Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: Inhibition of aggregation by methoxytriethyleneglycol chains

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4336-4343

  King, H Dalton ^a   Dubowchik, Gene M ^a   Mastalerz, Harold ^a   Willner, David ^a   Hofstead, Sandra J ^a   Firestone, Raymond A ^a,b   Lasch, Shirley J ^c,d   Trail, Pamela A ^c,d  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c Bayer Research Center ^*

^d BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; DIMER; DOXORUBICIN; HYDRAZONE DERIVATIVE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BR96; PEPTIDE; TRIETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ARTICLE; CHEMICAL BOND; CONJUGATE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR INTERACTION; PH;

EID: 0037068501     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020149g     Document Type: Article

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