Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides

ACS Chemical Biology

Volumn 9, Issue 4, 2014, Pages 904-912

  Tran, Tuan ^a,b   Childs Disney, Jessica L ^a   Liu, Biao ^a,c   Guan, Lirui ^a   Rzuczek, Suzanne ^a   Disney, Matthew D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID; RNA; MOLECULAR LIBRARY; PROTEIN BINDING;

ARTICLE; ATAXIA; BINDING AFFINITY; CONTROLLED STUDY; FRAGILE X ASSOCIATED TREMOR ATAXIA SYNDROME; FRAGILE X MENTAL RETARDATION 1 GENE; FRAGILE X SYNDROME; GENE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR RECOGNITION; OPEN READING FRAME; PRIORITY JOURNAL; RNA STRUCTURE; RNA TRANSLATION; SPLICING DEFECT; TREMOR; TRINUCLEOTIDE REPEAT; ANIMAL; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IC50; MOLECULAR LIBRARY; PHARMACOLOGY; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ATAXIA; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COS CELLS; DRUG DELIVERY SYSTEMS; FRAGILE X SYNDROME; GENE EXPRESSION REGULATION; INHIBITORY CONCENTRATION 50; OLIGONUCLEOTIDES; POLYMERASE CHAIN REACTION; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; TREMOR; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84899061694     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400875u     Document Type: Article

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