Controversies in the cellular pharmacology of oligodeoxynucleotides

CIBA Foundation Symposia

Volumn , Issue 209, 1997, Pages 79-93

  Stein, C A ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GUANOSINE;

ABSORPTION; ANIMAL; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CHEMISTRY; HUMAN; METABOLISM; NEUTROPHIL; REVIEW;

ABSORPTION; ANIMALS; CELL COMPARTMENTATION; CELL MEMBRANE; GUANOSINE; HUMANS; NEUTROPHILS; OLIGONUCLEOTIDES, ANTISENSE;

EID: 0031304970     PISSN: 03005208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (31)

1. Aguilar L, Hemar A, Dautry-Varsat A, Blumenfeld M 1996 Hairpin, dumbbell, and single-stranded phosphodiester oligonucleotides exhibit identical uptake in T lymphocyte cell lines. Antisense Nucleic Acid Drug Dev 6:157-163
2. Beltinger C, Saragovi HU, Smith RM et al 1995 Binding, uptake and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides. J Clin Invest 95:1814-1823
3. Benimetskaya L, Loike J, Khaled Z, Wright S, Kai T, Stein CA 1997 Mac-1 (CD11b/CD18) is an oligodeoyxnucleotide binding protein. Nat Med 3:414-420
4. Bergan R, Connell Y, Fahmy B, Neckers L 1993 Electroporation enhances c-myc antisense oligodeoxynucleotide efficacy. Nucleic Acids Res 21:3567-3573
5. Bit R, Davis D, Elliot L et al 1993 Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction. J Med Chem 36:21-29
6. Fenster SD, Wagner R, Froehler BC, Chin DJ 1994 Inhibition of human immunodeficiency virus type-1 env expression by C-5 propyne oligonucleotides specific for rev response element stem loop V. Biochemistry 33:8391-8398
7. Gasparro FP, Dall'Amico R, O'Malley M, Heald PW, Elelson R 1990 Cell membrane DNA: a new target for psoralen photoadduct formation. Photochem Photobiol 52:315-321
8. Geselowitz DA, Neckers LM 1992 Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radiolabeled crosslinker. Antisense Res Dev 2:17-26
9. Giles RV, Spiller DG, Tidd DM 1995 Detection of ribonuclease H-generated mRNA fragments in human leukemia cells following reversible membrane permeabilization in the presence of antisense oligodeoxynucleotides. Antisense Res Dev 5:23-31
10. Goodarzi G, Watabe M, Watabe K 1991 Binding of oligonucleotides to cell membranes at acidic pH. Biochem Biophys Res Commun 181:1343-1351
11. Hawley P, Gibson I 1996 Interaction of oligodeoxynucleotides with mammalian cells. Antisense Nucleic Acid Drug Dev 6:197-206
12. Khaled Z, Rideout D, O'Driscoll KR et al 1995 Effects of suramin-related and other clinically-therapeutic polyanions on protein kinase C activity. Clin Cancer Res 1:113-122
13. Krieg A, Gmelig-Meyling F, Courley M, Kisch W, Chrisey L, Steinberg AD 1991 Uptake of oligodeoxyribonucleotides by lymphoid cells is heterogeneous and inducible. Antisense Res Dev 1:161-171
14. Krieg AM, Tonkinson J, Maison S et al 1993 Modification of antisense phosphodiester oligodeoxynucucleotides by a 5′-cholesteryl moiety increases cellular association and improves efficacy. Proc Natl Acad Sci USA 90:1048-1052
15. Liu JP 1996 Protein kinase C and its substrates. Mol Cell Endocrinol 116:1-29
16. Loke SL, Stein C, Zhang X et al 1989 Characterization of oligodeoxynucleotide transport into living cells. Proc Natl Acad Sci USA 86:3474-3478
17. Martiny-Baron G, Kazanietz M, Mischak H et al 1993 Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268:9194-9197
18. Nelson N 1991 Structure and pharmacology of the proton ATPases. Trends Pharmacol Sci 12:71-75
19. Rappaport J, Hanss B, Kopp JB et al 1995 Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy. Kidney Int 47:1462-1469
20. Spiller DG, Tidd DM 1995 Nuclear delivery of antisense oligodeoxynucleotides through reversible permeabilization of human leukemia cells with streptolysin O. Antisense Res Dev 5:13-22
21. Stein CA, Neckers LM, Nair BC, Mumbauer S, Hoke G, Pal R 1991 Phosphorothioate oligodeoxynucleotide interferes with binding of HIV-1 gp120 to CD4. J Acquired Immune Defic Syndr Res 4:686-693
22. Stein CA, Tonkinson JL, Zhang L-M et al 1993 Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells. Biochemistry 32:4855-4861
23. Tonkinson JL, Stein CA 1994 Patterns of intracellular compartmentalization, trafficking and acidification of 5′-fluorescein labeled phosphodiester and phosphorothioate oligodeoxynucleotides in HL60 cells. Nucleic Acids Res 22:4268-4275
24. Tonkinson, JL, Guvakova M, Khaled Z et al 1994 Cellular pharmacology and protein binding of phosphoromonothioate and phosphorodithioate oligodeoxynucleotides: a comparative study. Antisense Res Dev 4:269-278
25. Vlassov VV, Balakireva LA, Yakubov LA 1994 Transport of oligonucleotides across natural and model membranes. Biochim Biophys Acta 1197:95-108
26. Wu-Pong S, Weiss T, Hunt CA 1994 Calcium dependent cellular uptake of a c-myc antisense oligonucleotide. Cell Mol Biol 40:843-850
27. Yakubov LA, Deeva EA, Zarytova VF et al 1989 Mechanism of oligonucleotide uptake by cells: involvement of specific receptors? Proc Natl Acad Sci USA 86:6454-6458
28. Yakubov LA, Khaled Z, Zhang L-M, Truneh A, Vlassov V, Stein CA 1993 Oligodeoxynucleotides interact with recombinant CD4 at multiple sites. J Biol Chem 268:18818-18823
29. Yao GQ, Corrias S, Cheng YC 1996 Identification of two oligodeoxyribonucleotide-binding proteins on plasma membranes of human cell lines. Biochem Pharmacol 51:431-436
30. +-ATPases, inhibits acidification and protein degradation in lysosomes of cultured cells. J Biol Chem 266:17707-17712
31. Zabner J, Fasbender A, Moninger T, Poellinger K, Welsh M 1995 Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem 270:18997-19007