR Davisson RL (2002). Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res 91, 1038 1045.