APC/C is an essential regulator of centrosome clustering

Nature Communications

Volumn 5, Issue , 2014, Pages

  Drosopoulos, Konstantinos ^a   Tang, Chan ^a,b   Chao, William C H ^a,c   Linardopoulos, Spiros ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b CRUCELL HOLLAND BV   (Netherlands)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX SUBUNIT 3; APC PROTEIN; CELL CYCLE PROTEIN 20; DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN 5; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UVOMORULIN; KIF11 PROTEIN, HUMAN; KINESIN; MONASTROL; PYRIMIDINE DERIVATIVE; THIOKETONE;

BIOASSAY; CANCER; CELL ORGANELLE; CLUSTER ANALYSIS; GENETIC ANALYSIS; INHIBITOR; NUMERICAL MODEL; PROTEIN;

ARTICLE; CELL CYCLE S PHASE; CENTROSOME; CYTOKINESIS; DIPLOIDY; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; METAPHASE; MITOSIS; PHENOTYPE; PROPHASE; PROTEIN DEGRADATION; PROTEIN STABILITY; UBIQUITINATION; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMALS; CENTROSOME; GENES, APC; HUMANS; KINESIN; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROTEIN STABILITY; PYRIMIDINES; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, AMINO ACID; THIONES;

EID: 84899064804     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4686     Document Type: Article

References (42)

1. Nigg, E. A. Centrosome duplication: of rules and licenses. Trends Cell Biol. 17, 215-221 (2007). (Pubitemid 46679244)
2. Quintyne, N. J., Reing, J. E., Hoffelder, D. R., Gollin, S. M. & Saunders, W. S. Spindle multipolarity is prevented by centrosomal clustering. Science 307, 127-129 (2005). (Pubitemid 40093495)
3. Ganem, N. J., Godinho, S. A. & Pellman, D. A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282 (2009).
4. Kwon, M. et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 22, 2189-2203 (2008).
5. Tanenbaum, M. E., Macurek, L., Galjart, N. & Medema, R. H. Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J. 27, 3235-3245 (2008).
6. Leber, B. et al. Proteins required for centrosome clustering in cancer cells. Sci. Transl. Med. 2, 33ra38 (2010).
7. Pines, J. Cubism and the cell cycle: the many faces of the APC/C. Nat. Rev. Mol. Cell Biol. 12, 427-438 (2011).
8. Peters, J. M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol. 7, 644-656 (2006).
9. Musacchio, A. & Salmon, E. D. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8, 379-393 (2007). (Pubitemid 46643240)
10. Szklarczyk, D. et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39, D561-D568 (2011).
11. Zeng, X. et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer cell 18, 382-395 (2010).
12. Zeng, X. & King, R. W. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat. Chem. Biol. 8, 383-392 (2012).
13. Rebacz, B. et al. Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen. Cancer Res. 67, 6342-6350 (2007). (Pubitemid 47037517)
14. Kapitein, L. C. et al. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435, 114-118 (2005). (Pubitemid 40655918)
15. Ferenz, N. P., Paul, R., Fagerstrom, C., Mogilner, A. & Wadsworth, P. Dynein antagonizes eg5 by crosslinking and sliding antiparallel microtubules. Curr. Biol 19, 1833-1838 (2009).
16. Heck, M. M. et al. The kinesin-like protein KLP61F is essential for mitosis in Drosophila. J. Cell Biol. 123, 665-679 (1993). (Pubitemid 23324923)
17. Kashina, A. S., Scholey, J. M., Leszyk, J. D. & Saxton, W. M. An essential bipolar mitotic motor. Nature 384, 225 (1996). (Pubitemid 26396963)
18. Ma, N., Titus, J., Gable, A., Ross, J. L. & Wadsworth, P. TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle. J. Cell Biol. 195, 87-98 (2011).
19. Pfleger, C. M. & Kirschner, M. W. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14, 655-665 (2000). (Pubitemid 30176820)
20. Glotzer, M., Murray, A. W. & Kirschner, M. W. Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138 (1991). (Pubitemid 21912025)
21. Chao, W. C., Kulkarni, K., Zhang, Z., Kong, E. H. & Barford, D. Structure of the mitotic checkpoint complex. Nature 484, 208-213 (2012).
22. Taguchi, S. et al. Degradation of human Aurora-A protein kinase is mediated by hCdh1. FEBS Lett. 519, 59-65 (2002). (Pubitemid 34521992)
23. Sedgwick, G. G. et al. Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. EMBO J. 32, 303-314 (2013).
24. He, J. et al. Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol. Cell. 50, 649-660 (2013).
25. Ostapenko, D., Burton, J. L. & Solomon, M. J. Identification of anaphase promoting complex substrates in S. cerevisiae. PloS ONE 7, e45895 (2012).
26. Crasta, K., Lim, H. H., Giddings, Jr T. H., Winey, M. & Surana, U. Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle. Nat. Cell Biol. 10, 665-675 (2008). (Pubitemid 351772932)
27. Mitchison, T. & Kirschner, M. Dynamic instability of microtubule growth. Nature 312, 237-242 (1984). (Pubitemid 15201998)
28. Goshima, G. & Scholey, J. M. Control of mitotic spindle length. Annu. Rev. Cell Dev. Biol. 26, 21-57 (2010).
29. Dumont, S. & Mitchison, T. J. Force and length in the mitotic spindle. Curr. Biol. 19, R749-R761 (2009).
30. Shimamoto, Y., Maeda, Y. T., Ishiwata, S., Libchaber, A. J. & Kapoor, T. M. Insights into the micromechanical properties of the metaphase spindle. Cell 145, 1062-1074 (2011).
31. van den Wildenberg, S. M. et al. The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations. Curr. Biol. 18, 1860-1864 (2008).
32. Wollman, R., Civelekoglu-Scholey, G., Scholey, J. M. & Mogilner, A. Reverse engineering of force integration during mitosis in the Drosophila embryo. Mol. Syst. Biol. 4, 195 (2008).
33. Mimori-Kiyosue, Y. & Tsukita, S. 'Search-and-capture' of microtubules through plus-end-binding proteins (+TIPs). J. Biochem. 134, 321-326 (2003). (Pubitemid 37288329)
34. Kalinina, I. et al. Pivoting of microtubules around the spindle pole accelerates kinetochore capture. Nat. Cell Biol. 15, 82-87 (2013).
35. Cai, S., O'Connell, C. B., Khodjakov, A. & Walczak, C. E. Chromosome congression in the absence of kinetochore fibres. Nat. Cell Biol. 11, 832-838 (2009).
36. Gaitanos, T. N. et al. Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J. 28, 1442-1452 (2009).
37. Manchado, E. et al. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55alpha, delta phosphatase. Cancer Cell 18, 641-654 (2010).
38. Bassermann, F. et al. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 134, 256-267 (2008). (Pubitemid 352010329)
39. Sigl, R. et al. Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J. Cell Sci. 122, 4208-4217 (2009).
40. Eguren, M. et al. The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun. 4, 2880 (2013).
41. Naoe, H. et al. The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol. Cell Biol. 30, 3994-4005 (2010).
42. Drosopoulos, K. & Linardopoulos, S. Integration of RNAi and small molecule screens to identify targets for drug development. Methods Mol. Biol. 986, 97-104 (2013).