Auristatin antibody drug conjugate physical instability and the role of drug payload

Bioconjugate Chemistry

Volumn 25, Issue 4, 2014, Pages 656-664

  Adem, Yilma T ^a   Schwarz, Kelly A ^a   Duenas, Eileen ^a   Patapoff, Thomas W ^a   Galush, William J ^a   Esue, Osigwe ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFERENTIAL SCANNING CALORIMETRY; IONIC STRENGTH; STABILITY;

ANTIBODY-DRUG CONJUGATES; CONJUGATION PROCESS; CYTOTOXIC AGENTS; DRUG LOAD; HIGH IONIC STRENGTH; HYDROPHOBICS; LOAD DISTRIBUTIONS; LOW IONIC STRENGTH; PHYSICAL STABILITY; SULFHYDRYL GROUPS;

MONOCLONAL ANTIBODIES;

MONOCLONAL ANTIBODY; THIOL GROUP; VEDOTIN; ANTIBODY CONJUGATE; OLIGOPEPTIDE;

ARTICLE; CAPILLARY ISOELECTRIC FOCUSING; CHEMICAL ANALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; GEL PERMEATION CHROMATOGRAPHY; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IONIC STRENGTH; MELTING POINT; MOLECULAR WEIGHT; THERMOSTABILITY; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG STABILITY; HUMAN; OSMOLARITY; TIME;

ANIMALS; ANTIBODIES, MONOCLONAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHO CELLS; CRICETULUS; DRUG STABILITY; HUMANS; IMMUNOCONJUGATES; OLIGOPEPTIDES; OSMOLAR CONCENTRATION; TIME FACTORS;

EID: 84899030660     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400439x     Document Type: Article

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