Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: Inhibition of aggregation by methoxytriethyleneglycol chains

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4336-4343

  King, H Dalton ^a   Dubowchik, Gene M ^a   Mastalerz, Harold ^a   Willner, David ^a   Hofstead, Sandra J ^a   Firestone, Raymond A ^a,b   Lasch, Shirley J ^c,d   Trail, Pamela A ^c,d  

^a BRISTOL MYERS SQUIBB   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c Bayer Research Center ^*

^d BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; DIMER; DOXORUBICIN; HYDRAZONE DERIVATIVE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BR96; PEPTIDE; TRIETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ARTICLE; CHEMICAL BOND; CONJUGATE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR INTERACTION; PH;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; DIMERIZATION; DIPEPTIDES; DOXORUBICIN; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMMUNOCONJUGATES; INHIBITORY CONCENTRATION 50; TUMOR CELLS, CULTURED;

EID: 0037068501     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020149g     Document Type: Article

References (15)

1. y-related cell surface antigen
2. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates
3. Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates
4. (6-Maleimidocaproyl)hydrazone of doxorubicin - A new derivative for the preparation of immunoconjugates of doxorubicin
5. Cathepsin B-labile dipeptide linkers for antigen-specific lysosomal release of doxorubicin from internalizing immunoconjugates: Model studies of enzymatic drug release and in vitro anticancer activity
6. Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages
7. The specificity of uptake of model immune complexes and other protein aggregates by the murine reticuloendothelial system
8. Novel acid labile COL1 trityl-linked difluoronucleoside immunoconjugates: Synthesis, characterization, and biological activity
9. Introduction to chemistry and biological applications of poly(ethylene glycol)
10. The conformation of polymers at interfaces
11. Antigen specific activity of carcinoma reactive BR64-Adriamycin conjugates evaluated in vitro and in human tumor xenograft models