Identification of Anaphase Promoting Complex Substrates in S. cerevisiae

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Ostapenko, Denis ^a   Burton, Janet L ^a   Solomon, Mark J ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; BINDING PROTEIN; MESSENGER RNA; PROTEIN; PROTEIN KINASE; PROTEIN KINASE MPS1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDR3; TRANSCRIPTION FACTOR TOS4; UNCLASSIFIED DRUG; UVOMORULIN; YBR138C PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; M PHASE CELL CYCLE CHECKPOINT; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INSTABILITY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA PROCESSING; SACCHAROMYCES CEREVISIAE; TWO HYBRID SYSTEM; YEAST;

CELL CYCLE; CELL PROLIFERATION; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; MODELS, BIOLOGICAL; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

SACCHAROMYCETALES;

EID: 84866859467     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045895     Document Type: Article

References (54)

1. Kerscher O, Felberbaum R, Hochstrasser M, (2006) Modification of proteins by ubiquitin and ubiquitin-like proteins. Ann Rev Cell Dev Biol 22: 159-180.
2. Peters JM, (2006) The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 7: 644-656.
3. Petroski MD, Deshaies RJ, (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6: 9-20.
4. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, et al. (2006) An architectural map of the anaphase-promoting complex. Genes & Dev 20: 449-460.
5. Burton JL, Solomon MJ, (2001) D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes & Dev 15: 2381-2395.
6. Glotzer M, Murray AW, Kirschner MW, (1991) Cyclin is degraded by the ubiquitin pathway. Nature 349: 132-138.
7. Pfleger CM, Kirschner MW, (2000) The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes & Dev 14: 655-665.
8. Fang G, Yu H, Kirschner MW, (1998) The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & Dev 12: 1871-1883.
9. Hwang LH, Lau LF, Smith DL, Mistrot CA, Hardwick KG, et al. (1998) Budding yeast Cdc20: a target of the spindle checkpoint. Science 279: 1041-1044.
10. Yu H, (2002) Regulation of APC-Cdc20 by the spindle checkpoint. Curr Opin Cell Biol 14: 706-714.
11. Enquist-Newman M, Sullivan M, Morgan DO, (2008) Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell 30: 437-446.
12. Jaspersen SL, Charles JF, Morgan DO, (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol 9: 227-236.
13. Kimata Y, Trickey M, Izawa D, Gannon J, Yamamoto M, et al. (2008) A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Dev Cell 14: 446-454.
14. Ostapenko D, Burton JL, Wang R, Solomon MJ, (2008) Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol 28: 4653-4664.
15. Zachariae W, Schwab M, Nasmyth K, Seufert W, (1998) Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 282: 1721-1724.
16. Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, et al. (2003) Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell 113: 101-113.
17. Klitzing C, Huss R, Illert AL, Froschl A, Wotzel S, et al. (2011) APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1. PLoS One 6: e28998.
18. Shirayama M, Toth A, Galova M, Nasmyth K, (1999) APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 402: 203-207.
19. Thornton BR, Toczyski DP, (2003) Securin and B-cyclin/CDK are the only essential targets of the APC. Nat Cell Biol 5: 1090-1094.
20. Hardwick KG, Weiss E, Luca FC, Winey M, Murray AW, (1996) Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 273: 953-956.
21. Weiss E, Winey M, (1996) The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J Cell Biol 132: 111-123.
22. Schwab M, Lutum AS, Seufert W, (1997) Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90: 683-693.
23. Hildebrandt ER, Hoyt MA, (2001) Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence. Mol Biol Cell 12: 3402-3416.
24. Juang YL, Huang J, Peters JM, McLaughlin ME, Tai CY, et al. (1997) APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 275: 1311-1314.
25. Shirayama M, Zachariae W, Ciosk R, Nasmyth K, (1998) The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J 17: 1336-1349.
26. Woodbury EL, Morgan DO, (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol 9: 106-112.
27. Ostapenko D, Solomon MJ, (2011) Anaphase promoting complex-dependent degradation of transcriptional repressors Nrm1 and Yhp1 in Saccharomyces cerevisiae. Mol Biol Cell 22: 2175-2184.
28. Rothstein R, (1991) Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol 194: 281-301.
29. Burton JL, Solomon MJ, (2000) Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex. Mol Cell Biol 20: 4614-4625.
30. D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, et al. (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19: 223-234.
31. James P, Halladay J, Craig EA, (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436.
32. Goldstein AL, McCusker JH, (1999) Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast 15: 1541-1553.
33. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, et al. (2003) Global analysis of protein expression in yeast. Nature 425: 737-741.
34. Gietz RD, Sugino A, (1988) New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74: 527-534.
35. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, et al. (1995) Current Protocols in Molecular Biology. New York: John Wiley & Sons.
36. Solomon MJ, Lee T, Kirschner MW, (1992) Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol Biol Cell 3: 13-27.
37. Burton JL, Xiong Y, Solomon MJ, (2011) Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1. EMBO J 30: 1818-1829.
38. Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, et al. (2007) Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and Its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell 18: 5139-5153.
39. Belle A, Tanay A, Bitincka L, Shamir R, O'Shea EK, (2006) Quantification of protein half-lives in the budding yeast proteome. Proc Natl Acad Sci U S A 103: 13004-13009.
40. Palframan WJ, Meehl JB, Jaspersen SL, Winey M, Murray AW, (2006) Anaphase inactivation of the spindle checkpoint. Science 313: 680-684.
41. Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM, (2005) The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. Mol Cell 18: 543-553.
42. Horak CE, Luscombe NM, Qian J, Bertone P, Piccirrillo S, et al. (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes & Dev 16: 3017-3033.
43. Zhu Y, Xiao W, (2004) Pdr3 is required for DNA damage induction of MAG1 and DDI1 via a bi-directional promoter element. Nucleic Acids Res 32: 5066-5075.
44. Sopko R, Huang D, Preston N, Chua G, Papp B, et al. (2006) Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 21: 319-330.
45. Kucharczyk R, Gromadka R, Migdalski A, Slonimski PP, Rytka J, (1999) Disruption of six novel yeast genes located on chromosome II reveals one gene essential for vegetative growth and two required for sporulation and conferring hypersensitivity to various chemicals. Yeast 15: 987-1000.
46. Hershkovits G, Bangio H, Cohen R, Katcoff DJ, (2006) Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p. Proc Natl Acad Sci U S A 103: 9808-9813.
47. Mangus DA, Smith MM, McSweeney JM, Jacobson A, (2004) Identification of factors regulating poly(A) tail synthesis and maturation. Mol Cell Biol 24: 4196-4206.
48. Hannich JT, Lewis A, Kroetz MB, Li SJ, Heide H, et al. (2005) Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem 280: 4102-4110.
49. Uzunova K, Gottsche K, Miteva M, Weisshaar SR, Glanemann C, et al. (2007) Ubiquitin-dependent proteolytic control of SUMO conjugates. J Biol Chem 282: 34167-34175.
50. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP, (2009) Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell 33: 581-590.
51. Liu C, van Dyk D, Choe V, Yan J, Majumder S, et al. (2011) Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase. J Biol Chem 286: 43660-43667.
52. Bastos de Oliveira FM, Harris MR, Brazauskas P, de Bruin RA, Smolka MB, (2012) Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes. EMBO J 31: 1798-1810.
53. Ahlskog JK, Bjork JK, Elsing AN, Aspelin C, Kallio M, et al. (2010) Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Mol Cell Biol 30: 5608-5620.
54. Zhang L, Park CH, Wu J, Kim H, Liu W, et al. (2010) Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. EMBO J 29: 1726-1737.